TDMS Study 05114-01 Pathology Tables
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
Facility: Battelle Northwest
Chemical CAS #: 77-47-4
Lock Date: 01/09/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 6| 7| 4| 4| 7| 7| 7| 7| 7| 4| 7| 4| 6| 4| 5| 4| 6| 6| 4|
DAY ON TEST | 3| 8| 3| 3| 3| 8| 5| 3| 5| 5| 3| 0| 3| 3| 2| 5| 3| 5| 6| 5| 0| 5| 7| 2| 5|
| 3| 1| 3| 3| 3| 0| 3| 3| 9| 9| 3| 3| 3| 3| 6| 9| 3| 9| 0| 9| 2| 9| 7| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2|
| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Basophilic Focus | X X X X X X|
Clear Cell Focus | X X |
Granuloma, Multifocal | 2 1|
Hepatodiaphragmatic Nodule | X X X X X |
Pigmentation, Hemosiderin | |
Vacuolization Cytoplasmic | 2 3 4 2 |
Biliary Tract, Cyst | |
Biliary Tract, Hyperplasia | 3 |
Hepatocyte, Hyperplasia | 4 4 |
__________________________________________________________________________|
Mesentery | + + + + |
Hemorrhage | |
Thrombosis | |
Fat, Mineralization | |
Fat, Necrosis | 4 4 2 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 2 3 1 2 3 3 |
__________________________________________________________________________|
Pharynx | + |
Hyperkeratosis | |
Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 4 |
Hyperkeratosis | 3 2 |
Inflammation, Suppurative | 3 3 |
Ulcer | 4 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Inflammation, Suppurative | 3 3 |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 |
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 6| 7| 4| 4| 7| 7| 7| 7| 7| 4| 7| 4| 6| 4| 5| 4| 6| 6| 4|
DAY ON TEST | 3| 8| 3| 3| 3| 8| 5| 3| 5| 5| 3| 0| 3| 3| 2| 5| 3| 5| 6| 5| 0| 5| 7| 2| 5|
| 3| 1| 3| 3| 3| 0| 3| 3| 9| 9| 3| 3| 3| 3| 6| 9| 3| 9| 0| 9| 2| 9| 7| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2|
| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytomegaly | 2 4 3 |
Necrosis | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + + + + + + + + M + + + M + M +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X |
Pars Distalis, Hyperplasia | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 1 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Hyperplasia | 3 |
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Bronchial | + + + M + + + M M M + + M + + M M + + M + M + + M|
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + + + + + + M + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 4 |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + M + + + + +|
Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hyperplasia, Reticulum Cell | 3 |
Necrosis | 4 |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + M +|
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 6| 7| 4| 4| 7| 7| 7| 7| 7| 4| 7| 4| 6| 4| 5| 4| 6| 6| 4|
DAY ON TEST | 3| 8| 3| 3| 3| 8| 5| 3| 5| 5| 3| 0| 3| 3| 2| 5| 3| 5| 6| 5| 0| 5| 7| 2| 5|
| 3| 1| 3| 3| 3| 0| 3| 3| 9| 9| 3| 3| 3| 3| 6| 9| 3| 9| 0| 9| 2| 9| 7| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2|
| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X X |
Hemorrhage | 1 3 |
Hydrocephalus | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 2|
Hyperplasia | 2 |
Inflammation, Chronic | 2 2 |
Inflammation, Suppurative | 3 3|
Metaplasia, Squamous | 1 1 1 1 1 2 1 2|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Granuloma | 3 |
Alveolar Epithelium, Hyperplasia | 2 4 |
Alveolus, Hemorrhage | 1 1 1 1 1 1 1|
Alveolus, Infiltration Cellular, | |
Multifocal, Histiocyte | 1 1 |
Alveolus, Inflammation, Suppurative | |
Artery, Mineralization | 1 |
Peribronchiolar, Pigmentation | 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 2 |
Hemorrhage | 2 1 |
Inflammation, Suppurative | 2 |
Nasolacrimal Duct, Hemorrhage | 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 |
Respiratory Epithelium, Hyperplasia | 1 |
Respiratory Epithelium, Metaplasia, | |
Squamous | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 6| 7| 4| 4| 7| 7| 7| 7| 7| 4| 7| 4| 6| 4| 5| 4| 6| 6| 4|
DAY ON TEST | 3| 8| 3| 3| 3| 8| 5| 3| 5| 5| 3| 0| 3| 3| 2| 5| 3| 5| 6| 5| 0| 5| 7| 2| 5|
| 3| 1| 3| 3| 3| 0| 3| 3| 9| 9| 3| 3| 3| 3| 6| 9| 3| 9| 0| 9| 2| 9| 7| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2|
| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Eye | + + + + |
Cataract | 2 2 2 |
Anterior Chamber, Inflammation, | |
Suppurative | 4 |
Cornea, Inflammation | 4 |
__________________________________________________________________________|
Harderian Gland | + |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 2 2 2 |
Nephropathy, Chronic | 3 2 2 2 2 4 1 3 2 2 2 2 3 2 2 2 1 1 3 1 2 1 2 2 1|
Pelvis, Transitional Epithelium, | |
Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 6| 3| 7| 6| 6| 7| 7| 4| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 8| 3| 3| 3| 3| 3| 3| 0| 8| 3| 3| 3| 7| 3| 8| 8| 3| 3| 5| 0| 5| 3| 3| 3| 3|
| 8| 3| 3| 3| 3| 3| 9| 5| 6| 3| 3| 9| 6| 3| 1| 3| 3| 3| 9| 9| 9| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8|
| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X X |
Clear Cell Focus | |
Granuloma, Multifocal | 1 1 2 1 2 |
Hepatodiaphragmatic Nodule | X X X |
Pigmentation, Hemosiderin | |
Vacuolization Cytoplasmic | 1 3 |
Biliary Tract, Cyst | |
Biliary Tract, Hyperplasia | |
Hepatocyte, Hyperplasia | |
__________________________________________________________________________|
Mesentery | + + + + |
Hemorrhage | |
Thrombosis | X |
Fat, Mineralization | 3 |
Fat, Necrosis | 1 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 1 2 2 2 |
__________________________________________________________________________|
Pharynx | + + |
Hyperkeratosis | 3 |
Hyperplasia | 3 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + I + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 1 |
Hyperkeratosis | 2 |
Inflammation, Suppurative | 1 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + I + + + + + + + + + + + + + + + + + + +|
Erosion | |
Inflammation, Suppurative | 1 |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 |
Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 6| 3| 7| 6| 6| 7| 7| 4| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 8| 3| 3| 3| 3| 3| 3| 0| 8| 3| 3| 3| 7| 3| 8| 8| 3| 3| 5| 0| 5| 3| 3| 3| 3|
| 8| 3| 3| 3| 3| 3| 9| 5| 6| 3| 3| 9| 6| 3| 1| 3| 3| 3| 9| 9| 9| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8|
| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytomegaly | 2 1 3 2 |
Necrosis | 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + M + + + + + + M + + M + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + M M + + + + + + + + + + + + M + M +|
Hyperplasia | 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Pars Distalis, Hyperplasia | 1 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 3 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | 3 3 |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + M + M + + + + + + + + M + M + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
Inflammation, Chronic | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + M + + + + + + + M|
Hemorrhage | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 2 4 3 |
Hyperplasia, Reticulum Cell | 3 2 3 |
Necrosis | |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Thymus | + M + + + + + + + + + + + + + + + + + + + + + + M|
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 6| 3| 7| 6| 6| 7| 7| 4| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 8| 3| 3| 3| 3| 3| 3| 0| 8| 3| 3| 3| 7| 3| 8| 8| 3| 3| 5| 0| 5| 3| 3| 3| 3|
| 8| 3| 3| 3| 3| 3| 9| 5| 6| 3| 3| 9| 6| 3| 1| 3| 3| 3| 9| 9| 9| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8|
| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X |
Hemorrhage | 2 |
Hydrocephalus | 3 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Hyperplasia | |
Inflammation, Chronic | 1 |
Inflammation, Suppurative | 1 1 1 |
Metaplasia, Squamous | 1 1 1|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Granuloma | 2 1 |
Alveolar Epithelium, Hyperplasia | |
Alveolus, Hemorrhage | 1 1 1 2 3 1 1 1 1 |
Alveolus, Infiltration Cellular, | |
Multifocal, Histiocyte | 1 1 |
Alveolus, Inflammation, Suppurative | |
Artery, Mineralization | |
Peribronchiolar, Pigmentation | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 3|
Hemorrhage | 2 |
Inflammation, Suppurative | 3 2 2|
Nasolacrimal Duct, Hemorrhage | |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 |
Respiratory Epithelium, Hyperplasia | 1 2 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 6| 3| 7| 6| 6| 7| 7| 4| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 8| 3| 3| 3| 3| 3| 3| 0| 8| 3| 3| 3| 7| 3| 8| 8| 3| 3| 5| 0| 5| 3| 3| 3| 3|
| 8| 3| 3| 3| 3| 3| 9| 5| 6| 3| 3| 9| 6| 3| 1| 3| 3| 3| 9| 9| 9| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8|
| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Eye | |
Cataract | |
Anterior Chamber, Inflammation, | |
Suppurative | |
Cornea, Inflammation | |
__________________________________________________________________________|
Harderian Gland | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 2 2 2 2 |
Nephropathy, Chronic | 1 1 2 1 3 2 1 2 2 3 3 1 3 4 3 1 1 2 3 2 1 2 3 2|
Pelvis, Transitional Epithelium, | |
Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 6| 7| 7| 3| 7| 6| | |
DAY ON TEST | 5| 3| 3| 3| 4| 1| 3| 7| 3| 6| | |
| 9| 3| 3| 3| 0| 9| 3| 6| 3| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| | A |
CONTROL | 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| | L |
| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | | 1 3.0|
Basophilic Focus | | 10 |
Clear Cell Focus | | 2 |
Granuloma, Multifocal | | 7 1.4|
Hepatodiaphragmatic Nodule | X X | 10 |
Pigmentation, Hemosiderin | 3 | 1 3.0|
Vacuolization Cytoplasmic | 2 | 7 2.4|
Biliary Tract, Cyst | X | 1 |
Biliary Tract, Hyperplasia | | 1 3.0|
Hepatocyte, Hyperplasia | | 2 4.0|
__________________________________________________________________________|____________|
Mesentery | + + | 10 |
Hemorrhage | 4 | 1 4.0|
Thrombosis | | 1 |
Fat, Mineralization | | 1 3.0|
Fat, Necrosis | 1 1 | 9 2.4|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Acinus, Atrophy | 2 2 1 | 15 2.0|
__________________________________________________________________________|____________|
Pharynx | | 3 |
Hyperkeratosis | | 1 3.0|
Hyperplasia | | 2 2.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 59 |
Acanthosis | 1 2 2 | 7 2.1|
Hyperkeratosis | | 3 2.3|
Inflammation, Suppurative | | 3 2.3|
Ulcer | 4 | 3 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 59 |
Erosion | 3 | 1 3.0|
Inflammation, Suppurative | | 3 2.3|
__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 6| 7| 7| 3| 7| 6| | |
DAY ON TEST | 5| 3| 3| 3| 4| 1| 3| 7| 3| 6| | |
| 9| 3| 3| 3| 0| 9| 3| 6| 3| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| | A |
CONTROL | 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| | L |
| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy | | 4 1.5|
Thrombosis | X | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Cytomegaly | 3 | 8 2.5|
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 57 |
Hyperplasia | 2 1 | 3 1.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + + + | 50 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 60 |
Cyst | | 4 |
Pars Distalis, Hyperplasia | 2 | 4 1.8|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
C-Cell, Hyperplasia | 1 1 1 1 | 12 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 59 |
Cyst | X | 2 |
Hyperplasia | 3 | 4 3.0|
Inflammation, Suppurative | 3 | 3 3.3|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 60 |
Cyst | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + + M + + + + + + | 44 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 58 |
Hyperplasia, Lymphoid | 3 | 3 3.0|
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 6| 7| 7| 3| 7| 6| | |
DAY ON TEST | 5| 3| 3| 3| 4| 1| 3| 7| 3| 6| | |
| 9| 3| 3| 3| 0| 9| 3| 6| 3| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| | A |
CONTROL | 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| | L |
| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 59 |
Hemorrhage | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + M + + + + + + | 57 |
Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Fibrosis | | 4 3.0|
Hyperplasia, Reticulum Cell | | 4 2.8|
Necrosis | | 1 4.0|
Pigmentation, Hemosiderin | 4 | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 57 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Compression | X X | 11 |
Hemorrhage | | 3 2.0|
Hydrocephalus | 3 | 4 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 60 |
Foreign Body | 3 | 3 2.3|
Hyperplasia | | 1 2.0|
Inflammation, Chronic | 3 | 4 2.0|
Inflammation, Suppurative | | 5 1.8|
Metaplasia, Squamous | | 11 1.2|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Foreign Body | 4 | 1 4.0|
Granuloma | | 3 2.0|
Alveolar Epithelium, Hyperplasia | 2 | 3 2.7|
Alveolus, Hemorrhage | 1 2 1 | 19 1.2|
Alveolus, Infiltration Cellular, | | |
Multifocal, Histiocyte | 2 | 5 1.2|
Alveolus, Inflammation, Suppurative | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 6| 7| 7| 3| 7| 6| | |
DAY ON TEST | 5| 3| 3| 3| 4| 1| 3| 7| 3| 6| | |
| 9| 3| 3| 3| 0| 9| 3| 6| 3| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| | A |
CONTROL | 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| | L |
| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Artery, Mineralization | | 1 1.0|
Peribronchiolar, Pigmentation | | 3 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Foreign Body | | 3 2.3|
Hemorrhage | 1 | 4 1.5|
Inflammation, Suppurative | 2 | 5 2.2|
Nasolacrimal Duct, Hemorrhage | 2 2 | 3 2.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 2 2.0|
Respiratory Epithelium, Hyperplasia | 1 | 4 1.3|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
Inflammation, Suppurative | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 5 |
Cataract | | 3 2.0|
Anterior Chamber, Inflammation, | | |
Suppurative | | 1 4.0|
Cornea, Inflammation | | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Mineralization | 2 2 2 2 | 13 2.0|
Nephropathy, Chronic | 2 4 3 2 2 3 4 2 | 57 2.1|
Pelvis, Transitional Epithelium, | | |
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
Transitional Epithelium, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
_____________________________________________________________________________________________________________________
| 4| 7| 6| 4| 7| 7| 7| 7| 5| 7| 6| 4| 7| 4| 4| 7| 4| 7| 7| 7| 7| 6| 6| 6| 7|
