National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/rocnom

Substances Nominated to the Report on Carcinogens

This list shows substances that have been nominated to the RoC, but have not yet been approved for formal review. Click here to see the list of selected substances that are currently under review (i.e., candidate substances).

You can provide information on any of the nominated substances (such as citations or new studies, scientific issues, and nomination of experts).  

New Nominations (Federal Register notice – September 9, 2016 (PDF HTML)):


Index: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z


A

Alkenylbenzenes (selected dietary: estragole, myristicin, isosafrole)
CASRN 140-67-0 (estragole), CASRN 607-91-0 (myristicin), and CASRN 120-58-1 (isosafrole)

  • Primary Uses or Exposures: Naturally occurring organic chemicals used primarily as an additive, flavoring, or fragrance in food products, but may also be in other products such as cosmetic and cleaning agents.
  • Federal Register notice – January 19, 2012 (PDF HTML)
  • Public Comments

Antimony trioxide
CASRN 1309-64-4

  • Primary Uses or Exposures: Antimony trioxide is a natural component of the earth crust. Antimony trioxide is the most commercially significant form of antimony. Antimony trioxide is used mainly in fire-retardant formulations for plastics, rubbers, textiles, paper and paints and in combination with other flame retardants on furniture, draperies, wall covers, carpets, and printed circuit boards. It is also used in the electronic industry and as an additive in glass and ceramic products and as a catalyst in the chemical industry.
  • Federal Register notice – September 9, 2016 (PDF HTML)
  • Public Comments

Index: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z


B

None


C

Carbon black 
CASRN 1333-86-4

  • Primary Uses or Exposures: Family of products consisting of elemental carbon in the form of colloidal particles that rapidly form aggregates. The products are used primarily for rubber reinforcement, but are also used as black pigments and for electrical conductivity purposes.
  • Federal Register notice – January 19, 2012 (PDF HTML)
  • Public Comments

Chlorothalonil (2,4,5,6-tetrachloro-isophthalonitrile) 
CASRN 1897-45-6

  • Primary Uses or Exposures: A broad-spectrum pesticide used on a variety of vegetable and orchard crops. It is also used as a mildewicide added to paint and other surfaces.
  • Federal Register notice – September 20, 2013 (PDF HTML)
  • Public Comments

Index: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z


D

Decalin 
CASRN 91-17-8

  • Primary Uses or Exposures: Industrial solvent primarily for naphthalene, fats, resins, oils, and waxes.
  • Federal Register notice – September 20, 2013 (PDF HTML)
  • Public Comments

Dibromoacetonitrile
CASRN 3252-43-5

  • Primary Uses or Exposures: Water disinfection byproduct (haloactonitrile) formed as a result of the reaction of chlorine oxidizing compounds with natural organic matter found in drinking water.
  • Federal Register notice – October 7, 2015 (PDF HTML)
  • Public Comments

Diesel exhaust particulates

  • Primary Uses or Exposures: A mixture of combustion products of diesel fuel; the exact composition of the mixture depends on the nature of the engine, operating conditions, lubricating oil, additives, emission control system, and fuel composition. Occupational exposure occurs primarily among miners (who use diesel power equipment), railroad workers and transportation workers such as truck drivers.
  • Currently listed as Reasonably Anticipated to be a Human Carcinogen in the 12th RoC
  • Federal Register notice – January 19, 2012 (PDF HTML)
  • Public Comments

Index: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z


E

Ethylbenzene 
CASRN 100-41-4

  • Primary Uses or Exposures: An alkylated benzene used primarily for the manufacture of styrene.
  • Federal Register notice – January 19, 2012 (PDF HTML)
  • Public Comments

Index: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z


F

Flame retardants

Pentabromodiphenyl ether mixture (DE-71)
CASRN 32534-81-9

  • Primary Uses or Exposures: Flame retardant mixture used in furniture materials; voluntarily phased out in the United States in 2004. Widespread occurrence in the environment.
  • Federal Register notice – October 7, 2015 (PDF HTML)
  • Public Comments

Tetrabromobisphenol A (TBBPA)
CASRN 79-94-7

  • Primary Uses or Exposures: Brominated flame retardant used in circuit boards, to encapsulate electronics, and intermediate for other flame retardants.
  • Federal Register notice – October 7, 2015 (PDF HTML)
  • Public Comments

Fluoride

  • Primary Uses or Exposures: Mineral primarily used to prevent tooth decay; added to municipal water supplies and dental products (e.g., toothpaste). Primary exposure to public is via drinking water and use of fluorinated products. Workers may be exposed by inhaling fluoride dust.
  • Federal Register notice – October 7, 2015 (PDF HTML)
  • Public Comments

