National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/rocnom

Substances Nominated to the Report on Carcinogens

This list shows substances that have been nominated to the RoC, but have not yet been approved for formal review. See the Candidate Substances list for substances that have been selected and are currently under review.

You can provide additional information on any of the nominated substances (such as citations or new studies, scientific issues, and nomination of experts).


 

General Public Comments


Index: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z


A

Alkenylbenzenes (selected dietary: estragole, myristicin, isosafrole)
CASRN 140-67-0 (estragole), CASRN 607-91-0 (myristicin), and CASRN 120-58-1 (isosafrole)

  • Primary Uses or Exposures: Naturally occurring organic chemicals used primarily as an additive, flavoring, or fragrance in food products, but may also be in other products such as cosmetic and cleaning agents.
  • Federal Register notice – January 19, 2012 (PDF HTML)
  • Public Comments

Aloe vera whole leaf extract (Aloe barbadensis Miller) 

  • Primary Uses or Exposures: Herbal remedy (botanical product) used in a variety of health care products and cosmetics.
  • Federal Register notice – September 20, 2013 (PDF HTML)
  • Public Comments

Back to Top


B

2-Butoxyethanol 
CASRN 111-76-2

  • Primary Uses or Exposures: Ethylene glycol monoalkyl ether used as a solvent in cleaning products and dispersants for industrial and consumer applications.
  • Federal Register notice – September 20, 2013 (PDF HTML)
  • Public Comments

Back to Top


C

Carbon black 
CASRN 1333-86-4

  • Primary Uses or Exposures: Family of products consisting of elemental carbon in the form of colloidal particles that rapidly form aggregates. The products are used primarily for rubber reinforcement, but are also used as black pigments and for electrical conductivity purposes.
  • Federal Register notice – January 19, 2012 (PDF HTML)
  • Public Comments

Chlorothalonil (2,4,5,6-tetrachloro-isophthalonitrile) 
CASRN 1897-45-6

  • Primary Uses or Exposures: A broad-spectrum pesticide used on a variety of vegetable and orchard crops. It is also used as a mildewicide added to paint and other surfaces.
  • Federal Register notice – September 20, 2013 (PDF HTML)
  • Public Comments

Coconut diethanolamide
CASRN 68603-42-9

  • Primary Uses or Exposures: Component (foam stabilizer) in consumer products (e.g., shampoos and dishwashing liquids). Also a component in some metalworking fluids.
  • Federal Register notice – September 20, 2013 (PDF HTML)
  • Public Comments

Back to Top


D

Decalin 
CASRN 91-17-8

  • Primary Uses or Exposures: Industrial solvent primarily for naphthalene, fats, resins, oils, and waxes.
  • Federal Register notice – September 20, 2013 (PDF HTML)
  • Public Comments

Diesel exhaust particulates

  • Primary Uses or Exposures: A mixture of combustion products of diesel fuel; the exact composition of the mixture depends on the nature of the engine, operating conditions, lubricating oil, additives, emission control system, and fuel composition. Occupational exposure occurs primarily among miners (who use diesel power equipment), railroad workers and transportation workers such as truck drivers.
  • Currently listed as Reasonably Anticipated to be a Human Carcinogen in the 12th RoC
  • Federal Register notice – January 19, 2012 (PDF HTML)
  • Public Comments

Back to Top


E

Ethylbenzene 
CASRN 100-41-4

  • Primary Uses or Exposures: An alkylated benzene used primarily for the manufacture of styrene.
  • Federal Register notice – January 19, 2012 (PDF HTML)
  • Public Comments

Back to Top


F

None

Back to Top


G

Ginkgo biloba extract

  • Primary Uses or Exposures: Herbal remedy (botanical product) used primarily in the treatment or prevention of cardiovascular and cerebrovascular dysfunction.
  • Federal Register notice – September 20, 2013 (PDF HTML)
  • Public Comments

Back to Top


H

Helicobacter pylori 

  • Primary Uses or Exposures: Bacteria responsible for most ulcers and many cases of stomach inflammation (chronic gastritis).
  • Federal Register notice – January 19, 2012 (PDF HTML)>
  • Public Comments

Back to Top


I

Indium compounds 

  • Primary Uses or Exposures: Indium compounds are chemicals that include the metal indium. Indium phosphide is used primarily in the semiconductor industry; however, most of the semiconductor industry in the U.S. is silicon based. Other indium compounds (such as indium tin oxide) are primarily used in optoelectronics and flat panel display technology.
  • Federal Register notice – January 19, 2012 (PDF HTML)
  • Public Comments

Iron (excess) or iron overload 
CASRN 7439-89-6 (elemental iron)

  • Primary Uses or Exposures: Iron is a transition metal that exists mainly in the ferrous (2+) and ferric (3+) oxidation states in biological systems. It is used for medical treatment, as well as for other consumer and industrial needs. It is also found naturally in food. Iron overload disorders can be hereditary, acquired or iatrogenic.
  • Federal Register notice – January 19, 2012 (PDF HTML)
  • Public Comments