DAY ON TEST | 5| 3| 9| 5| 3| 3| 3| 3| 2| 3| 8| 5| 3| 5| 5| 3| 5| 3| 3| 3| 3| 8| 5| 5| 3|
| 9| 2| 4| 9| 2| 2| 2| 2| 1| 2| 3| 9| 2| 9| 9| 2| 9| 2| 2| 2| 2| 1| 9| 4| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.01 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2|
| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + |
Mediastinum, Inflammation, | |
Granulomatous | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + |
Angiectasis | 3 |
Basophilic Focus | |
Clear Cell Focus | X X X |
Eosinophilic Focus | |
Granuloma, Multifocal | |
Hepatodiaphragmatic Nodule | X X X X X |
Vacuolization Cytoplasmic | 4 4 |
__________________________________________________________________________|
Mesentery | + + + |
Inflammation, Granulomatous | |
Fat, Necrosis | 4 4 3 |
__________________________________________________________________________|
Pancreas | + + + + + + |
Acinus, Atrophy | 1 |
Artery, Inflammation | |
__________________________________________________________________________|
Salivary Glands | + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + |
Acanthosis | 3 3 4 2 |
Erosion | 4 |
Hyperkeratosis | 2 3 3 |
Inflammation, Suppurative | 3 2 |
Ulcer | 3 |
Muscularis, Hypoplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + |
Erosion | |
Inflammation, Suppurative | 3 2 |
Mineralization | |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + |
Cytomegaly | 4 2 |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
_____________________________________________________________________________________________________________________
| 4| 7| 6| 4| 7| 7| 7| 7| 5| 7| 6| 4| 7| 4| 4| 7| 4| 7| 7| 7| 7| 6| 6| 6| 7|
DAY ON TEST | 5| 3| 9| 5| 3| 3| 3| 3| 2| 3| 8| 5| 3| 5| 5| 3| 5| 3| 3| 3| 3| 8| 5| 5| 3|
| 9| 2| 4| 9| 2| 2| 2| 2| 1| 2| 3| 9| 2| 9| 9| 2| 9| 2| 2| 2| 2| 1| 9| 4| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.01 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2|
| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Necrosis | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + |
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + |
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + |
Cyst | X X X X X |
Pars Distalis, Hyperplasia | 4 3 |
Pars Intermedia, Hyperplasia | 4 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + |
Ultimobranchial Cyst | X |
C-Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + M + + |
Cyst | X X X |
Hyperplasia | 3 |
Inflammation, Suppurative | 4 3 |
__________________________________________________________________________|
Ovary | + + + + + + + |
Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + |
Endometrium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + |
Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | |
Renal, Hyperplasia, Lymphoid | |
Renal, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + |
Hemorrhage | 2 |
__________________________________________________________________________|
Spleen | + + + + + + |
Ectopic Tissue | X |
Fibrosis | |
__________________________________________________________________________|
Thymus | + + + + + + |
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
_____________________________________________________________________________________________________________________
| 4| 7| 6| 4| 7| 7| 7| 7| 5| 7| 6| 4| 7| 4| 4| 7| 4| 7| 7| 7| 7| 6| 6| 6| 7|
DAY ON TEST | 5| 3| 9| 5| 3| 3| 3| 3| 2| 3| 8| 5| 3| 5| 5| 3| 5| 3| 3| 3| 3| 8| 5| 5| 3|
| 9| 2| 4| 9| 2| 2| 2| 2| 1| 2| 3| 9| 2| 9| 9| 2| 9| 2| 2| 2| 2| 1| 9| 4| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.01 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2|
| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + |
Compression | X X X |
Hemorrhage | |
Hydrocephalus | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + M + + + + + + + + + +|
Foreign Body | 2 |
Inflammation, Chronic | |
Inflammation, Suppurative | |
Metaplasia, Squamous | 1 1 1 1 1 2 1 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | |
Alveolus, Hemorrhage | 1 1 1 1 1 1 1 1 1 1 |
Alveolus, Infiltration Cellular, | |
Multifocal, Histiocyte | 1 2 2 |
Artery, Mineralization | 1 |
Bronchiole, Pigmentation | 1 1 1 1 1 1 1 1|
Peribronchiolar, Pigmentation | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Hemorrhage | 2 |
Inflammation, Suppurative | 4 1|
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 2 2 |
Respiratory Epithelium, Hyperplasia | 2 1|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 2 |
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
_____________________________________________________________________________________________________________________
| 4| 7| 6| 4| 7| 7| 7| 7| 5| 7| 6| 4| 7| 4| 4| 7| 4| 7| 7| 7| 7| 6| 6| 6| 7|
DAY ON TEST | 5| 3| 9| 5| 3| 3| 3| 3| 2| 3| 8| 5| 3| 5| 5| 3| 5| 3| 3| 3| 3| 8| 5| 5| 3|
| 9| 2| 4| 9| 2| 2| 2| 2| 1| 2| 3| 9| 2| 9| 9| 2| 9| 2| 2| 2| 2| 1| 9| 4| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.01 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2|
| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 2 2 2 2 |
Nephropathy, Chronic | 2 3 3 1 3 3 3 2 2 4 3 2 2 1 2 3 1 3 3 3 4 3 2 1 3|
__________________________________________________________________________|
Urinary Bladder | + + + + + + |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
_____________________________________________________________________________________________________________________
| 6| 6| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 5| 7| 7| 7| 4| 7| 7| 6| 7| 7|
DAY ON TEST | 6| 5| 0| 5| 3| 3| 3| 3| 3| 3| 3| 3| 5| 0| 3| 6| 3| 3| 3| 5| 3| 3| 2| 3| 3|
| 8| 4| 5| 9| 2| 2| 8| 2| 2| 2| 2| 2| 9| 9| 2| 5| 2| 2| 2| 9| 2| 2| 1| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.01 PPM | 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8|
| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + |
Mediastinum, Inflammation, | |
Granulomatous | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + |
Angiectasis | |
Basophilic Focus | X X |
Clear Cell Focus | X |
Eosinophilic Focus | X |
Granuloma, Multifocal | 2 |
Hepatodiaphragmatic Nodule | X X X X X |
Vacuolization Cytoplasmic | 3 3 |
__________________________________________________________________________|
Mesentery | + |
Inflammation, Granulomatous | 3 |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + |
Acinus, Atrophy | |
Artery, Inflammation | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + |
Acanthosis | 3 4 |
Erosion | 4 |
Hyperkeratosis | 3 |
Inflammation, Suppurative | |
Ulcer | 4 |
Muscularis, Hypoplasia | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + |
Erosion | 4 |
Inflammation, Suppurative | |
Mineralization | 4 |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + |
Cytomegaly | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
_____________________________________________________________________________________________________________________
| 6| 6| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 5| 7| 7| 7| 4| 7| 7| 6| 7| 7|
DAY ON TEST | 6| 5| 0| 5| 3| 3| 3| 3| 3| 3| 3| 3| 5| 0| 3| 6| 3| 3| 3| 5| 3| 3| 2| 3| 3|
| 8| 4| 5| 9| 2| 2| 8| 2| 2| 2| 2| 2| 9| 9| 2| 5| 2| 2| 2| 9| 2| 2| 1| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.01 PPM | 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8|
| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Necrosis | 4 |
__________________________________________________________________________|
Adrenal Medulla | + + + + M + + + + |
Hyperplasia | 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + |
Hyperplasia | 2 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + |
Cyst | X X X X |
Pars Distalis, Hyperplasia | 2 3 4 |
Pars Intermedia, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + |
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + |
Cyst | |
Hyperplasia | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Ovary | + + + + + + + |
Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + |
Endometrium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + |
Renal, Hyperplasia, Lymphoid | 4 |
Renal, Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + |
Hemorrhage | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + |
Ectopic Tissue | |
Fibrosis | 4 |
__________________________________________________________________________|
Thymus | + + + + + + + |
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
_____________________________________________________________________________________________________________________
| 6| 6| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 5| 7| 7| 7| 4| 7| 7| 6| 7| 7|
DAY ON TEST | 6| 5| 0| 5| 3| 3| 3| 3| 3| 3| 3| 3| 5| 0| 3| 6| 3| 3| 3| 5| 3| 3| 2| 3| 3|
| 8| 4| 5| 9| 2| 2| 8| 2| 2| 2| 2| 2| 9| 9| 2| 5| 2| 2| 2| 9| 2| 2| 1| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.01 PPM | 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8|
| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + |
Compression | X |
Hemorrhage | 1 3 |
Hydrocephalus | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Inflammation, Chronic | 2 |
Inflammation, Suppurative | 2 |
Metaplasia, Squamous | 1 1 3 1 1 1 1 1 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | 3 2 1 |
Alveolus, Hemorrhage | 1 1 2 2 1 1 1 |
Alveolus, Infiltration Cellular, | |
Multifocal, Histiocyte | 2 1 |
Artery, Mineralization | 1 |
Bronchiole, Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Peribronchiolar, Pigmentation | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 4 |
Hemorrhage | |
Inflammation, Suppurative | 3 2 4 |
Pigmentation | 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1|
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 2 2 2 2 |
Respiratory Epithelium, Hyperplasia | 4 2 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cataract | |
__________________________________________________________________________|
Harderian Gland | |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
_____________________________________________________________________________________________________________________
| 6| 6| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 5| 7| 7| 7| 4| 7| 7| 6| 7| 7|
DAY ON TEST | 6| 5| 0| 5| 3| 3| 3| 3| 3| 3| 3| 3| 5| 0| 3| 6| 3| 3| 3| 5| 3| 3| 2| 3| 3|
| 8| 4| 5| 9| 2| 2| 8| 2| 2| 2| 2| 2| 9| 9| 2| 5| 2| 2| 2| 9| 2| 2| 1| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.01 PPM | 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8|
| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 2 2 1 1 |
Nephropathy, Chronic | 2 2 4 2 2 2 1 2 2 2 2 2 1 2 2 2 3 3 3 2 4 4 3 3 4|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 6| 7| 7| 4| 7| | |
DAY ON TEST | 3| 3| 9| 3| 2| 2| 2| 3| 5| 3| | |
| 2| 2| 1| 2| 4| 5| 4| 2| 9| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| | A |
0.01 PPM | 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| | L |
| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + | 18 |
Mediastinum, Inflammation, | | |
Granulomatous | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + | 17 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + | 17 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + | 17 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + | 17 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + | 17 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + | 17 |
__________________________________________________________________________|____________|
Liver | + + + + + + | 34 |
Angiectasis | | 1 3.0|
Basophilic Focus | | 2 |
Clear Cell Focus | | 4 |
Eosinophilic Focus | | 1 |
Granuloma, Multifocal | | 1 2.0|
Hepatodiaphragmatic Nodule | X | 11 |
Vacuolization Cytoplasmic | 2 | 5 3.2|
__________________________________________________________________________|____________|
Mesentery | + + | 6 |
Inflammation, Granulomatous | | 1 3.0|
Fat, Necrosis | 3 3 | 6 3.3|
__________________________________________________________________________|____________|
Pancreas | + + + + | 17 |
Acinus, Atrophy | | 1 1.0|
Artery, Inflammation | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + | 17 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + | 18 |
Acanthosis | 4 4 | 8 3.4|
Erosion | 4 | 3 4.0|
Hyperkeratosis | 4 4 | 6 3.2|
Inflammation, Suppurative | | 2 2.5|
Ulcer | 4 | 3 3.7|
Muscularis, Hypoplasia | | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + | 17 |
Erosion | | 1 4.0|
Inflammation, Suppurative | | 2 2.5|
Mineralization | | 1 4.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + | 17 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 6| 7| 7| 4| 7| | |
DAY ON TEST | 3| 3| 9| 3| 2| 2| 2| 3| 5| 3| | |
| 2| 2| 1| 2| 4| 5| 4| 2| 9| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| | A |
0.01 PPM | 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| | L |
| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + | 21 |
Cytomegaly | 4 3 3 | 5 3.2|
Hemorrhage | 3 | 1 3.0|
Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + | 19 |
Hyperplasia | 3 | 3 2.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + | 18 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + | 17 |
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + | 39 |
Cyst | | 9 |
Pars Distalis, Hyperplasia | 4 | 6 3.3|
Pars Intermedia, Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + | 19 |
Ultimobranchial Cyst | X | 2 |
C-Cell, Hyperplasia | 1 | 3 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + M + + | 22 |
Cyst | | 3 |
Hyperplasia | | 1 3.0|
Inflammation, Suppurative | | 2 3.5|
__________________________________________________________________________|____________|
Ovary | + + + + | 18 |
Cyst | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + | 22 |
Endometrium, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + | 17 |
Myelofibrosis | 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node | + | 2 |
Renal, Hyperplasia, Lymphoid | | 1 4.0|
Renal, Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + | 17 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 6| 7| 7| 4| 7| | |
DAY ON TEST | 3| 3| 9| 3| 2| 2| 2| 3| 5| 3| | |
| 2| 2| 1| 2| 4| 5| 4| 2| 9| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| | A |
0.01 PPM | 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| | L |
| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + | 18 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + | 17 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + | 18 |
Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + | 21 |
Ectopic Tissue | | 1 |
Fibrosis | 3 3 | 3 3.3|
__________________________________________________________________________|____________|
Thymus | + + + + | 17 |
Cyst | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + | 34 |
__________________________________________________________________________|____________|
Skin | + + + + | 17 |
Ulcer | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + | 17 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + | 18 |
Compression | X X | 6 |
Hemorrhage | | 2 2.0|
Hydrocephalus | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 59 |
Foreign Body | | 1 2.0|
Inflammation, Chronic | 1 | 2 1.5|
Inflammation, Suppurative | 2 | 2 2.0|
Metaplasia, Squamous | 1 1 1 1 | 21 1.2|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Alveolar Epithelium, Hyperplasia | | 3 2.0|
Alveolus, Hemorrhage | 1 | 18 1.1|
Alveolus, Infiltration Cellular, | | |
Multifocal, Histiocyte | 2 2 | 7 1.7|
Artery, Mineralization | | 2 1.0|
Bronchiole, Pigmentation | 1 1 1 | 26 1.0|
Peribronchiolar, Pigmentation | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 6| 7| 7| 4| 7| | |
DAY ON TEST | 3| 3| 9| 3| 2| 2| 2| 3| 5| 3| | |
| 2| 2| 1| 2| 4| 5| 4| 2| 9| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| | A |
0.01 PPM | 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| | L |
| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Foreign Body | | 1 4.0|
Hemorrhage | | 1 2.0|
Inflammation, Suppurative | | 5 2.8|
Pigmentation | 1 1 1 1 1 1 1 | 42 1.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 2 | 10 2.0|
Respiratory Epithelium, Hyperplasia | 2 | 6 2.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
Inflammation, Chronic | | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Cataract | | 1 2.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Mineralization | 2 1 2 2 | 14 1.7|
Nephropathy, Chronic | 2 3 4 3 2 4 3 1 4 | 59 2.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + | 17 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
_____________________________________________________________________________________________________________________
| 4| 6| 3| 4| 7| 4| 7| 6| 5| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 5| 7| 4| 7|
DAY ON TEST | 5| 5| 6| 5| 3| 5| 3| 1| 5| 3| 6| 3| 0| 3| 3| 4| 3| 3| 3| 3| 5| 9| 1| 5| 3|
| 9| 2| 7| 9| 1| 9| 1| 1| 0| 1| 9| 1| 9| 1| 1| 2| 1| 1| 1| 1| 9| 0| 8| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.05 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2|
| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + + + A + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + A + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + |
Angiectasis | 3 3 4 |
Basophilic Focus | X X |
Clear Cell Focus | X |
Granuloma, Multifocal | 3 |
Hepatodiaphragmatic Nodule | X X |
Vacuolization Cytoplasmic | |
Hepatocyte, Hyperplasia | 4 |
__________________________________________________________________________|
Mesentery | + + |
Hemorrhage | |
Inflammation, Granulomatous | |
Fat, Necrosis | 4 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + |
Acinus, Atrophy | 1 |
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + +|
Acanthosis | 2 1 2 2 |
Hyperkeratosis | 3 2 2 |
Inflammation, Suppurative | |
Ulcer | 4 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + +|
Inflammation, Suppurative | |
Muscularis, Hypoplasia | 4 |
__________________________________________________________________________|
Tongue | + |
__________________________________________________________________________|
Tooth | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + |
Cardiomyopathy | |
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + |
Cytomegaly | 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
_____________________________________________________________________________________________________________________
| 4| 6| 3| 4| 7| 4| 7| 6| 5| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 5| 7| 4| 7|
DAY ON TEST | 5| 5| 6| 5| 3| 5| 3| 1| 5| 3| 6| 3| 0| 3| 3| 4| 3| 3| 3| 3| 5| 9| 1| 5| 3|
| 9| 2| 7| 9| 1| 9| 1| 1| 0| 1| 9| 1| 9| 1| 1| 2| 1| 1| 1| 1| 9| 0| 8| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.05 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2|
| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | 3 |
Bilateral, Hyperplasia | 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + +|
Cyst | X X|
Hemorrhage | |
Pars Distalis, Hyperplasia | 2 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + |
C-Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + |
Cyst | X |
Hyperplasia | 3 3 3 3 |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + |
Cyst | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Infarct | |
Inflammation, Suppurative | |
Endometrium, Hyperplasia | 2 |
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + |
Hyperplasia, Reticulum Cell | 4 |
__________________________________________________________________________|
Lymph Node | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + M + + + + |
Hemorrhage | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + |
Hyperplasia, Lymphoid | |
Inflammation, Chronic | 3 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + |
Hemorrhage | 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + M + + + + + + + |
Hemorrhage | 1 |
Pigmentation | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + |
Ectopic Tissue | |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
_____________________________________________________________________________________________________________________
| 4| 6| 3| 4| 7| 4| 7| 6| 5| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 5| 7| 4| 7|
DAY ON TEST | 5| 5| 6| 5| 3| 5| 3| 1| 5| 3| 6| 3| 0| 3| 3| 4| 3| 3| 3| 3| 5| 9| 1| 5| 3|
| 9| 2| 7| 9| 1| 9| 1| 1| 0| 1| 9| 1| 9| 1| 1| 2| 1| 1| 1| 1| 9| 0| 8| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.05 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2|
| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Fibrosis | 3 3 |
Hyperplasia, Reticulum Cell | 4 |
Necrosis | 4 3 |
__________________________________________________________________________|
Thymus | + M + + + + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + |
__________________________________________________________________________|
Skin | + + + + + + + + + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + |
Compression | X X X |
Hemorrhage | 2 1 3 4 |
Hydrocephalus | 4 4 |
Necrosis | 4 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + I + + + + + + +|
Foreign Body | 2 2 |
Inflammation, Chronic | 1 1 2 |
Inflammation, Suppurative | 2 |
Metaplasia, Squamous | 1 1 1 1 1 1 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 4 |
Granuloma | |
Alveolar Epithelium, Hyperplasia | 3 |
Alveolus, Hemorrhage | 1 1 1 2 2 1 2 2 1 2 1 1 |
Alveolus, Infiltration Cellular, | |
Multifocal, Histiocyte | 2 1 2 |
Artery, Mineralization | 1 |
Bronchiole, Pigmentation | 1 1 1 1 1 1 1 1 1 1 2 1 1 1 2 1 1 1 1 1 1|
Peribronchiolar, Pigmentation | 1 1 1 |
Pleura, Fibrosis | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 2 3 |
Hemorrhage | 1 2 |
Inflammation, Suppurative | 2 3 |
Pigmentation | 1 1 1 1 2 1 2 1 2 1 2 2 2 2 2 2 2 2 1 1 1 1 2|
Nasolacrimal Duct, Hemorrhage | |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
_____________________________________________________________________________________________________________________
| 4| 6| 3| 4| 7| 4| 7| 6| 5| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 5| 7| 4| 7|
DAY ON TEST | 5| 5| 6| 5| 3| 5| 3| 1| 5| 3| 6| 3| 0| 3| 3| 4| 3| 3| 3| 3| 5| 9| 1| 5| 3|
| 9| 2| 7| 9| 1| 9| 1| 1| 0| 1| 9| 1| 9| 1| 1| 2| 1| 1| 1| 1| 9| 0| 8| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.05 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2|
| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Respiratory Epithelium, Hyperplasia | 1 2 |
Respiratory Epithelium, Metaplasia, | |
Squamous | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + + |
Cataract | 2 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 3 2 2 2 2 1 3 2 |
Nephropathy, Chronic | 2 1 2 2 2 3 2 1 3 2 3 2 2 3 3 2 1 2 2 1 3 4 1 3|
Cortex, Renal Tubule, Cytoplasmic | |
Alteration | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 5| 7| 4| 7| 6| 7| 4| 7| 7| 5| 0| 7| 7| 5| 4| 7| 7| 4| 7| 4| 7|
DAY ON TEST | 9| 3| 3| 3| 8| 3| 5| 3| 9| 3| 0| 3| 3| 9| 3| 3| 3| 6| 5| 3| 3| 5| 3| 5| 3|
| 5| 1| 1| 1| 5| 1| 9| 1| 5| 1| 2| 1| 1| 7| 7| 1| 1| 2| 9| 1| 1| 9| 1| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.05 PPM | 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8|
| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | |
Clear Cell Focus | X X|
Granuloma, Multifocal | 4 |
Hepatodiaphragmatic Nodule | X X X X |
Vacuolization Cytoplasmic | 4 4 |
Hepatocyte, Hyperplasia | 4 |
__________________________________________________________________________|
Mesentery | + + |
Hemorrhage | 4 |
Inflammation, Granulomatous | |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + |
Acinus, Atrophy | 1 |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + M + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + +|
Acanthosis | 3 |
Hyperkeratosis | 3 |
Inflammation, Suppurative | |
Ulcer | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + +|
Inflammation, Suppurative | |
Muscularis, Hypoplasia | |
__________________________________________________________________________|
Tongue | |
__________________________________________________________________________|
Tooth | + |
Inflammation, Suppurative | 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + |
Cardiomyopathy | |
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + |
Cytomegaly | 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 5| 7| 4| 7| 6| 7| 4| 7| 7| 5| 0| 7| 7| 5| 4| 7| 7| 4| 7| 4| 7|
DAY ON TEST | 9| 3| 3| 3| 8| 3| 5| 3| 9| 3| 0| 3| 3| 9| 3| 3| 3| 6| 5| 3| 3| 5| 3| 5| 3|
| 5| 1| 1| 1| 5| 1| 9| 1| 5| 1| 2| 1| 1| 7| 7| 1| 1| 2| 9| 1| 1| 9| 1| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.05 PPM | 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8|
| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | 2 3 |
Bilateral, Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + |
Cyst | X X X X |
Hemorrhage | |
Pars Distalis, Hyperplasia | 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + |
C-Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + M + + |
Cyst | |
Hyperplasia | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Ovary | + + + + + + + + |
Cyst | X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 1 1 |
Infarct | 4 |
Inflammation, Suppurative | 2 |
Endometrium, Hyperplasia | 2 2 |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + |
Hyperplasia, Reticulum Cell | |
__________________________________________________________________________|
Lymph Node | + |
__________________________________________________________________________|
Lymph Node, Bronchial | + M + M + + |
Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + |
Hyperplasia, Lymphoid | 2 |
Inflammation, Chronic | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + |
Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + M + + + + + |
Hemorrhage | |
Pigmentation | |
__________________________________________________________________________|
Spleen | + + + + + + + + |
Ectopic Tissue | X X |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 5| 7| 4| 7| 6| 7| 4| 7| 7| 5| 0| 7| 7| 5| 4| 7| 7| 4| 7| 4| 7|
DAY ON TEST | 9| 3| 3| 3| 8| 3| 5| 3| 9| 3| 0| 3| 3| 9| 3| 3| 3| 6| 5| 3| 3| 5| 3| 5| 3|
| 5| 1| 1| 1| 5| 1| 9| 1| 5| 1| 2| 1| 1| 7| 7| 1| 1| 2| 9| 1| 1| 9| 1| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.05 PPM | 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8|
| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Fibrosis | 4 3 |
Hyperplasia, Reticulum Cell | |
Necrosis | |
__________________________________________________________________________|
Thymus | M M + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + M + + + |
__________________________________________________________________________|
Skin | + + + + + M + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + |
Compression | |
Hemorrhage | 1 |
Hydrocephalus | |
Necrosis | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 |
Inflammation, Chronic | 1 |
Inflammation, Suppurative | 2 |
Metaplasia, Squamous | 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Granuloma | 3 |
Alveolar Epithelium, Hyperplasia | 1 |
Alveolus, Hemorrhage | 1 1 3 1 2 1 |
Alveolus, Infiltration Cellular, | |
Multifocal, Histiocyte | 2 3 3 1 |
Artery, Mineralization | 1 |
Bronchiole, Pigmentation | 1 1 1 1 1 1 1 2 2 1 1 1 1 1 1 1 1 1 1 1 1|
Peribronchiolar, Pigmentation | 1 1 |
Pleura, Fibrosis | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 2 1 |
Hemorrhage | 3 2 2 2|
Inflammation, Suppurative | 3 1 |
Pigmentation | 2 2 2 2 2 2 1 2 1 2 1 2 1 1 2 2 1 1 2 2 1 2 1 2|
Nasolacrimal Duct, Hemorrhage | |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 5| 7| 4| 7| 6| 7| 4| 7| 7| 5| 0| 7| 7| 5| 4| 7| 7| 4| 7| 4| 7|
DAY ON TEST | 9| 3| 3| 3| 8| 3| 5| 3| 9| 3| 0| 3| 3| 9| 3| 3| 3| 6| 5| 3| 3| 5| 3| 5| 3|
| 5| 1| 1| 1| 5| 1| 9| 1| 5| 1| 2| 1| 1| 7| 7| 1| 1| 2| 9| 1| 1| 9| 1| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.05 PPM | 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8|
| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Respiratory Epithelium, Hyperplasia | 3 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 2 2 2 |
Nephropathy, Chronic | 1 3 2 2 2 2 1 3 2 3 1 3 3 2 2 4 2 1 3 3 1 2 1 2|
Cortex, Renal Tubule, Cytoplasmic | |
Alteration | 4 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 4| 3| 6| 5| 7| | |
DAY ON TEST | 4| 3| 3| 3| 3| 5| 6| 1| 6| 3| | |
| 9| 1| 1| 1| 1| 9| 6| 8| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| | A |
0.05 PPM | 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| | L |
| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + | 19 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + A | 18 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + A | 18 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + A A | 15 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + A | 18 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A A | 16 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A A | 16 |