Index: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z


G - H

None


I

Indium compounds 

  • Primary Uses or Exposures: Indium compounds are chemicals that include the metal indium. Indium phosphide is used primarily in the semiconductor industry; however, most of the semiconductor industry in the U.S. is silicon based. Other indium compounds (such as indium tin oxide) are primarily used in optoelectronics and flat panel display technology.
  • Federal Register notice – January 19, 2012 (PDF HTML)
  • Public Comments

Iron (excess) or iron overload 
CASRN 7439-89-6 (elemental iron)

  • Primary Uses or Exposures: Iron is a transition metal that exists mainly in the ferrous (2+) and ferric (3+) oxidation states in biological systems. It is used for medical treatment, as well as for other consumer and industrial needs. It is also found naturally in food. Iron overload disorders can be hereditary, acquired or iatrogenic.
  • Federal Register notice – January 19, 2012 (PDF HTML)
  • Public Comments

Index: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z


J - L

None


M

Meat-related exposures

  • Federal Register notice – September 9, 2016 (PDF HTML)
  • Public Comments

Consumption of red meat

  • Primary Uses or Exposures: Red meat refers to meat that has more red than white fibers such as beef, goat, lamb and pork. People are exposed to red and processed meat in their daily diet. In the United States, daily total meat intake is 128 g, of which 55% is red meat.

Consumption of processed meat

  • Primary Uses or Exposures: Processed meat is meat that is preserved by smoking, curing, salting and adding chemical preservatives. In the United States, daily processed meat is estimated to be 23 g.

Consumption of meat cooked at high temperatures

  • Primary Uses and Exposure: Cooking meat at high temperatures refers to cooking methods including grilling and pan frying as well as the final cooking temperature or ‘doneness’ of the meat. High temperature cooking methods lead to the formation of many chemical substances including heterocyclic amines (HCAs) and polycyclic aromatic hydrocarbons (PAHs).

2-Methylimidazole 
CASRN 693-98-1

  • Primary Uses or Exposures: Used in the manufacture of pharmaceuticals, photographic chemicals, dyes and pigments, agricultural chemicals, and rubber. Also found in tobacco smoke.
  • Federal Register notice – September 20, 2013 (PDF HTML)
  • Public Comments

4-Methylimidazole 
CASRN 822-36-6

  • Primary Uses or Exposures: Used in the manufacture of pharmaceuticals, photographic chemicals, dyes and pigments, cleaning and agricultural chemicals, and rubber. Also found in tobacco smoke and food and drinks containing caramel coloring.
  • Federal Register notice – September 20, 2013 (PDF HTML)
  • Public Comments

Methyl isobutyl ketone 
CASRN 108-10-1

  • Primary Uses or Exposures: Solvent for paints, varnishes and other agents, and for industrial extraction processes. Also denaturant for rubbing alcohol.
  • Federal Register notice – September 20, 2013 (PDF HTML)
  • Public Comments

Index: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z


N

Nitro PAHs as a class 

  • Primary Uses or Exposures: Found in particulate emissions from many combustion sources, most notably, diesel exhaust.
  • Federal Register notice – September 20, 2013 (PDF HTML)
  • Public Comments

Index: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z


O

None


P

Pentabromodiphenyl ether mixture (DE-71) [see Flame retardants]

Perfluorooctanoic acid (PFOA)
CASRN 335-67-1

  • Primary Uses or Exposures: Used in the manufacturing of fluoropolymers. Fluoropolymers are primarily used to provide non-stick to cookware and waterproof membranes for clothing. They are also used in other applications and have fire-resistance properties.
  • Federal Register notice – September 20, 2013 (PDF HTML)
  • Public Comments

Index: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z


Q - S

None


T

Tetrabromobisphenol A (TBBPA) [see Flame retardants]

Tris-(1,3-dichloro-2-propyl) phosphate (TDCPP) 
CASRN 13674-87-8

  • Primary Uses or Exposures: Organophosphate flame retardant used in the polyurethane foam padding in furniture and automobiles.
  • Federal Register notice – September 20, 2013 (PDF HTML)
  • Public Comments

Index: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z


U

None


V

Vinylidene chloride
CASRN 75-35-4

  • Primary Uses or Exposures: Chemical intermediate used to make a variety of polymers that are used to make consumer products (e.g., plastic food packaging films, binders).
  • Federal Register notice – October 7, 2015 (PDF HTML)
  • Public Comments

Index: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z


W

Wood smoke 

  • Primary Uses or Exposures: Smoke from wood burning fireplaces and stoves.
  • Federal Register notice – September 20, 2013 (PDF HTML)
  • Public Comments

Index: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z


X - Z

NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.