National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/15837

Historical Controls

NTP has gathered a significant database of results collected on toxicity studies. To follow changes in the biology of our test species and also as an additional way to evaluate test results, we maintain a historical summary of the observations made on the untreated or control groups from individual studies as follows:

  • Tumor incidences and growth and survival curves for control animals from NTP's two-year carcinogenesis studies are summarized by species, sex, route of administration, and vehicle.
  • The data for control animals fed the NTP-2000 Diet are periodically updated and compiled from the most recent five-year period of results.
  • The data for control animals fed the NIH-07 Diet were compiled from the most recent studies (usually a five-year period) through 1995, when NTP switched to the NTP-2000 diet.

Note: The historical controls data for genetically modified models are displayed separately.

Learn the history of rat models used by NTP

Commentary: Update on Animal Models for NTP Studies contains a thorough discussion on rat strain selection considerations. The following history summarizes part of the discussion.

For more than 30 years, NTP used the inbred F344/N rat for toxicity and carcinogenicity studies. Over time, this substrain developed decreased fecundity, sporadic seizures, and idiopathic chylothorax. The F344/N possessed other health issues inherent to the strain including high rates of mononuclear cell leukemia and testicular neoplasia.

In 2005, NTP held the NTP Workshop: Animal Models for the NTP Rodent Cancer Bioassay: Stocks and Strains – Should we Switch?. Workshop participants recommended three options to NTP:

  • Establish another colony of the F344 rat from another source,
  • use an F1 hybrid, or
  • use an outbred stock of rat such as the Wistar Han or the Sprague Dawley.

NTP initially switched to the F344/NTac rat. This temporary change enabled NTP time to continue planned studies while exploring other rat models. NTP determined that a common default rat model to be used across study types would be useful.

NTP selected the Wistar Han rat as the default model as it was projected to have a long life span, resistance to disease, large litter size, and low neonatal mortality. However, in several studies with perinatal exposure, the average litter sizes were smaller than expected, the litters had a high variability in sex distribution, and pregnancy rates in time mated Wistar Han rats were not acceptable.

Consequently, NTP adopted the Harlan Sprague Dawley rat as the default NTP rat strain. NTP's decision came after much deliberation including consideration of historical data from eight previous NTP cancer studies using the female Sprague Dawley rat, and very favorable data on litter size, sex ratio, and body weight.


Tables and Curves

In the pathology tables, tumor incidence is defined as the number of animals exhibiting a particular tumor type divided by the number of animals examined and is expressed as both raw counts and percent. The pathology tables present the mean, standard deviation, and range of tumor incidence among studies, along with the number of studies summarized and the date when the historical database was most recently updated.

  • The growth curves present the mean growth for each route/species/sex group of control animals along with the 5th and 95th percentile.
  • The survival curves present the mean survival for each route/species/sex group of control animals along with the 5th and 95th percentile.
  • The summary of tumor incidence in control animals is updated annually or semi-annually depending on the number of studies completed.

Table of Historical Controls

How to search with filtering and sorting

Search for particular tables by filtering or sorting the table. As you begin to type your search entry, the page will filter the table results by text. For example, type "F344" to see Fischer F344/N Rats rows.

To sort the table by a specific column, click the up/down filter arrow in the table header for that column. When clicked, the column headers will sort the table by ascending or descending order. If only one arrow is displayed, that column is sorted in the direction of the arrow. To sort more than one column, click the first column header, and then hold the shift key and click on additional column headers.

