National Toxicology Program

National Toxicology Program

OHAT Evaluation Process

The NTP Office of Health Assessment and Translation develops literature-based evaluations to reach conclusions about potential human health hazards and to examine the state of the science. The output from an evaluation can vary including, but not limited to: NTP Monograph, state of the science workshop report, or peer-reviewed journal publication. All evaluations follow a similar process with opportunities for external scientific, public, and interagency input.
 7 steps of the NTP Approach for Systematic Review and Evidence Integration for Literature-based Health Assessments are included on the OHAT Evaluation Process schematic in the PDF file with the same name listed above the schematic.
[Download PDF of Schematic]

Systematic Review

In 2012, OHAT began implementing systematic review methodology to carry out these evaluations (Birnbaum et al 2013, Rooney et al. 2014).

OHAT Systematic Review Publications

Systematic review and evidence integration for literature-based environmental health science assessments.
Rooney AA, Boyles AL, Wolfe MS, Bucher JR, Thayer KA. Environ Health Perspect. 2014 Jul;122(7):711-8. doi: 10.1289/ehp.1307972. Epub 2014 Apr 18.
PMID: 24755067

Intersection of Systematic Review Methodology with the NIH Reproducibility Initiative.
Thayer KA, Wolfe MS, Rooney AA, Boyles AL, Bucher JR, Birnbaum LS.
Environ Health Perspect. 2014 Jul 1;122(7):A176-7. doi: 10.1289/ehp.1408671. No abstract available.

Implementing systematic review at the National Toxicology Program: status and next steps.
Birnbaum LS, Thayer KA, Bucher JR, Wolfe MS.
Environ Health Perspect. 2013 Apr;121(4):A108-9. doi: 10.1289/ehp.1306711. No abstract available.
PMID: 23548834

The timeline below shows NTP activities associated with the development of the OHAT approach for systematic review. For more information about the activities, please see the “Events and Activities” webpage.

timeline below shows NTP activities associated with the development of the OHAT approach for systematic review
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.