__________________________________________________________________________|____________|
Liver | + + + + + + | 32 |
Angiectasis | 2 | 4 3.0|
Basophilic Focus | | 2 |
Clear Cell Focus | | 3 |
Granuloma, Multifocal | | 2 3.5|
Hepatodiaphragmatic Nodule | X X | 8 |
Vacuolization Cytoplasmic | 4 4 | 4 4.0|
Hepatocyte, Hyperplasia | | 2 4.0|
__________________________________________________________________________|____________|
Mesentery | + + | 6 |
Hemorrhage | 4 | 2 4.0|
Inflammation, Granulomatous | 4 3 | 2 3.5|
Fat, Necrosis | 3 3 | 5 3.2|
__________________________________________________________________________|____________|
Pancreas | + + + + | 19 |
Acinus, Atrophy | 1 | 3 1.0|
__________________________________________________________________________|____________|
Pharynx | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + | 18 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + | 22 |
Acanthosis | 3 2 | 7 2.1|
Hyperkeratosis | 3 2 | 6 2.5|
Inflammation, Suppurative | 2 | 1 2.0|
Ulcer | | 3 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + | 23 |
Inflammation, Suppurative | 2 | 1 2.0|
Muscularis, Hypoplasia | 3 | 2 3.5|
__________________________________________________________________________|____________|
Tongue | | 1 |
__________________________________________________________________________|____________|
Tooth | | 1 |
Inflammation, Suppurative | | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + | 19 |
Cardiomyopathy | 1 | 1 1.0|
Thrombosis | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 4| 3| 6| 5| 7| | |
DAY ON TEST | 4| 3| 3| 3| 3| 5| 6| 1| 6| 3| | |
| 9| 1| 1| 1| 1| 9| 6| 8| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| | A |
0.05 PPM | 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| | L |
| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + | 19 |
Cytomegaly | | 2 3.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + | 20 |
Hyperplasia | 3 | 4 2.8|
Bilateral, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + | 19 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + | 19 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + | 38 |
Cyst | X X | 8 |
Hemorrhage | 4 | 1 4.0|
Pars Distalis, Hyperplasia | | 4 2.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + | 19 |
C-Cell, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + | 27 |
Cyst | X X | 3 |
Hyperplasia | 3 3 | 6 3.0|
Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Ovary | + + + + + | 24 |
Cyst | | 5 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 59 |
Dilatation | | 2 1.0|
Infarct | | 1 4.0|
Inflammation, Suppurative | | 1 2.0|
Endometrium, Hyperplasia | | 3 2.0|
__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + | 19 |
Hyperplasia, Reticulum Cell | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + | 16 |
Hemorrhage | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 4| 3| 6| 5| 7| | |
DAY ON TEST | 4| 3| 3| 3| 3| 5| 6| 1| 6| 3| | |
| 9| 1| 1| 1| 1| 9| 6| 8| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| | A |
0.05 PPM | 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| | L |
| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + | 18 |
Hyperplasia, Lymphoid | | 1 2.0|
Inflammation, Chronic | | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + | 18 |
Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + | 18 |
Hemorrhage | | 1 1.0|
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + | 26 |
Ectopic Tissue | | 2 |
Fibrosis | 3 | 5 3.2|
Hyperplasia, Reticulum Cell | | 1 4.0|
Necrosis | | 2 3.5|
__________________________________________________________________________|____________|
Thymus | + + + + | 16 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + | 29 |
__________________________________________________________________________|____________|
Skin | + + + + | 19 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + | 19 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + | 19 |
Compression | X | 4 |
Hemorrhage | 3 1 2 | 8 2.1|
Hydrocephalus | 3 | 3 3.7|
Necrosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 58 |
Foreign Body | | 3 2.0|
Inflammation, Chronic | | 4 1.3|
Inflammation, Suppurative | | 2 2.0|
Metaplasia, Squamous | 1 | 15 1.1|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 59 |
Congestion | | 1 4.0|
Granuloma | | 1 3.0|
Alveolar Epithelium, Hyperplasia | | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 4| 3| 6| 5| 7| | |
DAY ON TEST | 4| 3| 3| 3| 3| 5| 6| 1| 6| 3| | |
| 9| 1| 1| 1| 1| 9| 6| 8| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| | A |
0.05 PPM | 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| | L |
| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolus, Hemorrhage | 2 1 1 3 | 22 1.5|
Alveolus, Infiltration Cellular, | | |
Multifocal, Histiocyte | 3 | 8 2.1|
Artery, Mineralization | | 2 1.0|
Bronchiole, Pigmentation | 1 1 1 1 1 1 | 48 1.1|
Peribronchiolar, Pigmentation | | 5 1.0|
Pleura, Fibrosis | 3 1 | 2 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 59 |
Foreign Body | | 6 2.0|
Hemorrhage | | 6 2.0|
Inflammation, Suppurative | | 4 2.3|
Pigmentation | 1 2 1 1 2 1 2 1 1 2 | 57 1.5|
Nasolacrimal Duct, Hemorrhage | 2 | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 | 9 2.0|
Respiratory Epithelium, Hyperplasia | 1 | 4 1.8|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 2 1.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 59 |
Inflammation, Chronic | | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 6 |
Cataract | | 2 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 59 |
Mineralization | 2 | 13 2.1|
Nephropathy, Chronic | 1 2 3 4 3 1 3 1 2 | 57 2.2|
Cortex, Renal Tubule, Cytoplasmic | | |
Alteration | | 1 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + | 19 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 4| 7| 4| 7| 6| 6| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 6| 3| 5| 1| 5| 2| 3| 5| 2| 1|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 5| 0| 0| 0| 8| 0| 9| 0| 9| 4| 5| 8| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.2_PPM | 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2|
| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 |
Basophilic Focus | X |
Clear Cell Focus | X X |
Granuloma, Multifocal | 2 |
Hepatodiaphragmatic Nodule | X X X X X |
Vacuolization Cytoplasmic | 4|
__________________________________________________________________________|
Mesentery | + |
Hemorrhage | |
Fat, Necrosis | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Acinus, Atrophy | 1 1 2 1 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 4 3 2 3 2 2|
Erosion | 4 2 3 |
Hyperkeratosis | 3 2|
Inflammation, Suppurative | 2 2|
Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Inflammation, Suppurative | 2 2|
__________________________________________________________________________|
Tooth | + |
Inflammation, Suppurative | 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytomegaly | 1 2 2 2 3 2 |
Hemorrhage | 2 |
Hyperplasia | 4 |
Necrosis | 3 |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 4| 7| 4| 7| 6| 6| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 6| 3| 5| 1| 5| 2| 3| 5| 2| 1|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 5| 0| 0| 0| 8| 0| 9| 0| 9| 4| 5| 8| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.2_PPM | 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2|
| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
Bilateral, Hyperplasia | 2 3 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + M + M + M + + + + + M + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | X X |
C-Cell, Hyperplasia | 1 3 2 1 3 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Hyperplasia | |
Inflammation, Suppurative | 3 4 |
__________________________________________________________________________|
Ovary | + + + + + + + + M + + + + + + + + + + + + + + + +|
Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cervix, Muscularis, Hyperplasia | 3 |
Endometrium, Hyperplasia | 4 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + |
Renal, Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | M + + + + + + + + + + + + + + + + M + M + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + M + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | M + M + + + M + + + + + + + + + + + + + + + + + +|
Pigmentation | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Tissue | X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + M + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 4| 7| 4| 7| 6| 6| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 6| 3| 5| 1| 5| 2| 3| 5| 2| 1|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 5| 0| 0| 0| 8| 0| 9| 0| 9| 4| 5| 8| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.2_PPM | 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2|
| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Inflammation, Suppurative | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Ulcer | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X X X X X|
Hemorrhage | 3 2|
Hydrocephalus | 3 3 3 3 2 2 3|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Inflammation, Suppurative | 2 1 |
Metaplasia, Squamous | 1 1 1 1 1 1 1 1 1 1 2 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Foreign Body | |
Alveolar Epithelium, Hyperplasia | 2 2 2 1 2 |
Alveolus, Hemorrhage | 2 1 1 1 2 1 1 1 3 1 |
Alveolus, Infiltration Cellular, | |
Multifocal, Histiocyte | 2 2 2 3 |
Alveolus, Inflammation, Suppurative | 1 |
Artery, Mineralization | |
Bronchiole, Pigmentation | 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 1 2 1 2 2 2 2 1|
Peribronchiolar, Pigmentation | 1 1 1 1 1 1 1 1 1 2 1 1 1 1|
Pleura, Fibrosis | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 2 2 1 |
Hemorrhage | 3 |
Inflammation, Suppurative | 2 3 1 |
Pigmentation | 2 2 2 2 2 2 2 2 2 2 2 3 2 2 1 2 2 1 2 2 2 1 1 1|
Nasolacrimal Duct, Hemorrhage | 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | |
Respiratory Epithelium, Hyperplasia | 1 2 |
Respiratory Epithelium, Metaplasia, | |
Squamous | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 4| 7| 4| 7| 6| 6| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 6| 3| 5| 1| 5| 2| 3| 5| 2| 1|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 5| 0| 0| 0| 8| 0| 9| 0| 9| 4| 5| 8| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.2_PPM | 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2|
| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Pigmentation | 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 2 2 2 2 2 2|
Nephropathy, Chronic | 2 4 1 2 4 3 2 3 4 2 3 3 3 3 1 1 2 2 4 2 2 3 3 2 3|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + M + + + + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
_____________________________________________________________________________________________________________________
| 7| 4| 5| 7| 6| 7| 4| 4| 6| 4| 7| 7| 7| 4| 6| 5| 4| 7| 7| 7| 6| 7| 5| 7| 7|
DAY ON TEST | 3| 5| 6| 3| 2| 3| 5| 5| 9| 5| 1| 3| 3| 5| 6| 4| 5| 3| 3| 2| 6| 3| 2| 3| 3|
| 0| 9| 9| 0| 6| 0| 9| 9| 6| 9| 0| 0| 0| 9| 7| 1| 9| 0| 0| 6| 7| 0| 8| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.2_PPM | 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8|
| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Basophilic Focus | X X |
Clear Cell Focus | X|
Granuloma, Multifocal | 2 1 2 |
Hepatodiaphragmatic Nodule | X X X X X|
Vacuolization Cytoplasmic | 2 3 |
__________________________________________________________________________|
Mesentery | + |
Hemorrhage | |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Acinus, Atrophy | 2 2 2 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 |
Erosion | |
Hyperkeratosis | 2 |
Inflammation, Suppurative | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Tooth | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytomegaly | |
Hemorrhage | |
Hyperplasia | 2 2 |
Necrosis | |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
_____________________________________________________________________________________________________________________
| 7| 4| 5| 7| 6| 7| 4| 4| 6| 4| 7| 7| 7| 4| 6| 5| 4| 7| 7| 7| 6| 7| 5| 7| 7|
DAY ON TEST | 3| 5| 6| 3| 2| 3| 5| 5| 9| 5| 1| 3| 3| 5| 6| 4| 5| 3| 3| 2| 6| 3| 2| 3| 3|
| 0| 9| 9| 0| 6| 0| 9| 9| 6| 9| 0| 0| 0| 9| 7| 1| 9| 0| 0| 6| 7| 0| 8| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.2_PPM | 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8|
| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + M + + + + + + + +|
Hyperplasia | 2 |
Bilateral, Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + M + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + M + + + + M + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Pars Distalis, Hyperplasia | 2 3 3 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 1 1 4 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cervix, Muscularis, Hyperplasia | 3 |
Endometrium, Hyperplasia | 2 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | |
Renal, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + M M + + + M + M + + M + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + M + + + + + + + + + + + + + + + + + + + +|
Pigmentation | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Tissue | X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + M + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
_____________________________________________________________________________________________________________________
| 7| 4| 5| 7| 6| 7| 4| 4| 6| 4| 7| 7| 7| 4| 6| 5| 4| 7| 7| 7| 6| 7| 5| 7| 7|
DAY ON TEST | 3| 5| 6| 3| 2| 3| 5| 5| 9| 5| 1| 3| 3| 5| 6| 4| 5| 3| 3| 2| 6| 3| 2| 3| 3|
| 0| 9| 9| 0| 6| 0| 9| 9| 6| 9| 0| 0| 0| 9| 7| 1| 9| 0| 0| 6| 7| 0| 8| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.2_PPM | 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8|
| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X X |
Hemorrhage | 2 |
Hydrocephalus | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 2 4 1 |
Inflammation, Suppurative | |
Metaplasia, Squamous | 1 1 2 2 2 2 2|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 4 |
Foreign Body | 4 |
Alveolar Epithelium, Hyperplasia | 2 2 |