Year Posted Species: Strain Diet Years Study Started All Routes/Vehicles Pathology Tables by Route/Vehicle Growth Curves By Route/Vehicle Survival Curves By Route/Vehicle
2016 Mice: B6C3F1 NTP-2000 2006-2011 Pathology Tables for All Routes/Vehicles
Body Weights for All Routes/Vehicles
Survival Curves for All Routes/Vehicles
Routes/Vehicles Chemicals by Sex/Species/Route/Vehicle
Pathology Tables by Route/Vehicle Gavage/Corn Oil
Gavage/Water
Inhalation/Air
Oral/Water
Gavage/Corn Oil
Gavage/Water
Inhalation/Air
Oral/Water
2016 Rats: Wistar Han NTP-2000 2007-2009 Pathology Tables for All Routes/Vehicles
Body Weights for All Routes/Vehicles
Survival Curves for All Routes/Vehicles
Routes/Vehicles Chemicals by Sex/Species/Route/Vehicle
Pathology Tables by Route/Vehicle Gavage/Corn Oil
Gavage/Water
Inhalation/Air
Gavage/Corn Oil
Gavage/Water
Inhalation/Air
2016 Rats: Harlan Sprague-Dawley NTP-2000 2007-2011 Pathology Tables for All Routes/Vehicles
Body Weights for All Routes/Vehicles
Survival Curves for All Routes/Vehicles
Routes/Vehicles Chemicals by Sex/Species/Route/Vehicle
Pathology Tables by Route/Vehicle Gavage/Corn Oil
Inhalation/Air
Gavage/Corn Oil
Inhalation/Air
2015 Mice: B6C3F1 NTP-2000 2005-2009 Pathology Tables for All Routes/Vehicles
Body Weights for All Routes/Vehicles
Survival Curves for All Routes/Vehicles
Chemicals by Sex/Species/Route/Vehicle
Pathology Tables by Route/Vehicle Gavage/Corn Oil
Gavage/Water
Inhalation/Air
Oral/Water
Gavage/Corn Oil
Gavage/Water
Inhalation/Air
Oral/Water
2015 Rats: Wistar Han NTP-2000 Note: See tables posted in 2014 as no new rat studies were added.
2014 Rats: Wistar Han NTP-2000 2007-2008 Pathology Tables for All Routes/Vehicles
Body Weights for All Routes/Vehicles
Survival Curves for All Routes/Vehicles
Chemicals by Sex/Species/Route/Vehicle
Pathology Tables by Route/Vehicle
Gavage/Corn Oil
Gavage/Water
Inhalation/Air
Gavage/Corn Oil
Gavage/Water
Inhalation/Air
 
Gavage/Corn Oil
Gavage/Water
Inhalation/Air
 
2014 Mice: B6C3F1 NTP-2000 2004-2008 Pathology Tables for All Routes/Vehicles
Body Weights for All Routes/Vehicles
Survival Curves for All Routes/Vehicles
Chemicals by Sex/Species/Route/Vehicle
Pathology Tables by Route/Vehicle
Skin Application/Acetone
Skin Application/Ethanol
Gavage/Corn Oil
Gavage/Water
Inhalation/Air
Oral/Water
Skin Application/Acetone
Skin Application/Ethanol
Gavage/Corn Oil
Gavage/Water
Inhalation/Air
Oral/Water
 
Skin Application/Acetone
Skin Application/Ethanol
Gavage/Corn Oil
Gavage/Water
Inhalation/Air
Oral/Water
2013 Rats: Fischer344N NTP-2000 2003-2005 Pathology Tables for All Routes/Vehicles
Body Weights for All Routes/Vehicles
Survival Curves for All Routes/Vehicles
Chemicals by Sex/Species/Route/Vehicle
Pathology Tables by Route/Vehicle
Skin Application/Acetone
Skin Application/Ethanol
Gavage/Corn Oil
Gavage/Methyl Cellulose
Gavage/Water
Inhalation/Air
Oral/Feed
Oral/Water
Skin Application/Acetone
Skin Application/Ethanol
Gavage/Corn Oil
Gavage/Methyl Cellulose
Gavage/Water
Inhalation/Air
Oral/Feed
Oral/Water
 
Skin Application/Acetone
Skin Application/Ethanol
Gavage/Corn Oil
Gavage/Methyl Cellulose
Gavage/Water
Inhalation/Air
Oral/Feed
Oral/Water
2013 Rats: Fischer 344/NTac NTP-2000 2006 Pathology Tables for All Routes/Vehicles
Body Weights for All Routes/Vehicles
Survival Curves for All Routes/Vehicles
Chemicals by Sex/Species/Route/Vehicle
Pathology Tables by Route/Vehicle
Inhalation/Air
Oral/Water
 
Inhalation/Air
Oral/Water
 
Inhalation/Air
Oral/Water
 
2013 Rats: Wistar Han NTP-2000 2007-2008 Pathology Tables for All Routes/Vehicles
Body Weights for All Routes/Vehicles
Survival Curves for All Routes/Vehicles
Chemicals by Sex/Species/Route/Vehicle
Pathology Tables by Route/Vehicle
Gavage/Corn Oil
Gavage/Water
Inhalation/Air
Gavage/Corn Oil
Gavage/Water
Inhalation/Air
 
Gavage/Corn Oil
Gavage/Water
Inhalation/Air
 
2013 Rats: Harlan Sprague-Dawley NTP-2000 2004-2007 Pathology Tables for All Routes/Vehicles
Body Weights for All Routes/Vehicles
Survival Curves for All Routes/Vehicles
Chemicals by Sex/Species/Route/Vehicle
Pathology Tables by Route/Vehicle
Gavage/Corn Oil
 
