National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/38138

OHAT Evaluation Process

The NTP Office of Health Assessment and Translation develops literature-based evaluations to reach conclusions about potential human health hazards and to examine the state of the science. The output from an evaluation can vary including, but not limited to: NTP Monograph, state of the science workshop report, or peer-reviewed journal publication. All evaluations follow a similar process with opportunities for external scientific, public, and interagency input. In 2012, OHAT began implementing systematic review methodology to carry out these evaluations (Birnbaum et al 2013, Rooney et al. 2014).
OHAT Evaluation Process Plan for Evaluation Invite topics for evaluation ïScoping (Step 1) Public comment Interagency input Prepare draft concept ïProblem formulation (Step 1) External scientific input Public comment Interagency input Review draft concepts by NTP Board of Scientific Counselors* (public meeting: public comment) NTP Director Develop protocol and start evaluation Conduct Evaluation Prepare draft OHAT Monograph (Steps 2-7) ï Search for and select studies (Step 2) ï Extract data (Step 3) ï Assess individual study quality (Step 4) ï Rate confidence in body of evidence (Step 5)   Input on steps 2-5 (as needed)  ï External scientific  ï Public  ï Interagency  ï Translate confidence ratings into levels of evidence for health effects (Step 6)**  ï Integrate evidence to develop hazard identification conclusions (Step 7)**   Interagency review Complete draft OHAT Monograph Peer Review and Publish OHAT Monograph Release draft OHAT Monograph   Public comment Peer review draft OHAT Monograph by Peer-review panel* (public meeting: public comment) or Ad hoc reviewers (letter review) Present information regarding peer review to NTP Board of Scientific Counselors* NTP Director Publish final OHAT Monograph Steps 1ñ7 refer to the OHAT Approach for Systematic Review and Evidence Integration for Literature-Based Environmental Health Science Assessments; for details see http://ehp.niehs.nih.gov/1307972/ * federally chartered advisory group ** not included in state of science evaluation

Steps 1–7 refer to the OHAT Approach for Systematic Review and Evidence Integration for Literature-Based Environmental Health Science Assessments; for details see http://ehp.niehs.nih.gov/1307972
* federally chartered advisory group
** not included in state of science evaluation


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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.