Back to Top


J

None

Back to Top


K

Kava kava extract 

  • Primary Uses or Exposures: Herbal remedy (botanical product) used as an alternative to anti-anxiety drugs or for hyperactivity in children, and as a skin-condition agent in cosmetics. Roots used in kava beverages, which have sedative and anesthetic properties.
  • Federal Register notice – September 20, 2013 (PDF HTML)
  • Public Comments

Back to Top


L

None

Back to Top


M

2-Methylimidazole 
CASRN 693-98-1

  • Primary Uses or Exposures: Used in the manufacture of pharmaceuticals, photographic chemicals, dyes and pigments, agricultural chemicals, and rubber. Also found in tobacco smoke.
  • Federal Register notice – September 20, 2013 (PDF HTML)
  • Public Comments

4-Methylimidazole 
CASRN 822-36-6<</p>

  • Primary Uses or Exposures: Used in the manufacture of pharmaceuticals, photographic chemicals, dyes and pigments, cleaning and agricultural chemicals, and rubber. Also found in tobacco smoke and food and drinks containing caramel coloring.
  • Federal Register notice – September 20, 2013 (PDF HTML)
  • Public Comments

Methyl isobutyl ketone 
CASRN 108-10-1

  • Primary Uses or Exposures: Solvent for paints, varnishes and other agents, and for industrial extraction processes. Also denaturant for rubbing alcohol.
  • Federal Register notice – September 20, 2013 (PDF HTML)
  • Public Comments

Back to Top


N

Nickel nanoparticles 

  • Primary Uses or Exposures: Used as a catalyst, gas sensor, alkaline battery cathode, electro-chromic film, magnetic material and fuel cell.
  • Federal Register notice – September 20, 2013 (PDF HTML)
  • Public Comments

Nitro PAHs as a class 

  • Primary Uses or Exposures: Found in particulate emissions from many combustion sources, most notably, diesel exhaust.
  • Federal Register notice – September 20, 2013 (PDF HTML)
  • Public Comments

Back to Top


O

None

Back to Top


P

Perfluorooctanoic acid (PFOA)
CASRN 335-67-1

  • Primary Uses or Exposures: Used in the manufacturing of fluoropolymers. Fluoropolymers are primarily used to provide non-stick to cookware and waterproof membranes for clothing. They are also used in other applications and have fire-resistance properties.
  • Federal Register notice – September 20, 2013 (PDF HTML)
  • Public Comments

Polyacrylates

  • Primary Uses or Exposures: Manufacture of absorbing gel materials (diapers), cosmetics, agricultural products, thickening agents, household products.
  • Federal Register notice – September 20, 2013 (PDF HTML)
  • Public Comments

Pulegone 
CASRN 89-82-7

  • Primary Uses or Exposures: Used for flavoring foods, drinks, and dental products.
  • Federal Register notice – September 20, 2013 (PDF HTML)
  • Public Comments

Back to Top


Q

None

Back to Top


R

None

Back to Top


S

None

Back to Top


T

Tetralin 
CASRN 119-64-2

  • Primary Uses or Exposures: Industrial solvent, primarily for naphthalene, paints, waxes and polishes, also used as a solvent for pesticides, asphalt and aromatic hydrocarbons.
  • Federal Register notice – September 20, 2013 (PDF HTML)
  • Public Comments

Tris-(1,3-dichloro-2-propyl) phosphate (TDCPP) 
CASRN 13674-87-8

  • Primary Uses or Exposures: Organophosphate flame retardant used in the polyurethane foam padding in furniture and automobiles.
  • Federal Register notice – September 20, 2013 (PDF HTML)
  • Public Comments

Back to Top


U

Uranium (depleted) 

  • Primary Uses or Exposures: Depleted uranium (DU) is a byproduct of the production of enriched uranium for use in nuclear reactors. It has a lower content of the isotope U-235 and emits fewer alpha particles than natural uranium. Because of its high density, the military uses DU for armor-piercing munitions and armor plates. It has also been used as counterbalance weight in aircraft, and radiation shielding in medical radiation therapy.
  • Federal Register notice – January 19, 2012 (PDF HTML)
  • Public Comments

Back to Top


V

None

Back to Top


W

Wood smoke 

  • Primary Uses or Exposures: Smoke from wood burning fireplaces and stoves.
  • Federal Register notice – September 20, 2013 (PDF HTML)
  • Public Comments

Back to Top


X

None

Back to Top


Y

None

Back to Top


Z

None



Note on Accessibility: Persons with disabilities or using assistive technology may find some documents are not fully accessible. For assistance, contact us by emailing Central Data Management (or calling 919-541-3419) and identify the documents/pages for which access is required. We will assist you in accessing the content of these files. The NIEHS has helpful information on accessibility.

NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.