Gavage/Corn Oil
 
Gavage/Corn Oil
 
2013 Mice: B6C3F1 NTP-2000 2003-2008 Pathology Tables for All Routes/Vehicles
Body Weights for All Routes/Vehicles
Survival Curves for All Routes/Vehicles
Chemicals by Sex/Species/Route/Vehicle
Pathology Tables by Route/Vehicle
Skin Application/Acetone
Skin Application/Ethanol
Gavage/Corn Oil
Gavage/Methyl Cellulose
Gavage/Water
Inhalation/Air
Oral/Water
 
Skin Application/Acetone
Skin Application/Ethanol
Gavage/Corn Oil
Gavage/Methyl Cellulose
Gavage/Water
Inhalation/Air
Oral/Water
 
Skin Application/Acetone
Skin Application/Ethanol
Gavage/Corn Oil
Gavage/Methyl Cellulose
Gavage/Water
Inhalation/Air
Oral/Water
 
2011 Rats: Fischer F344/N NTP-2000 2002-2005 Pathology Tables for All Routes/Vehicles
Body Weights for All Routes/Vehicles
Survival Curves for All Routes/Vehicles
Chemicals by Sex/Species/Route/Vehicle
Pathology Tables by Route/Vehicle
Gavage/Corn Oil
Gavage/Methyl Cellulose
Gavage/Water
Inhalation/Air
Oral/Feed
Oral/Water
Skin Application/Acetone
Skin Application/Ethanol

Perinatal and Postnatal:
Oral/Feed
Gavage/Corn Oil
Gavage/Methyl Cellulose
Gavage/Water
Inhalation/Air
Oral/Feed
Oral/Water
Oral/Feed
Skin Application/Acetone
Skin Application/Ethanol

Perinatal and Postnatal:
Oral/Feed
Gavage/Corn Oil
Gavage/Methyl Cellulose
Gavage/Water
Inhalation/Air
Oral/Feed
Oral/Water
Skin Application/Acetone
Skin Application/Ethanol

Perinatal and Postnatal:
Oral/Feed
2011 Rats: Harlan Sprague-Dawley NTP-2000 2003-2004 Pathology Tables for All Routes/Vehicles
Body Weights for All Routes/Vehicles
Survival Curves for All Routes/Vehicles
Chemicals by Sex/Species/Route/Vehicle
Pathology Tables by Route/Vehicle
Gavage/Corn Oil
Gavage/Corn Oil Gavage/Corn Oil
2011 Mice: B6C3F1 NTP-2000 2002-2005 Pathology Tables for All Routes/Vehicles
Body Weights for All Routes/Vehicles
Survival Curves for All Routes/Vehicles
Chemicals by Sex/Species/Route/Vehicle
Pathology Tables by Route/Vehicle
Gavage/Corn Oil
Gavage/Methyl Cellulose
Gavage/Water
Inhalation/Air
Oral/Feed
Oral/Water
Skin Application/Ethanol
Gavage/Corn Oil
Gavage/Methyl Cellulose
Gavage/Water
Inhalation/Air
Oral/Feed
Oral/Water
Skin Application/Ethanol
 
Gavage/Corn Oil
Gavage/Methyl Cellulose
Gavage/Water
Inhalation/Air
Oral/Feed
Oral/Water
Skin Application/Ethanol
 
2010 Rats: Fischer F344/N NTP-2000 2001-2005 Pathology Tables for All Routes/Vehicles
Body Weights for All Routes/Vehicles
Survival Curves for All Routes/Vehicles
Chemicals by Sex/Species/Route/Vehicle
Pathology Tables by Route/Vehicle
Gavage/Corn Oil
Gavage/Methyl Cellulose
Gavage/Water
Inhalation/Air
Oral/Feed
Oral/Water
Skin Application/Acetone
Skin Application/Ethanol
 
Gavage/Corn Oil
Gavage/Methyl Cellulose
Gavage/Water
Inhalation/Air
Oral/Feed
Oral/Water
Skin Application/Acetone
Skin Application/Ethanol
 
Gavage/Corn Oil
Gavage/Methyl Cellulose
Gavage/Water
Inhalation/Air
Oral/Feed
Oral/Water
Skin Application/Acetone
Skin Application/Ethanol
 