Alveolus, Hemorrhage | 1 1 2 2 1 2 1 1 2 2 |
Alveolus, Infiltration Cellular, | |
Multifocal, Histiocyte | 2 2 2 2 2 |
Alveolus, Inflammation, Suppurative | 1 4 |
Artery, Mineralization | 1 |
Bronchiole, Pigmentation | 2 2 1 1 2 1 2 1 1 1 1 2 2 2 2 1 1 2 2 2 1 2 1 2 2|
Peribronchiolar, Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1|
Pleura, Fibrosis | 2|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 2 |
Hemorrhage | |
Inflammation, Suppurative | 1 2 3 3 3 3 2 1 |
Pigmentation | 2 1 2 2 1 1 1 2 2 1 1 1 2 1 1 2 1 1 2 1 1 2 1 2 2|
Nasolacrimal Duct, Hemorrhage | 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 2 |
Respiratory Epithelium, Hyperplasia | 2 1 1 2 2 2 2 2 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
_____________________________________________________________________________________________________________________
| 7| 4| 5| 7| 6| 7| 4| 4| 6| 4| 7| 7| 7| 4| 6| 5| 4| 7| 7| 7| 6| 7| 5| 7| 7|
DAY ON TEST | 3| 5| 6| 3| 2| 3| 5| 5| 9| 5| 1| 3| 3| 5| 6| 4| 5| 3| 3| 2| 6| 3| 2| 3| 3|
| 0| 9| 9| 0| 6| 0| 9| 9| 6| 9| 0| 0| 0| 9| 7| 1| 9| 0| 0| 6| 7| 0| 8| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.2_PPM | 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8|
| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Pigmentation | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Cataract | 2 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 2 2 2 2 |
Nephropathy, Chronic | 3 2 2 3 2 3 1 2 3 2 1 3 3 2 4 3 1 3 2 3 1 3 2 1 3|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 6| 7| 5| 7| 7| 5| 4| | |
DAY ON TEST | 5| 3| 3| 2| 3| 8| 3| 3| 9| 5| | |
| 9| 0| 0| 8| 0| 8| 0| 0| 7| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| | A |
0.2_PPM | 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| | L |
| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + A + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + A + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + A + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + A + | 57 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | | 2 3.5|
Basophilic Focus | | 3 |
Clear Cell Focus | | 3 |
Granuloma, Multifocal | 2 2 | 6 1.8|
Hepatodiaphragmatic Nodule | X X | 12 |
Vacuolization Cytoplasmic | | 3 3.0|
__________________________________________________________________________|____________|
Mesentery | + | 3 |
Hemorrhage | 4 | 1 4.0|
Fat, Necrosis | | 2 3.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Fibrosis | | 1 2.0|
Acinus, Atrophy | | 9 1.7|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Acanthosis | 3 | 8 2.6|
Erosion | | 3 3.0|
Hyperkeratosis | 3 | 4 2.5|
Inflammation, Suppurative | | 2 2.0|
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Erosion | 4 | 2 3.0|
Inflammation, Suppurative | | 2 2.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
Inflammation, Suppurative | | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy | | 4 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 6| 7| 5| 7| 7| 5| 4| | |
DAY ON TEST | 5| 3| 3| 2| 3| 8| 3| 3| 9| 5| | |
| 9| 0| 0| 8| 0| 8| 0| 0| 7| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| | A |
0.2_PPM | 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| | L |
| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Cytomegaly | 3 | 7 2.1|
Hemorrhage | | 1 2.0|
Hyperplasia | | 3 2.7|
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 59 |
Hyperplasia | 3 | 4 2.3|
Bilateral, Hyperplasia | | 3 2.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 59 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 54 |
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 60 |
Cyst | | 2 |
Pars Distalis, Hyperplasia | | 4 2.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Ultimobranchial Cyst | | 2 |
C-Cell, Hyperplasia | 3 2 | 12 1.9|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 60 |
Cyst | | 1 |
Hyperplasia | 3 | 1 3.0|
Inflammation, Suppurative | 2 | 3 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 59 |
Cyst | X | 2 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Cervix, Muscularis, Hyperplasia | | 2 3.0|
Endometrium, Hyperplasia | | 4 2.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lymph Node | + | 3 |
Renal, Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 59 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 6| 7| 5| 7| 7| 5| 4| | |
DAY ON TEST | 5| 3| 3| 2| 3| 8| 3| 3| 9| 5| | |
| 9| 0| 0| 8| 0| 8| 0| 0| 7| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| | A |
0.2_PPM | 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| | L |
| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia, Lymphoid | | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + M + M + + + | 54 |
Pigmentation | 2 | 2 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Ectopic Tissue | | 2 |
__________________________________________________________________________|____________|
Thymus | + + M + M + M + + + | 55 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Abscess | | 1 4.0|
Ulcer | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Compression | X X X | 16 |
Hemorrhage | 2 1 2 | 6 2.0|
Hydrocephalus | 3 2 | 10 2.6|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 60 |
Inflammation, Chronic | | 5 2.2|
Inflammation, Suppurative | 3 1 | 4 1.8|
Metaplasia, Squamous | 1 1 2 2 1 | 24 1.3|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | 4 4 | 3 4.0|
Foreign Body | | 1 4.0|
Alveolar Epithelium, Hyperplasia | 3 1 | 9 1.9|
Alveolus, Hemorrhage | 1 2 1 | 23 1.4|
Alveolus, Infiltration Cellular, | | |
Multifocal, Histiocyte | 2 | 10 2.1|
Alveolus, Inflammation, Suppurative | | 3 2.0|
Artery, Mineralization | | 1 1.0|
Bronchiole, Pigmentation | 2 2 2 2 2 2 2 2 2 2 | 60 1.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 6| 7| 5| 7| 7| 5| 4| | |
DAY ON TEST | 5| 3| 3| 2| 3| 8| 3| 3| 9| 5| | |
| 9| 0| 0| 8| 0| 8| 0| 0| 7| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| | A |
0.2_PPM | 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| | L |
| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Peribronchiolar, Pigmentation | 1 1 1 1 1 1 1 1 | 35 1.0|
Pleura, Fibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Foreign Body | 3 | 7 2.0|
Hemorrhage | | 1 3.0|
Inflammation, Suppurative | 3 | 12 2.3|
Pigmentation | 1 2 1 1 2 1 3 1 | 57 1.6|
Nasolacrimal Duct, Hemorrhage | | 2 2.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 | 3 2.0|
Respiratory Epithelium, Hyperplasia | 1 2 | 12 1.7|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 3 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
Inflammation, Chronic | | 1 3.0|
Pigmentation | | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 4 |
Cataract | 2 | 4 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Mineralization | 2 2 | 14 2.0|
Nephropathy, Chronic | 2 2 3 2 3 3 4 2 3 2 | 60 2.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 59 |
Transitional Epithelium, Hyperplasia | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 6| 7| 4| 6| 7| 4| 7| 5| 4| 7| 3| 4| 4| 6| 6| 7| 6| 5| 7| 7|
DAY ON TEST | 3| 3| 6| 3| 3| 2| 3| 5| 9| 2| 5| 3| 4| 5| 3| 7| 5| 5| 3| 2| 3| 3| 3| 3| 1|
| 3| 3| 1| 3| 3| 8| 3| 8| 8| 4| 8| 3| 8| 8| 3| 3| 8| 8| 3| 5| 3| 5| 6| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7|
| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + I + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 |
Ulcer | 3 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | X X X X X 3 X |
Clear Cell Focus | X X |
Granuloma, Multifocal | 1 |
Hematopoietic Cell Proliferation | 2 |
Hepatodiaphragmatic Nodule | X |
Infarct | |
Vacuolization Cytoplasmic | |
Biliary Tract, Hyperplasia | 3 3 2 |
Hepatocyte, Hyperplasia | 4 |
__________________________________________________________________________|
Mesentery | + + + |
Hemorrhage | 4 |
Inflammation, Granulomatous | |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Inflammation, Chronic | 2 |
Acinus, Atrophy | 1 1 2 3 2 2 1 1 1 3 |
Artery, Inflammation | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 |
Hyperkeratosis | |
Inflammation, Suppurative | |
Mineralization | 3 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 3 |
Hemorrhage | |
Inflammation, Suppurative | |
Mineralization | 4 |
__________________________________________________________________________|
Tooth | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 6| 7| 4| 6| 7| 4| 7| 5| 4| 7| 3| 4| 4| 6| 6| 7| 6| 5| 7| 7|
DAY ON TEST | 3| 3| 6| 3| 3| 2| 3| 5| 9| 2| 5| 3| 4| 5| 3| 7| 5| 5| 3| 2| 3| 3| 3| 3| 1|
| 3| 3| 1| 3| 3| 8| 3| 8| 8| 4| 8| 3| 8| 8| 3| 3| 8| 8| 3| 5| 3| 5| 6| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7|
| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Blood Vessel | + + + |
Atherosclerosis, Diffuse | |
Mineralization | 3 |
Thrombosis | X |
Aorta, Atherosclerosis | X |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 1 2 1 1 4 1 1 |
Mineralization | 4 |
Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytomegaly | 2 3 4|
Hyperplasia | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 2 3 |
Bilateral, Hyperplasia | 2 3 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + M + + + + + + + M + + M + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Necrosis | |
Pars Distalis, Hyperplasia | 3 3 2 2 3 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | X |
C-Cell, Hyperplasia | 1 1 |
Follicular Cell, Cyst | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X |
Hyperplasia | 4 |
Inflammation, Suppurative | 2 4 4 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 2 2 1 2 3 2|
Epithelium, Hyperplasia | 1 2 2 2 1 |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 6| 7| 4| 6| 7| 4| 7| 5| 4| 7| 3| 4| 4| 6| 6| 7| 6| 5| 7| 7|
DAY ON TEST | 3| 3| 6| 3| 3| 2| 3| 5| 9| 2| 5| 3| 4| 5| 3| 7| 5| 5| 3| 2| 3| 3| 3| 3| 1|
| 3| 3| 1| 3| 3| 8| 3| 8| 8| 4| 8| 3| 8| 8| 3| 3| 8| 8| 3| 5| 3| 5| 6| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7|
| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 2 2 2 2 1 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Arteriole, Inflammation | 3 4 |
Interstitial Cell, Hyperplasia | 2 2 |
Seminiferous Tubule, Atrophy | 4 4 4 4 2 4 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Reticulum Cell | 2 |
Myelofibrosis | 3 |
__________________________________________________________________________|
Lymph Node | +|
Renal, Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + M + + M + + M + + M M + + + + + + +|
Hemorrhage | 4 |
Pigmentation | 4 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + M + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + M + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Mineralization | 2 |
Pigmentation | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Tissue | |
Fibrosis | |
Hyperplasia, Reticulum Cell | 3 |
Necrosis | |
__________________________________________________________________________|
Thymus | + + + + + + + M + + + + + + + + M + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Acanthosis | 4 |
Cyst Epithelial Inclusion | X |
Hyperkeratosis | 4 |
Ulcer | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 6| 7| 4| 6| 7| 4| 7| 5| 4| 7| 3| 4| 4| 6| 6| 7| 6| 5| 7| 7|
DAY ON TEST | 3| 3| 6| 3| 3| 2| 3| 5| 9| 2| 5| 3| 4| 5| 3| 7| 5| 5| 3| 2| 3| 3| 3| 3| 1|
| 3| 3| 1| 3| 3| 8| 3| 8| 8| 4| 8| 3| 8| 8| 3| 3| 8| 8| 3| 5| 3| 5| 6| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7|
| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | X |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
Gliosis | |
Hemorrhage | 1 4 2|
Hydrocephalus | |
Necrosis | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 |
Hyperplasia | 2 |
Inflammation, Chronic | 2 1 |
Inflammation, Suppurative | 2 1 1 2 |
Metaplasia, Squamous | |
Mineralization | 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 3 |
Alveolar Epithelium, Hyperplasia | 2 2 1 3 |
Alveolus, Hemorrhage | 3 2 2 1 1 2 2 2 1 1 |
Alveolus, Infiltration Cellular, | |
Multifocal, Histiocyte | 2 2 2 4 3|
Alveolus, Inflammation, Suppurative | |
Artery, Mineralization | 4 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 3 2 |
Hemorrhage | 2 2 2 |
Inflammation, Suppurative | 1 2 3 1 1 4 3|
Pigmentation | |
Nasolacrimal Duct, Hemorrhage | 2 2 2 2 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | |
Respiratory Epithelium, Hyperplasia | 2 2 1 1 1 3|
Respiratory Epithelium, Metaplasia, | |
Squamous | 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Atrophy | |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 6| 7| 4| 6| 7| 4| 7| 5| 4| 7| 3| 4| 4| 6| 6| 7| 6| 5| 7| 7|
DAY ON TEST | 3| 3| 6| 3| 3| 2| 3| 5| 9| 2| 5| 3| 4| 5| 3| 7| 5| 5| 3| 2| 3| 3| 3| 3| 1|
| 3| 3| 1| 3| 3| 8| 3| 8| 8| 4| 8| 3| 8| 8| 3| 3| 8| 8| 3| 5| 3| 5| 6| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7|
| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Cataract | |
Anterior Chamber, Inflammation, | |
Suppurative | 3 |
Choroid, Iris, Inflammation, Chronic | |
Cornea, Inflammation | 3 |
__________________________________________________________________________|
Zymbal's Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Mineralization | X |
Nephropathy, Chronic | 3 3 2 2 2 3 3 3 3 4 2 3 2 2 3 3 3 4 3 2 3 4|
Cortex, Necrosis | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
_____________________________________________________________________________________________________________________
| 6| 4| 7| 7| 7| 7| 5| 7| 5| 6| 7| 6| 7| 5| 6| 6| 6| 4| 6| 5| 4| 7| 6| 5| 5|
DAY ON TEST | 2| 5| 1| 3| 3| 2| 9| 1| 6| 2| 3| 8| 3| 9| 9| 0| 9| 5| 6| 9| 5| 3| 5| 4| 6|
| 6| 8| 2| 3| 3| 9| 1| 2| 5| 4| 3| 1| 3| 7| 1| 0| 4| 8| 0| 7| 8| 3| 1| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3|
| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + A + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + A + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + A + + A + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Ulcer | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + A + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + A + + A + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A + + A + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X |
Clear Cell Focus | X |
Granuloma, Multifocal | 2 |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X |
Infarct | 4 |
Vacuolization Cytoplasmic | 3 |
Biliary Tract, Hyperplasia | 3 2 3 3 2|
