15th Report on Carcinogens

Flow graphic demonstrating the impact of the Report on Carcinogens

Influence of RoC

A December 2023 paper published in the journal Environmental Health Perspectives (EHP), and an interactive tool demonstrate the Report on Carcinogens’ impact on public health policies.

EHP Publication: An Approach to Assessing the Influence of Environmental and Occupational Cancer Hazard Identification on Policy Decision-Making
EHP Invited Perspective: Good Measure—Assessing the Impact of Cancer Hazard Identification on Policies for Cancer Prevention
Interactive Tool: An online resource to explore and visualize data used in paper
NIEHS Environmental Factor story January 2024: New paper, interactive tool show research influences public health policies

The Report on Carcinogens is a congressionally mandated, science-based public health document that NTP prepares for the U.S. Department of Health and Human Services (HHS) Secretary. This cumulative report now includes 256 listings of substances — chemical, physical, and biological agents; mixtures; and exposure circumstances — that are known or reasonably anticipated to cause cancer in humans. The latest report, the 15th Report on Carcinogens was released on December 21, 2021.

Discover more details about the report and its new listings below. Also, check out the Data Exploration Dashboard, which provides an easy-to-understand visual breakdown of all substances listed in the document and their associated cancers.

Table of Contents
2021 Press Release
Fact Sheet on the 15th Report on Carcinogens
Federal Register notice
Journal Publication (Journal of the National Cancer Institute, August 27, 2022)
- Cancer Hazard Evaluations for Contemporary Needs: Highlights from New National Toxicology Program Evaluations and Methodological Advancements

New Listings

Antimony Trioxide

Haloacetic Acids Found as Water Disinfection By-Products

Helicobacter pylori (H. pylori)

Report on Carcinogens Table of Contents

To search for tumor site and exposure information, see CEBS database

Official Citation: NTP (National Toxicology Program). 2021. Report on Carcinogens, Fifteenth Edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/go/roc15 (EndNote XML)
DOI: https://doi.org/10.22427/NTP-OTHER-1003