2010 Mice: B6C3F1 NTP-2000 2001-2004 Pathology Tables for All Routes/Vehicles
Body Weights for All Routes/Vehicles
Survival Curves for All Routes/Vehicles
Chemicals by Sex/Species/Route/Vehicle
Pathology Tables by Route/Vehicle
Gavage/Corn Oil
Gavage/Methyl Cellulose
Gavage/Water
Inhalation/Air
Oral/Feed
Oral/Water
Skin Application/Ethanol
Gavage/Corn Oil
Gavage/Methyl Cellulose
Gavage/Water
Inhalation/Air
Oral/Feed
Oral/Water
Skin Application/Ethanol
Gavage/Corn Oil
Gavage/Methyl Cellulose
Gavage/Water
Inhalation/Air
Oral/Feed
Oral/Water
Skin Application/Ethanol
2009 Rats: Fischer F344/N NTP-2000 2000-2004 Pathology Tables for All Routes/Vehicles
Body Weights for All Routes/Vehicles
Survival Curves for All Routes/Vehicles
Chemicals by Species/Route/Vehicle
Pathology Tables by Route/Vehicle
Gavage/Corn Oil
Gavage/Methyl Cellulose
Gavage/Water
Inhalation/Air
Oral/Feed
Oral/Water
Skin Application/Ethanol
Gavage/Corn Oil
Gavage/Methyl Cellulose
Gavage/Water
Inhalation/Air
Oral/Feed
Oral/Water
Skin Application/Ethanol
Gavage/Corn Oil
Gavage/Methyl Cellulose
Gavage/Water
Inhalation/Air
Oral/Feed
Oral/Water
Skin Application/Ethanol
2009 Mice: B6C3F1 NTP-2000 2000-2004 Pathology Tables for All Routes/Vehicles
Body Weights for All Routes/Vehicles
Survival Curves for All Routes/Vehicles
Chemicals by Species/Route/Vehicle
Pathology Tables by Route/Vehicle
Gavage/Corn Oil
Gavage/Methyl Cellulose
Gavage/Water
Inhalation/Air
Oral/Feed
Oral/Water
Skin Application/Ethanol
Gavage/Corn Oil
Gavage/Methyl Cellulose
Gavage/Water
Inhalation/Air
Oral/Feed
Oral/Water
Skin Application/Ethanol
Gavage/Corn Oil
Gavage/Methyl Cellulose
Gavage/Water
Inhalation/Air
Oral/Feed
Oral/Water
Skin Application/Ethanol
2008 Rats: Harlan Sprague-Dawley NTP-2000 1998-2004 Pathology Tables for All Routes/Vehicles
Note: These reports cover more than five years so that all
the Toxic Equivalency Factor studies would be included.
Gavage/Corn Oil Gavage/Corn Oil Gavage/Corn Oil
1999 Mice: B6C3F1 NIH-07 1984-1994 Pathology Tables for All Routes/Vehicles
Growth Curves for All Routes/Vehicles
Survival Curves for All Routes/Vehicles
Chemicals by Species/Route/Vehicle
Dermal/Acetone
Dermal/Ethanol
Gavage/Corn Oil
Gavage/Methyl Cellulose
Gavage/Water
Inhalation/Air
Oral/Feed
Oral/Water
Subcutaneous/Buffered Serum
Vaginal/Water
Dermal/Acetone
Dermal/Ethanol
Gavage/Corn Oil
Gavage/Methyl Cellulose
Gavage/Water
Inhalation/Air
Oral/Feed
Oral/Water
Subcutaneous/Buffered Serum
Vaginal/Water
Dermal/Acetone
Dermal/Ethanol
Gavage/Corn Oil
Gavage/Methyl Cellulose
Gavage/Water
Inhalation/Air
Oral/Feed
Oral/Water
Subcutaneous/Buffered Serum
Vaginal/Water
1999 Rats: Fischer F344 NIH-07 1984-1994 Pathology Tables for All Routes/Vehicles
Growth Curves for All Routes/Vehicles
Survival Curves for All Routes/Vehicles
Chemicals by Species/Route/Vehicle
Dermal/Acetone
Dermal/Ethanol
Dermal/Neat
Gavage/Corn Oil
Gavage/Methyl Cellulose
Gavage/Water
Inhalation/Air
Oral/Feed
Oral/Water
Dermal/Acetone
Dermal/Ethanol
Dermal/Neat
Gavage/Corn Oil
Gavage/Methyl Cellulose
Gavage/Water
Inhalation/Air
Oral/Feed
Oral/Water
Dermal/Acetone
Dermal/Ethanol
Dermal/Neat
Gavage/Corn Oil
Gavage/Methyl Cellulose
Gavage/Water
Inhalation/Air
Oral/Feed
Oral/Water
1998 Mice: B6C3F1 NIH-07   Magnetic Fields/Magnetic Fields Magnetic Fields/Magnetic Fields Magnetic Fields/Magnetic Fields
1998 Rats: Fischer F344 NIH-07   Magnetic Fields/Magnetic Fields Magnetic Fields/Magnetic Fields Magnetic Fields/Magnetic Fields

NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.