Hepatocyte, Hyperplasia | |
__________________________________________________________________________|
Mesentery | + + + + + + |
Hemorrhage | |
Inflammation, Granulomatous | 4 |
Fat, Necrosis | 3 4 4 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 4 |
Inflammation, Chronic | |
Acinus, Atrophy | 2 3 3 2 3 3 2 2 1 2 2 2 1 2 2 2|
Artery, Inflammation | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 2 3 1 |
Hyperkeratosis | 2 1 |
Inflammation, Suppurative | 2 3 |
Mineralization | |
Ulcer | 4 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Hemorrhage | 4 |
Inflammation, Suppurative | 2 3 |
Mineralization | |
__________________________________________________________________________|
Tooth | + |
Inflammation, Suppurative | 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
_____________________________________________________________________________________________________________________
| 6| 4| 7| 7| 7| 7| 5| 7| 5| 6| 7| 6| 7| 5| 6| 6| 6| 4| 6| 5| 4| 7| 6| 5| 5|
DAY ON TEST | 2| 5| 1| 3| 3| 2| 9| 1| 6| 2| 3| 8| 3| 9| 9| 0| 9| 5| 6| 9| 5| 3| 5| 4| 6|
| 6| 8| 2| 3| 3| 9| 1| 2| 5| 4| 3| 1| 3| 7| 1| 0| 4| 8| 0| 7| 8| 3| 1| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3|
| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Blood Vessel | + + |
Atherosclerosis, Diffuse | X |
Mineralization | 1 |
Thrombosis | |
Aorta, Atherosclerosis | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 |
Mineralization | |
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytomegaly | 2 2 2 3 3 |
Hyperplasia | 2 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 2 2 2 |
Bilateral, Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
Necrosis | 4 |
Pars Distalis, Hyperplasia | 3 3|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + A + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 1 1 1 |
Follicular Cell, Cyst | 2 |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
Hyperplasia | |
Inflammation, Suppurative | 3 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 2 3 3 2 2 2 |
Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
_____________________________________________________________________________________________________________________
| 6| 4| 7| 7| 7| 7| 5| 7| 5| 6| 7| 6| 7| 5| 6| 6| 6| 4| 6| 5| 4| 7| 6| 5| 5|
DAY ON TEST | 2| 5| 1| 3| 3| 2| 9| 1| 6| 2| 3| 8| 3| 9| 9| 0| 9| 5| 6| 9| 5| 3| 5| 4| 6|
| 6| 8| 2| 3| 3| 9| 1| 2| 5| 4| 3| 1| 3| 7| 1| 0| 4| 8| 0| 7| 8| 3| 1| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3|
| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 2 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Arteriole, Inflammation | 3 |
Interstitial Cell, Hyperplasia | 2 2 |
Seminiferous Tubule, Atrophy | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Reticulum Cell | |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + |
Renal, Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + M + + + +|
Hemorrhage | |
Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + M + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | M + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
Inflammation | |
__________________________________________________________________________|
Lymph Node, Mediastinal | M + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Mineralization | |
Pigmentation | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Tissue | X |
Fibrosis | 3 4 4 4 |
Hyperplasia, Reticulum Cell | |
Necrosis | 4 3 4 |
__________________________________________________________________________|
Thymus | + + + + + + + + + M + + + + + M + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Acanthosis | 4 |
Cyst Epithelial Inclusion | X X X X |
Hyperkeratosis | |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
_____________________________________________________________________________________________________________________
| 6| 4| 7| 7| 7| 7| 5| 7| 5| 6| 7| 6| 7| 5| 6| 6| 6| 4| 6| 5| 4| 7| 6| 5| 5|
DAY ON TEST | 2| 5| 1| 3| 3| 2| 9| 1| 6| 2| 3| 8| 3| 9| 9| 0| 9| 5| 6| 9| 5| 3| 5| 4| 6|
| 6| 8| 2| 3| 3| 9| 1| 2| 5| 4| 3| 1| 3| 7| 1| 0| 4| 8| 0| 7| 8| 3| 1| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3|
| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + M + + + +|
Fibrous Osteodystrophy | |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X X |
Gliosis | 3 |
Hemorrhage | 3 4 4 |
Hydrocephalus | 1 1 3 1 |
Necrosis | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + A + + A + + + + + + + + + + + + + + +|
Foreign Body | |
Hyperplasia | |
Inflammation, Chronic | 1 |
Inflammation, Suppurative | 2 2 2 |
Metaplasia, Squamous | 1 |
Mineralization | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | |
Alveolar Epithelium, Hyperplasia | 2 3 2|
Alveolus, Hemorrhage | 3 1 2 2 |
Alveolus, Infiltration Cellular, | |
Multifocal, Histiocyte | 3 3 |
Alveolus, Inflammation, Suppurative | 2 |
Artery, Mineralization | 2 |
__________________________________________________________________________|
Nose | + + + + + + A + + A + + + + + + + + + + + + + + +|
Foreign Body | |
Hemorrhage | 2 2 2 |
Inflammation, Suppurative | 3 1 2 |
Pigmentation | |
Nasolacrimal Duct, Hemorrhage | |
Nasolacrimal Duct, Inflammation, | |
Suppurative | |
Respiratory Epithelium, Hyperplasia | 1 1 |
Respiratory Epithelium, Metaplasia, | |
Squamous | |
__________________________________________________________________________|
Trachea | + + + + + + A + + A + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Atrophy | 4 |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
_____________________________________________________________________________________________________________________
| 6| 4| 7| 7| 7| 7| 5| 7| 5| 6| 7| 6| 7| 5| 6| 6| 6| 4| 6| 5| 4| 7| 6| 5| 5|
DAY ON TEST | 2| 5| 1| 3| 3| 2| 9| 1| 6| 2| 3| 8| 3| 9| 9| 0| 9| 5| 6| 9| 5| 3| 5| 4| 6|
| 6| 8| 2| 3| 3| 9| 1| 2| 5| 4| 3| 1| 3| 7| 1| 0| 4| 8| 0| 7| 8| 3| 1| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3|
| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Cataract | 2 |
Anterior Chamber, Inflammation, | |
Suppurative | |
Choroid, Iris, Inflammation, Chronic | 2 |
Cornea, Inflammation | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Mineralization | |
Nephropathy, Chronic | 3 2 3 3 2 4 3 4 2 4 2 3 2 4 2 4 2 4 3 2 3 2 3 2|
Cortex, Necrosis | 4 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 4 |
Transitional Epithelium, Hyperplasia | 2 1 |
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
__________________________________________________________________________________________________________________________________
| 7| 4| 4| 7| 6| 7| 4| 6| 7| 4| | |
DAY ON TEST | 3| 5| 5| 3| 1| 3| 6| 8| 3| 8| | |
| 3| 8| 8| 3| 7| 3| 4| 3| 3| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| | L |
| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + A | 57 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 58 |
Inflammation, Suppurative | | 1 3.0|
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + A | 57 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + A | 56 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + A | 56 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | | 1 2.0|
Basophilic Focus | | 10 3.0|
Clear Cell Focus | X | 4 |
Granuloma, Multifocal | 2 | 3 1.7|
Hematopoietic Cell Proliferation | | 1 2.0|
Hepatodiaphragmatic Nodule | X | 3 |
Infarct | | 1 4.0|
Vacuolization Cytoplasmic | | 1 3.0|
Biliary Tract, Hyperplasia | 3 | 9 2.7|
Hepatocyte, Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Mesentery | + + + | 12 |
Hemorrhage | 4 | 2 4.0|
Inflammation, Granulomatous | 4 | 2 4.0|
Fat, Necrosis | 3 2 4 | 9 3.1|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Fibrosis | | 2 3.5|
Inflammation, Chronic | | 1 2.0|
Acinus, Atrophy | 2 2 3 | 29 2.0|
Artery, Inflammation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Acanthosis | 3 | 6 2.5|
Hyperkeratosis | 3 | 3 2.0|
Inflammation, Suppurative | 4 | 3 3.0|
Mineralization | | 1 3.0|
Ulcer | | 2 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Erosion | | 1 3.0|
Hemorrhage | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
__________________________________________________________________________________________________________________________________
| 7| 4| 4| 7| 6| 7| 4| 6| 7| 4| | |
DAY ON TEST | 3| 5| 5| 3| 1| 3| 6| 8| 3| 8| | |
| 3| 8| 8| 3| 7| 3| 4| 3| 3| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| | L |
| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation, Suppurative | 4 | 3 3.0|
Mineralization | | 1 4.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
Inflammation, Suppurative | | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 5 |
Atherosclerosis, Diffuse | | 1 |
Mineralization | | 2 2.0|
Thrombosis | | 1 |
Aorta, Atherosclerosis | | 1 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy | 1 2 1 | 17 1.7|
Mineralization | | 1 4.0|
Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Cytomegaly | 3 | 9 2.7|
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
Hyperplasia | 3 | 10 2.5|
Bilateral, Hyperplasia | | 3 2.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
Hyperplasia | 3 | 3 2.3|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 56 |
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 60 |
Hemorrhage | | 1 4.0|
Necrosis | | 1 4.0|
Pars Distalis, Hyperplasia | 2 3 | 10 2.7|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 59 |
Ultimobranchial Cyst | | 1 |
C-Cell, Hyperplasia | 1 3 | 7 1.3|
Follicular Cell, Cyst | | 1 2.0|
Follicular Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
__________________________________________________________________________________________________________________________________
| 7| 4| 4| 7| 6| 7| 4| 6| 7| 4| | |
DAY ON TEST | 3| 5| 5| 3| 1| 3| 6| 8| 3| 8| | |
| 3| 8| 8| 3| 7| 3| 4| 3| 3| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| | L |
| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 60 |
Cyst | X | 7 |
Hyperplasia | | 1 4.0|
Inflammation, Suppurative | | 6 3.2|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 60 |
Inflammation, Suppurative | 1 | 15 2.1|
Epithelium, Hyperplasia | | 6 1.7|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
Inflammation, Suppurative | 3 | 11 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Arteriole, Inflammation | 4 | 4 3.5|
Interstitial Cell, Hyperplasia | 2 | 5 2.0|
Seminiferous Tubule, Atrophy | 4 | 9 3.7|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 2 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Hyperplasia, Reticulum Cell | | 1 2.0|
Myelofibrosis | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + | 3 |
Renal, Hemorrhage | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M M + + M + + + + | 51 |
Hemorrhage | | 1 4.0|
Pigmentation | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 58 |
Hyperplasia, Lymphoid | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 59 |
Hemorrhage | | 1 4.0|
Inflammation | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + | 58 |
Hemorrhage | | 1 3.0|
Mineralization | | 1 2.0|
Pigmentation | 3 | 2 2.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Ectopic Tissue | | 1 |
Fibrosis | 3 | 5 3.6|
Hyperplasia, Reticulum Cell | | 1 3.0|
Necrosis | | 3 3.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
__________________________________________________________________________________________________________________________________
| 7| 4| 4| 7| 6| 7| 4| 6| 7| 4| | |
DAY ON TEST | 3| 5| 5| 3| 1| 3| 6| 8| 3| 8| | |
| 3| 8| 8| 3| 7| 3| 4| 3| 3| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| | L |
| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 56 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Abscess | 1 | 1 1.0|
Acanthosis | | 2 4.0|
Cyst Epithelial Inclusion | | 5 |
Hyperkeratosis | | 1 4.0|
Ulcer | 3 | 2 2.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 59 |
Fibrous Osteodystrophy | | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Compression | X | 6 |
Gliosis | | 1 3.0|
Hemorrhage | | 6 3.0|
Hydrocephalus | | 4 1.5|
Necrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 58 |
Foreign Body | | 1 2.0|
Hyperplasia | | 1 2.0|
Inflammation, Chronic | | 3 1.3|
Inflammation, Suppurative | | 7 1.7|
Metaplasia, Squamous | | 1 1.0|
Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Infiltration Cellular, Histiocyte | | 1 3.0|
Alveolar Epithelium, Hyperplasia | 2 2 | 9 2.1|
Alveolus, Hemorrhage | 1 2 1 1 | 18 1.7|
Alveolus, Infiltration Cellular, | | |
Multifocal, Histiocyte | 3 2 2 | 10 2.6|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 63
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
__________________________________________________________________________________________________________________________________
| 7| 4| 4| 7| 6| 7| 4| 6| 7| 4| | |
DAY ON TEST | 3| 5| 5| 3| 1| 3| 6| 8| 3| 8| | |
| 3| 8| 8| 3| 7| 3| 4| 3| 3| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| | L |
| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolus, Inflammation, Suppurative | | 1 2.0|
Artery, Mineralization | | 2 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 58 |
Foreign Body | | 2 2.5|
Hemorrhage | 3 | 7 2.1|
Inflammation, Suppurative | | 10 2.1|
Pigmentation | 1 | 1 1.0|
Nasolacrimal Duct, Hemorrhage | 2 | 6 2.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 | 1 2.0|
Respiratory Epithelium, Hyperplasia | | 8 1.5|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 58 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 4 |
Atrophy | | 1 4.0|
Cataract | 2 | 2 2.0|
Anterior Chamber, Inflammation, | | |
Suppurative | | 1 3.0|
Choroid, Iris, Inflammation, Chronic | 2 | 2 2.0|
Cornea, Inflammation | | 1 3.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Cyst | | 1 |
Mineralization | | 1 |
Nephropathy, Chronic | 4 2 1 3 2 4 3 4 3 2 | 56 2.8|
Cortex, Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
Inflammation, Suppurative | | 1 4.0|
Transitional Epithelium, Hyperplasia | | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 64
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
_____________________________________________________________________________________________________________________
| 6| 5| 6| 3| 5| 6| 7| 7| 4| 5| 7| 4| 7| 7| 7| 5| 6| 6| 7| 6| 7| 7| 6| 4| 4|
DAY ON TEST | 3| 8| 7| 7| 4| 3| 0| 2| 5| 2| 3| 5| 3| 3| 3| 4| 3| 3| 3| 8| 0| 2| 6| 5| 5|