Introduction
Review Process
Substances Listed
Substance profiles
Index: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z
- A
- Acetaldehyde
- 2-Acetylaminofluorene
- Acrylamide
- Acrylonitrile
- Adriamycin
- Aflatoxins
- Alcoholic Beverage Consumption
- 2-Aminoanthraquinone
- o-Aminoazotoluene
- 4-Aminobiphenyl
- 1-Amino-2,4-dibromoanthraquinone
- 1-Amino-2-methylanthraquinone
- Amitrole
- o-Anisidine and Its Hydrochloride
- Antimony Trioxide
- Aristolochic Acids
- Arsenic and Inorganic Arsenic Compounds
- Asbestos
- Azacitidine
- Azathioprine
- B
- Basic Red 9 Monohydrochloride
- Benzene
- Benzidine and Dyes Metabolized to Benzidine
  - Benzidine
  - Dyes Metabolized to Benzidine (Benzidine Dye Class)
- Benzotrichloride
- Beryllium and Beryllium Compounds
- 2,2-Bis(bromomethyl)-1,3-propanediol (Technical Grade)
- Bis(chloromethyl) Ether and Technical-Grade Chloromethyl Methyl Ether
- Bromodichloromethane
- 1-Bromopropane
- 1,3-Butadiene
- 1,4-Butanediol Dimethanesulfonate
- Butylated Hydroxyanisole
- C
- Cadmium and Cadmium Compounds
- Captafol
- Carbon Tetrachloride
- Ceramic Fibers (Respirable Size)
- Chlorambucil
- Chloramphenicol
- Chlorendic Acid
- Chlorinated Paraffins (C12, 60% Chlorine)
- Chloroform
- 3-Chloro-2-methylpropene
- 4-Chloro-o-phenylenediamine
- Chloroprene
- p-Chloro-o-toluidine and Its Hydrochloride
- Chromium Hexavalent Compounds
- Cisplatin
- Coal Tars and Coal-Tar Pitches
- Cobalt
  - Cobalt and Cobalt Compounds that Release Cobalt In Vivo
  - Cobalt-Tungsten Carbide: Powders and Hard Metals
- Coke-Oven Emissions
- p-Cresidine
- Cumene
- Cupferron
- Cyclophosphamide
- Cyclosporin A
- D
- Dacarbazine
- Danthron
- 2,4-Diaminoanisole Sulfate
- 2,4-Diaminotoluene
- Diazoaminobenzene
- 1,2-Dibromo-3-chloropropane
- 1,2-Dibromoethane
- 2,3-Dibromo-1-propanol
- 1,4-Dichlorobenzene
- 3,3'-Dichlorobenzidine and Its Dihydrochloride
- Dichlorodiphenyltrichloroethane
- 1,2-Dichloroethane
- Dichloromethane
- 1,3-Dichloropropene (Technical Grade)
- Diepoxybutane
- Diesel Exhaust Particulates
- Di(2-ethylhexyl) Phthalate
- Diethylstilbestrol
- Diethyl Sulfate
- Diglycidyl Resorcinol Ether
- 3,3'-Dimethoxybenzidine and Dyes Metabolized to 3,3'-Dimethoxybenzidine
  - 3,3'-Dimethoxybenzidine
  - Dyes Metabolized to 3,3'-Dimethoxybenzidine (3,3'-Dimethoxybenzidine Dye Class)
- 4-Dimethylaminoazobenzene
- 3,3'-Dimethylbenzidine and Dyes Metabolized to 3,3'-Dimethylbenzidine
  - 3,3'-Dimethylbenzidine
  - Dyes Metabolized to 3,3'-Dimethylbenzidine (3,3'-Dimethylbenzidine Dye Class)
- Dimethylcarbamoyl Chloride
- 1,1-Dimethylhydrazine
- Dimethyl Sulfate
- Dimethylvinyl Chloride
- 1,4-Dioxane
- Disperse Blue
- E
- Epichlorohydrin
- Erionite
- Estrogens, Steroidal
- Ethylene Oxide
- Ethylene Thiourea
- Ethyl Methanesulfonate
- F
- Formaldehyde
- Furan
- G
- Certain Glass Wool Fibers (Inhalable)
- Glycidol
- H
- Haloacetic Acids
- Helicobacter pylori
- Heterocyclic Amines (Selected)
  - 2-Amino-3,4-dimethylimidazo[4,5-f]quinoline
  - 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline
  - 2-Amino-3-methylimidazo[4,5-f]quinoline
  - 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
- Hexachlorobenzene
- Hexachloroethane
- Hexamethylphosphoramide
- Hydrazine and Hydrazine Sulfate
- Hydrazobenzene
- I
- Ionizing Radiation
  - X-Radiation and Gamma Radiation
  - Neutrons
  - Radon
  - Thorium Dioxide
- Iron Dextran Complex
- Isoprene
- J
- K
- Kepone
- L
- Lead and Lead Compounds
- Lindane, Hexachlorocyclohexane (Technical Grade), and Other Hexachlorocyclohexane Isomers
- M
- Melphalan
- Methoxsalen with Ultraviolet A Therapy
- 2-Methylaziridine
- 4,4'-Methylenebis(2-chloroaniline)
- 4,4'-Methylenebis(N,N-dimethyl)benzenamine
- 4,4'-Methylenedianiline and Its Dihydrochloride
- Methyleugenol
- Methyl Methanesulfonate
- Metronidazole
- Michlers Ketone
- Mineral Oils: Untreated and Mildly Treated
- Mirex
- Mustard Gas
- N
- Naphthalene
- 2-Naphthylamine
- Nickel Compounds and Metallic Nickel
  - Nickel Compounds
  - Metallic Nickel
- Nitrilotriacetic Acid
- o-Nitroanisole
- Nitroarenes (Selected)
  - 1,6-Dinitropyrene
  - 1,8-Dinitropyrene
  - 6-Nitrochrysene
  - 1-Nitropyrene
