National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/datasearch

Databases, Searches & Other Resources




Atlases

Atlas of Mouse Liver Lesions
The Atlas provides digitized images of mouse liver lesions. Pathologists and others can view the images to familiarize themselves with the spontaneous and chemically induced lesions seen in the livers of B6C3F1 mice.

Nonneoplastic Lesion Atlas

The Nonneoplastic Lesion Atlas is a database for non-neoplastic lesions that are organized by organ system and employs a set of guidelines developed for consistent terminology.

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Archives

NTP Archives

Established in 1984, the NTP Archives is a state-of-the-art facility that houses an unmatched collection of research specimens and supporting data from over 2,000 NTP studies. The facility consists of repositories for storage of histologic slides, paraffin blocks, formalin-fixed “wet” tissues, frozen tissues, and printed, microfiched, and electronic study records. Learn more about the NTP Archives.

Request access to the NTP Archives and use of its archival resources by submitting a request to Dr. Ron Herbert (herbert1@niehs.nih.gov).

 

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Databases and Searches

CEBS Database

The Chemical Effects in Biological Systems (CEBS) database houses data of interest to environmental health scientists. CEBS is a public resource, and has received data from academic, industrial and governmental laboratories. CEBS is designed to display data in the context of biology and study design, and to permit data integration across studies for novel meta-analysis.

Learn more about CEBS.

DrugMatrix and ToxFx Databases

DrugMatrix is one of the largest molecular toxicology reference database and informatics system. DrugMatrix is populated with the comprehensive results of thousands of highly controlled and standardized toxicological experiments in which rats or primary rat hepatocytes were systematically treated with therapeutic, industrial, and environmental chemicals at both non-toxic and toxic doses. Following administration of these compounds in vivo, comprehensive studies of the effects of these compounds were carried out at multiple time points and in multiple target organs.
ToxFx is an automated toxicogenomics analysis application. The ToxFX analytical approach utilizes toxicogenomic signatures, specially-curated biochemical pathways and other relevant data to interpret toxicity-related transcriptomic data in minutes and presents the results as a detailed, customized report. This report is intended to improve your understanding of compound toxicity.

Learn more about Drug Matrix and ToxFX.

Historical Control Database


The NTP provides historical control data from its toxicity studies. Tumor incidences and growth and survival curves for control animals from the NTP's two-year carcinogenesis studies are summarized by species, sex, route of administration, and vehicle. The historical controls for the genetically modified models are also separated.

NICEATM LLNA Database

On behalf of ICCVAM, NICEATM has conducted a number of analyses to evaluate the usefulness of the murine local lymph node assay (LLNA) to identify potential skin sensitizers. NICEATM is making this data available for reference to interested stakeholders for developing and evaluating alternative methods that replace, reduce, or refine the use of animals for skin sensitization testing.
Download the NICEATM LLNA database in an Excel spreadsheet.
Users of this data should note:
  • The spreadsheet has three sheets: (1) data, (2) references, and (3) abbreviations.
  • The database includes data published through 2010.
  • These data have been extracted from published and unpublished data sources with permission. Users of this database should consult the original data source for questions regarding data quality and/or authenticity.

NTP Study Databases

The NTP makes available data from their studies including two-year toxicology and carcinogenesis studies, shorter duration Toxicity studies, and in vitro and in vivo Genetic toxicity studies.
You can also download NTP Study data.

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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.