| 9| 4| 0| 0| 1| 6| 9| 4| 8| 3| 2| 8| 2| 2| 2| 4| 4| 9| 2| 1| 5| 4| 2| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.01 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7|
| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + |
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + |
Basophilic Focus | X X X |
Clear Cell Focus | X |
Eosinophilic Focus | X |
Hepatodiaphragmatic Nodule | X X X |
Necrosis, Focal | |
Vacuolization Cytoplasmic | 2 4 |
Biliary Tract, Hyperplasia | 4 |
Hepatocyte, Hyperplasia | 4 |
__________________________________________________________________________|
Mesentery | + + + |
Inflammation, Granulomatous | |
Fat, Necrosis | 3 3 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + |
Acinus, Atrophy | 2 2 3 3 1 4 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + |
Acanthosis | 1 4 2 2 |
Hyperkeratosis | 3 2 1 |
Inflammation, Suppurative | 2 |
Ulcer | 3 |
Muscularis, Hypoplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + |
Erosion | 3 3 |
Inflammation, Suppurative | 2 |
Mineralization | 3 4 |
Necrosis | 3 |
__________________________________________________________________________|
Tooth | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Mineralization, Diffuse | 3 |
Polyarteritis, Diffuse | |
Mesenteric Artery, Developmental | |
Malformation | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
_____________________________________________________________________________________________________________________
| 6| 5| 6| 3| 5| 6| 7| 7| 4| 5| 7| 4| 7| 7| 7| 5| 6| 6| 7| 6| 7| 7| 6| 4| 4|
DAY ON TEST | 3| 8| 7| 7| 4| 3| 0| 2| 5| 2| 3| 5| 3| 3| 3| 4| 3| 3| 3| 8| 0| 2| 6| 5| 5|
| 9| 4| 0| 0| 1| 6| 9| 4| 8| 3| 2| 8| 2| 2| 2| 4| 4| 9| 2| 1| 5| 4| 2| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.01 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7|
| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Cardiomyopathy | 3 2 4 1 |
Mineralization | 3 4 |
Thrombosis | X |
Myocardium, Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + |
Cytomegaly | 2 3 4 |
Hemorrhage | |
Hyperplasia | 3 3 |
Necrosis | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + |
Hyperplasia | 2 2 3 1 2 4 |
Bilateral, Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + + + + + + M |
Hyperplasia | 2 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + |
Cyst | |
Hemorrhage | |
Pars Distalis, Hyperplasia | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + |
Ultimobranchial Cyst | X X |
C-Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + |
Cyst | X |
Hyperplasia | 3 |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + |
Inflammation, Suppurative | 4 3 3 2 2 2 |
Epithelium, Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + |
Inflammation, Suppurative | 3 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + |
Interstitial Cell, Hyperplasia | 4 3 3 2 3 3 2 |
Seminiferous Tubule, Atrophy | 4 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
_____________________________________________________________________________________________________________________
| 6| 5| 6| 3| 5| 6| 7| 7| 4| 5| 7| 4| 7| 7| 7| 5| 6| 6| 7| 6| 7| 7| 6| 4| 4|
DAY ON TEST | 3| 8| 7| 7| 4| 3| 0| 2| 5| 2| 3| 5| 3| 3| 3| 4| 3| 3| 3| 8| 0| 2| 6| 5| 5|
| 9| 4| 0| 0| 1| 6| 9| 4| 8| 3| 2| 8| 2| 2| 2| 4| 4| 9| 2| 1| 5| 4| 2| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.01 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7|
| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + |
Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + |
__________________________________________________________________________|
Lymph Node, Bronchial | + + M + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + M + + + |
Hemorrhage | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + |
Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + M + + + + + + + + + |
Hemorrhage | |
Pigmentation | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + |
Fibrosis | 4 4 |
Necrosis | |
__________________________________________________________________________|
Thymus | + + + + + + M + + + + + + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + |
Galactocele | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + |
Abscess | |
Acanthosis | 4 4 |
Cyst Epithelial Inclusion | X |
Hyperkeratosis | 3 2 |
Ulcer | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + |
Compression | X X X |
Hemorrhage | 4 4 2 |
Hemorrhage, Multifocal | |
Hydrocephalus | 3 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 |
Inflammation, Chronic | 2 |
Inflammation, Suppurative | 2 2 |
Metaplasia, Squamous | 1 1 1 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
_____________________________________________________________________________________________________________________
| 6| 5| 6| 3| 5| 6| 7| 7| 4| 5| 7| 4| 7| 7| 7| 5| 6| 6| 7| 6| 7| 7| 6| 4| 4|
DAY ON TEST | 3| 8| 7| 7| 4| 3| 0| 2| 5| 2| 3| 5| 3| 3| 3| 4| 3| 3| 3| 8| 0| 2| 6| 5| 5|
| 9| 4| 0| 0| 1| 6| 9| 4| 8| 3| 2| 8| 2| 2| 2| 4| 4| 9| 2| 1| 5| 4| 2| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.01 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7|
| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Congestion | |
Alveolar Epithelium, Hyperplasia | 3 1 |
Alveolus, Hemorrhage | 1 3 4 1 2 1 2 1 1 1|
Alveolus, Infiltration Cellular, | |
Multifocal, Histiocyte | 3 3 2 |
Alveolus, Inflammation, Suppurative | 2 1 |
Artery, Mineralization | 3 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 3 2 |
Hemorrhage | 2 2 |
Inflammation, Suppurative | 2 2 1 1 |
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 2 1 1|
Nasolacrimal Duct, Hemorrhage | |
Nasolacrimal Duct, Inflammation, | |
Suppurative | |
Respiratory Epithelium, Hyperplasia | 1 1 1 |
Respiratory Epithelium, Metaplasia, | |
Squamous | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
Cataract | 2 2 |
Anterior Chamber, Inflammation, | |
Suppurative | 3 |
__________________________________________________________________________|
Harderian Gland | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + |
Mineralization | 4 4 |
Nephropathy, Chronic | 2 2 3 2 4 4 3 4 2 2 2 3 2 4 3 |
Papilla, Necrosis | 3 |
Pelvis, Dilatation | 4 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + |
Inflammation, Suppurative | 4 |
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
_____________________________________________________________________________________________________________________
| 4| 5| 7| 3| 6| 7| 7| 7| 5| 7| 6| 3| 6| 7| 6| 4| 6| 5| 7| 4| 7| 7| 5| 6| 6|
DAY ON TEST | 5| 4| 3| 7| 0| 3| 1| 3| 6| 3| 0| 5| 3| 3| 9| 5| 2| 9| 3| 5| 3| 3| 6| 4| 1|
| 1| 0| 2| 9| 0| 2| 9| 2| 4| 2| 0| 5| 5| 2| 8| 8| 8| 7| 2| 8| 2| 2| 5| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.01 PPM | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3|
| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + A + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | X |
Eosinophilic Focus | |
Hepatodiaphragmatic Nodule | X X X X |
Necrosis, Focal | |
Vacuolization Cytoplasmic | |
Biliary Tract, Hyperplasia | 4 |
Hepatocyte, Hyperplasia | |
__________________________________________________________________________|
Mesentery | + + |
Inflammation, Granulomatous | |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 2 3 1 2 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + +|
Acanthosis | 3 3 |
Hyperkeratosis | 2 |
Inflammation, Suppurative | 3 |
Ulcer | 4 4 |
Muscularis, Hypoplasia | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + +|
Erosion | |
Inflammation, Suppurative | 3 |
Mineralization | |
Necrosis | |
__________________________________________________________________________|
Tooth | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + +|
Mineralization, Diffuse | |
Polyarteritis, Diffuse | 4|
Mesenteric Artery, Developmental | |
Malformation | X |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
_____________________________________________________________________________________________________________________
| 4| 5| 7| 3| 6| 7| 7| 7| 5| 7| 6| 3| 6| 7| 6| 4| 6| 5| 7| 4| 7| 7| 5| 6| 6|
DAY ON TEST | 5| 4| 3| 7| 0| 3| 1| 3| 6| 3| 0| 5| 3| 3| 9| 5| 2| 9| 3| 5| 3| 3| 6| 4| 1|
| 1| 0| 2| 9| 0| 2| 9| 2| 4| 2| 0| 5| 5| 2| 8| 8| 8| 7| 2| 8| 2| 2| 5| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.01 PPM | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3|
| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Cardiomyopathy | 1 2 2 3 |
Mineralization | |
Thrombosis | |
Myocardium, Hemorrhage | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + +|
Cytomegaly | 4 |
Hemorrhage | 1 |
Hyperplasia | 1 |
Necrosis | 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + +|
Hyperplasia | 3 3|
Bilateral, Hyperplasia | 3 3 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + +|
Cyst | X |
Hemorrhage | 3 4|
Pars Distalis, Hyperplasia | 3 3 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + +|
Cyst | X |
Hyperplasia | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 3 2 4 3 3|
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 3 2 1 3 4 |
Seminiferous Tubule, Atrophy | 4 3 3 4 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
_____________________________________________________________________________________________________________________
| 4| 5| 7| 3| 6| 7| 7| 7| 5| 7| 6| 3| 6| 7| 6| 4| 6| 5| 7| 4| 7| 7| 5| 6| 6|
DAY ON TEST | 5| 4| 3| 7| 0| 3| 1| 3| 6| 3| 0| 5| 3| 3| 9| 5| 2| 9| 3| 5| 3| 3| 6| 4| 1|
| 1| 0| 2| 9| 0| 2| 9| 2| 4| 2| 0| 5| 5| 2| 8| 8| 8| 7| 2| 8| 2| 2| 5| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.01 PPM | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3|
| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + +|
Myelofibrosis | 2|
__________________________________________________________________________|
Lymph Node | + + + |
__________________________________________________________________________|
Lymph Node, Bronchial | + + M + + + + + + + + + + M +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Hyperplasia, Lymphoid | 1 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Pigmentation | 3|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 3 3 4 3|
Necrosis | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + +|
Galactocele | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + +|
Abscess | 3 |
Acanthosis | 4 |
Cyst Epithelial Inclusion | X |
Hyperkeratosis | 4 |
Ulcer | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + +|
Compression | X |
Hemorrhage | 3 3 |
Hemorrhage, Multifocal | 3 |
Hydrocephalus | 4 4 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Inflammation, Chronic | |
Inflammation, Suppurative | 1 |
Metaplasia, Squamous | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
_____________________________________________________________________________________________________________________
| 4| 5| 7| 3| 6| 7| 7| 7| 5| 7| 6| 3| 6| 7| 6| 4| 6| 5| 7| 4| 7| 7| 5| 6| 6|
DAY ON TEST | 5| 4| 3| 7| 0| 3| 1| 3| 6| 3| 0| 5| 3| 3| 9| 5| 2| 9| 3| 5| 3| 3| 6| 4| 1|
| 1| 0| 2| 9| 0| 2| 9| 2| 4| 2| 0| 5| 5| 2| 8| 8| 8| 7| 2| 8| 2| 2| 5| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.01 PPM | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3|
| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Congestion | 4 |
Alveolar Epithelium, Hyperplasia | 3 1 2 2 |
Alveolus, Hemorrhage | 2 1 2 2 2 1 1 2 |
Alveolus, Infiltration Cellular, | |
Multifocal, Histiocyte | 3 3 3 2 |
Alveolus, Inflammation, Suppurative | |
Artery, Mineralization | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 3 2 |
Hemorrhage | 2 2 1 2 |
Inflammation, Suppurative | 2 2|
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1|
Nasolacrimal Duct, Hemorrhage | |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 |
Respiratory Epithelium, Hyperplasia | 3 3 1 2 2|
Respiratory Epithelium, Metaplasia, | |
Squamous | 3 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cataract | |
Anterior Chamber, Inflammation, | |
Suppurative | |
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Zymbal's Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + +|
Mineralization | 1 |
Nephropathy, Chronic | 2 2 1 3 3 3 3 1 3 4 3 3 3 4 2 3 3|
Papilla, Necrosis | |
Pelvis, Dilatation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
Page 72
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
__________________________________________________________________________________________________________________________________
| 4| 7| 6| 4| 7| 7| 7| 7| 4| 4| | |
DAY ON TEST | 5| 0| 9| 5| 3| 3| 2| 3| 5| 5| | |
| 8| 4| 5| 8| 2| 2| 6| 2| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.01 PPM | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| | L |
| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + | 34 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + | 34 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + | 34 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + | 32 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + | 34 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + | 33 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + | 32 |
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + | 42 |
Basophilic Focus | | 3 |
Clear Cell Focus | X X | 4 |
Eosinophilic Focus | | 1 |
Hepatodiaphragmatic Nodule | | 7 |
Necrosis, Focal | 4 | 1 4.0|
Vacuolization Cytoplasmic | | 2 3.0|
Biliary Tract, Hyperplasia | | 2 4.0|
Hepatocyte, Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + | 11 |
Inflammation, Granulomatous | 4 | 1 4.0|
Fat, Necrosis | 3 4 4 | 7 3.4|
__________________________________________________________________________|____________|
Pancreas | + + + | 34 |
Acinus, Atrophy | | 13 2.3|
__________________________________________________________________________|____________|
Salivary Glands | + + + | 34 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + | 36 |
Acanthosis | | 6 2.5|
Hyperkeratosis | | 4 2.0|
Inflammation, Suppurative | | 2 2.5|
Ulcer | | 3 3.7|
Muscularis, Hypoplasia | | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + | 35 |
Erosion | | 2 3.0|
Inflammation, Suppurative | | 2 2.5|
Mineralization | | 2 3.5|
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Tooth | + | 1 |
Inflammation, Suppurative | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 73
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
