1978: Congressional Mandate
Section 301(b)(4) of the Public Health Service Act, as amended, requires that the Secretary of the Department of Health and Human Services (DHHS) publish an annual report that contains a list of all substances
1980: 1st RoC published
1993: Annual requirement for report changed to biennial
Since the RoC inception in 1978, the NTP has used scientifically rigorous processes and established listing criteria to evaluate substances for the RoC. The Board of Scientific Counselors (BSC) and the public have provided input leading to several evolutions of the RoC review process and listing criteria. The schematic below describes the key elements of the RoC listing criteria and review processes used for specific editions of the RoC. What follows is a list of some pivotal public events, as well as links to more detailed information, which have helped shaped how substances are evaluated for the RoC.