  - 4-Nitropyrene
- Nitrobenzene
- Nitrofen
- Nitrogen Mustard Hydrochloride
- Nitromethane
- 2-Nitropropane
- N-Nitrosamines: 15 Listings
  - N-Methyl-N'-Nitro-N-Nitrosoguanidine
  - N-Nitrosodi-n-butylamine
  - N-Nitrosodiethanolamine
  - N-Nitrosodiethylamine
  - N-Nitrosodimethylamine
  - N-Nitrosodi-n-propylamine
  - N-Nitroso-N-ethylurea
  - 4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
  - N-Nitroso-N-methylurea
  - N-Nitrosomethylvinylamine
  - N-Nitrosomorpholine
  - N-Nitrosonornicotine
  - N-Nitrosopiperidine
  - N-Nitrosopyrrolidine
  - N-Nitrososarcosine
- Nitrosourea Chemotherapeutic Agents
  - Bis(chloroethyl) Nitrosourea
  - 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea
  - 1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea
  - Chlorozotocin
  - Streptozotocin
- o-Nitrotoluene
- Norethisterone
- O
- Ochratoxin A
- 4,4'-Oxydianiline
- Oxymetholone
- P
- Pentachlorophenol and By-products of Its Synthesis
- Phenacetin and Analgesic Mixtures Containing Phenacetin
  - Phenacetin
  - Analgesic Mixtures Containing Phenacetin
- Phenazopyridine Hydrochloride
- Phenolphthalein
- Phenoxybenzamine Hydrochloride
- Phenytoin and Phenytoin Sodium
- Polybrominated Biphenyls
- Polychlorinated Biphenyls
- Polycyclic Aromatic Hydrocarbons: 15 Listings
  - Benz[a]anthracene
  - Benzo[b]fluoranthene
  - Benzo[j]fluoranthene
  - Benzo[k]fluoranthene
  - Benzo[a]pyrene
  - Dibenz[a,h]acridine
  - Dibenz[a,j]acridine
  - Dibenz[a,h]anthracene
  - 7H-Dibenzo[c,g]carbazole
  - Dibenzo[a,e]pyrene
  - Dibenzo[a,h]pyrene
  - Dibenzo[a,i]pyrene
  - Dibenzo[a,l]pyrene
  - Indeno[1,2,3-cd]pyrene
  - 5-Methylchrysene
- Procarbazine and Its Hydrochloride
- Progesterone
- 1,3-Propane Sultone
- β-Propiolactone
- Propylene Oxide
- Propylthiouracil
- Q
- R
- Reserpine
- Riddelliine
- S
- Safrole
- Selenium Sulfide
- Silica, Crystalline (Respirable Size)
- Soots
- Strong Inorganic Acid Mists Containing Sulfuric Acid
- Styrene
- Styrene-7,8-oxide
- Sulfallate
- T
- Tamoxifen
- 2,3,7,8-Tetrachlorodibenzo-p-dioxin
- Tetrachloroethylene
- Tetrafluoroethylene
- Tetranitromethane
- Thioacetamide
- 4,4'-Thiodianiline
- Thiotepa
- Thiourea
- Tobacco-Related Exposures
  - Tobacco Smoking
  - Environmental Tobacco Smoke
  - Smokeless Tobacco
- Toluene Diisocyanates
- o‑Toluidine
- Toxaphene
- Trichloroethylene
- 2,4,6-Trichlorophenol
- 1,2,3-Trichloropropane
- Tris(2,3-dibromopropyl) Phosphate
- U
- Ultraviolet-Radiation-Related Exposures
  - Solar Radiation
  - Exposure to Sunlamps or Sunbeds
  - Broad-Spectrum UVR
  - UVA
  - UVB
  - UVC
- Urethane
- V
- Viruses: Eight Listings
  - Epstein-Barr Virus
  - Hepatitis B Virus
  - Hepatitis C Virus
  - Human Immunodeficiency Virus Type 1
  - Human Papillomaviruses: Some Genital-Mucosal Types
  - Human T-cell Lymphotropic Virus Type 1
  - Kaposi Sarcoma-Associated Herpesvirus
  - Merkel Cell Polyomavirus
- 4-Vinyl-1-cyclohexene Diepoxide
- Vinyl Halides (Selected)
  - Vinyl Bromide
  - Vinyl Chloride
  - Vinyl Fluoride
- W
- Wood Dust
- X - Z
Supplemental Materials and Appendices
Download the complete 15th Report on Carcinogens (24 MB)
Download the CASRN index in MS Excel

Previous Editions

The 15th Report on Carcinogens is the latest edition published December 2021 and replaces any previous report.

The U.S. Department of Commerce's National Technical Information Service (NTIS) may have copies of previous versions of the Report on Carcinogens.

To find a specific edition of the report, search for publication number, at the NTIS website (https://www.ntis.gov). Alternatively, you can contact NTIS at 800-553-6847 or 703-605-6000.

NTIS Publication Numbers
Edition	Publication Number (PB Number)
1st	PB84122852 Volume I; PB84122860 Volume II
2nd	PB82229808
3rd	PB83135855
4th	PB85134633
5th	PB89231914
6th	PB92120666 Volume I and II
7th	PB95109781
8th	PB99128746 Volume I and II
9th	PB2000107509
10th	PB2013100250
11th	PB2005104914
12th	PB2011111646
13th	PB2015500015
14th

For questions or additional information, contact:

NTP Web Team
P.O. Box 12233, MD K2-05
Research Triangle Park, NC 27709
Telephone: 984-287-3211
Email us or use our contact form