__________________________________________________________________________________________________________________________________
| 4| 7| 6| 4| 7| 7| 7| 7| 4| 4| | |
DAY ON TEST | 5| 0| 9| 5| 3| 3| 2| 3| 5| 5| | |
| 8| 4| 5| 8| 2| 2| 6| 2| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.01 PPM | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| | L |
| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Mineralization, Diffuse | | 1 3.0|
Polyarteritis, Diffuse | | 1 4.0|
Mesenteric Artery, Developmental | | |
Malformation | | 1 |
__________________________________________________________________________|____________|
Heart | + + + | 34 |
Cardiomyopathy | 2 | 9 2.2|
Mineralization | | 2 3.5|
Thrombosis | | 1 |
Myocardium, Hemorrhage | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + | 33 |
Cytomegaly | | 4 3.3|
Hemorrhage | | 1 1.0|
Hyperplasia | | 3 2.3|
Necrosis | | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Medulla | M + + | 34 |
Hyperplasia | | 8 2.5|
Bilateral, Hyperplasia | | 3 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 34 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + | 30 |
Hyperplasia | | 2 2.5|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + | 39 |
Cyst | | 1 |
Hemorrhage | | 2 3.5|
Pars Distalis, Hyperplasia | | 4 2.8|
__________________________________________________________________________|____________|
Thyroid Gland | + + + | 35 |
Ultimobranchial Cyst | | 2 |
C-Cell, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + | 35 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + | 38 |
Cyst | X | 3 |
Hyperplasia | 4 | 2 3.5|
Inflammation, Suppurative | 4 | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 74
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
__________________________________________________________________________________________________________________________________
| 4| 7| 6| 4| 7| 7| 7| 7| 4| 4| | |
DAY ON TEST | 5| 0| 9| 5| 3| 3| 2| 3| 5| 5| | |
| 8| 4| 5| 8| 2| 2| 6| 2| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.01 PPM | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| | L |
| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Prostate | + + + | 36 |
Inflammation, Suppurative | 2 | 13 2.6|
Epithelium, Hyperplasia | | 3 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + | 35 |
Inflammation, Suppurative | | 3 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + | 50 |
Interstitial Cell, Hyperplasia | | 12 2.8|
Seminiferous Tubule, Atrophy | 4 | 8 3.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + | 34 |
Myelofibrosis | | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node | + | 6 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + | 32 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + M | 32 |
Hemorrhage | | 1 3.0|
Hyperplasia, Lymphoid | | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + | 35 |
Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + M | 32 |
Hemorrhage | | 1 2.0|
Pigmentation | 4 | 2 3.5|
__________________________________________________________________________|____________|
Spleen | + + + + | 41 |
Fibrosis | 4 3 | 9 3.3|
Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + + M | 32 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + | 34 |
Galactocele | | 1 |
__________________________________________________________________________|____________|
Skin | + + + | 38 |
Abscess | | 1 3.0|
Acanthosis | | 3 4.0|
Cyst Epithelial Inclusion | | 2 |
Hyperkeratosis | | 3 3.0|
Ulcer | | 2 3.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + | 34 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 75
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
__________________________________________________________________________________________________________________________________
| 4| 7| 6| 4| 7| 7| 7| 7| 4| 4| | |
DAY ON TEST | 5| 0| 9| 5| 3| 3| 2| 3| 5| 5| | |
| 8| 4| 5| 8| 2| 2| 6| 2| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.01 PPM | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| | L |
| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + | 35 |
Compression | X | 5 |
Hemorrhage | 4 | 6 3.3|
Hemorrhage, Multifocal | | 1 3.0|
Hydrocephalus | 4 | 5 3.4|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 60 |
Foreign Body | 3 | 2 2.5|
Inflammation, Chronic | | 1 2.0|
Inflammation, Suppurative | 2 | 4 1.8|
Metaplasia, Squamous | | 4 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | | 1 4.0|
Alveolar Epithelium, Hyperplasia | | 6 2.0|
Alveolus, Hemorrhage | 1 3 1 1 2 | 23 1.7|
Alveolus, Infiltration Cellular, | | |
Multifocal, Histiocyte | | 7 2.7|
Alveolus, Inflammation, Suppurative | | 2 1.5|
Artery, Mineralization | | 3 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Foreign Body | 2 | 5 2.4|
Hemorrhage | 2 2 | 8 1.9|
Inflammation, Suppurative | 3 | 7 1.9|
Pigmentation | 1 1 1 1 1 1 1 | 54 1.1|
Nasolacrimal Duct, Hemorrhage | 2 | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 1 2.0|
Respiratory Epithelium, Hyperplasia | 2 2 1 | 11 1.7|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 2 2.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
Inflammation, Suppurative | | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 4 |
Cataract | | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 76
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
__________________________________________________________________________________________________________________________________
| 4| 7| 6| 4| 7| 7| 7| 7| 4| 4| | |
DAY ON TEST | 5| 0| 9| 5| 3| 3| 2| 3| 5| 5| | |
| 8| 4| 5| 8| 2| 2| 6| 2| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.01 PPM | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| | L |
| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
Anterior Chamber, Inflammation, | | |
Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + | 38 |
Mineralization | | 3 3.0|
Nephropathy, Chronic | 2 3 4 3 3 | 37 2.8|
Papilla, Necrosis | | 1 3.0|
Pelvis, Dilatation | | 2 3.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + | 34 |
Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 77
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
_____________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 7| 7| 7| 7| 5| 4| 4| 6| 5| 7| 5| 7| 2| 7| 4| 5| 4| 4| 4| 4|
DAY ON TEST | 5| 6| 2| 0| 3| 3| 1| 3| 3| 0| 5| 5| 6| 9| 3| 0| 3| 3| 2| 5| 1| 5| 5| 5| 5|
| 8| 4| 3| 9| 1| 1| 0| 1| 1| 6| 8| 8| 6| 7| 1| 6| 1| 3| 4| 8| 6| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.05 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7|
| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + I + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + |
Angiectasis | 4 |
Basophilic Focus | X |
Clear Cell Focus | X X |
Hepatodiaphragmatic Nodule | |
Thrombosis | |
Biliary Tract, Hyperplasia | 4 |
Hepatocyte, Hyperplasia | 4 4 |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Mineralization | |
Fat, Necrosis | 3 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + |
Acinus, Atrophy | 3 3 2 2 2 |
Acinus, Hyperplasia | 3 |
Artery, Inflammation | |
__________________________________________________________________________|
Pharynx | + |
Developmental Malformation | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + |
Acanthosis | 2 3 |
Edema | |
Erosion | |
Hyperkeratosis | 1 |
Inflammation, Suppurative | |
Mineralization | |
Ulcer | 3 |
Muscularis, Hypoplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + |
Edema | |
Inflammation, Suppurative | |
Mineralization | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Polyarteritis, Diffuse | |
Aorta, Mineralization | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 78
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
_____________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 7| 7| 7| 7| 5| 4| 4| 6| 5| 7| 5| 7| 2| 7| 4| 5| 4| 4| 4| 4|
DAY ON TEST | 5| 6| 2| 0| 3| 3| 1| 3| 3| 0| 5| 5| 6| 9| 3| 0| 3| 3| 2| 5| 1| 5| 5| 5| 5|
| 8| 4| 3| 9| 1| 1| 0| 1| 1| 6| 8| 8| 6| 7| 1| 6| 1| 3| 4| 8| 6| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.05 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7|
| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Cardiomyopathy | 2 |
Mineralization | |
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + |
Cytomegaly | 1 2 |
Hyperplasia | 3 |
Metaplasia, Osseous | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + |
Hyperplasia | 3 2 |
Bilateral, Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + M + + |
Hyperplasia | 1 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + I + + + + + + |
Cyst | X |
Hemorrhage | |
Necrosis | |
Pars Distalis, Hyperplasia | 2 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + |
Granuloma Sperm | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + |
Cyst | X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + |
Inflammation, Suppurative | 3 2 2 2 2 |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + |
Inflammation, Suppurative | 1 2 2 |
Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + |
Arteriole, Inflammation | |
Interstitial Cell, Hyperplasia | 2 2 3 3 |
Seminiferous Tubule, Atrophy | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + |
Myelofibrosis | |
_____________________________________________________________________________________________________________________|
Page 79
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
_____________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 7| 7| 7| 7| 5| 4| 4| 6| 5| 7| 5| 7| 2| 7| 4| 5| 4| 4| 4| 4|
DAY ON TEST | 5| 6| 2| 0| 3| 3| 1| 3| 3| 0| 5| 5| 6| 9| 3| 0| 3| 3| 2| 5| 1| 5| 5| 5| 5|
| 8| 4| 3| 9| 1| 1| 0| 1| 1| 6| 8| 8| 6| 7| 1| 6| 1| 3| 4| 8| 6| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.05 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7|
| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node | + + + + |
Pancreatic, Hemorrhage | |
Renal, Hemorrhage | |
Renal, Hyperplasia, Lymphoid | |
Renal, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + |
Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + |
Hyperplasia, Lymphoid | 3 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + |
Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + |
Ectopic Tissue | X |
Fibrosis | 3 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + |
Acanthosis | |
Cyst Epithelial Inclusion | X X |
Hyperkeratosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + |
Inflammation, Suppurative | |
__________________________________________________________________________|
Skeletal Muscle | + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + |
Compression | X X X |
Hemorrhage | 4 |
Hydrocephalus | 3 2 2 4 |
Mineralization | 3 |
Necrosis | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + A + + + + + I + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Inflammation, Suppurative | 2 |
Metaplasia, Squamous | 2 |
Mineralization | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 80
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
_____________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 7| 7| 7| 7| 5| 4| 4| 6| 5| 7| 5| 7| 2| 7| 4| 5| 4| 4| 4| 4|
DAY ON TEST | 5| 6| 2| 0| 3| 3| 1| 3| 3| 0| 5| 5| 6| 9| 3| 0| 3| 3| 2| 5| 1| 5| 5| 5| 5|
| 8| 4| 3| 9| 1| 1| 0| 1| 1| 6| 8| 8| 6| 7| 1| 6| 1| 3| 4| 8| 6| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.05 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7|
| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Congestion | |
Thrombosis | |
Alveolar Epithelium, Hyperplasia | 3 3 3 1 |
Alveolus, Hemorrhage | 1 1 1 1 1 1 1 2 2 2 2 1 1 1 1|
Alveolus, Infiltration Cellular, | |
Multifocal, Histiocyte | 3 3 4 1 3 2 2 |
Alveolus, Inflammation, Suppurative | |
Artery, Mineralization | 1 1 1 1|
Bronchiole, Pigmentation | 1 |
Peribronchiolar, Pigmentation | 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 2 |
Hemorrhage | 2 3 2 2 |
Inflammation, Suppurative | 1 |
Pigmentation | 1 1 1 1 2 2 1 2 2 1 1 1 1 1 2 2 2 1 1 1 2 1 1 1 1|
Nasolacrimal Duct, Hemorrhage | 2 2 2 2 2 2|
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 |
Respiratory Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Trachea | + A + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + |
Cataract | 2 2 |
__________________________________________________________________________|
Harderian Gland | |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + |
Cyst | X |
Mineralization | |
Nephropathy, Chronic | 3 3 4 3 4 1 3 1 1 2 2 |
__________________________________________________________________________|
Urethra | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + |
Inflammation, Suppurative | 2 |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 81
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 4| 7| 3| 5| 6| 7| 5| 7| 7| 7| 7| 7| 6| 7| 4| 7| 4| 7|
DAY ON TEST | 0| 3| 3| 3| 1| 4| 3| 5| 3| 6| 6| 8| 3| 4| 1| 3| 0| 3| 0| 1| 3| 5| 3| 7| 3|
| 1| 1| 1| 1| 2| 7| 1| 8| 1| 5| 5| 0| 1| 1| 2| 1| 4| 1| 5| 1| 1| 8| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.05 PPM | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3|
| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + A A + + + + + + + A |
__________________________________________________________________________|
Intestine Large, Rectum | + + A A + + + + + + + A |
__________________________________________________________________________|
Intestine Large, Cecum | + + A A + + + + + + + A |
__________________________________________________________________________|
Intestine Small, Duodenum | + + A A + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + A A + + + + + + + A |
__________________________________________________________________________|
Intestine Small, Ileum | + + A A + + + + + + + A |
__________________________________________________________________________|
Liver | + + + + + + + A + + + + + + + + + |
Angiectasis | |
Basophilic Focus | X |
Clear Cell Focus | X |
Hepatodiaphragmatic Nodule | X |
Thrombosis | |
Biliary Tract, Hyperplasia | |
Hepatocyte, Hyperplasia | 4 |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Mineralization | |
Fat, Necrosis | 4 3 2 |
__________________________________________________________________________|
Pancreas | + + + A + + + + + + + + |
Acinus, Atrophy | 2 |
Acinus, Hyperplasia | |
Artery, Inflammation | 4 |
__________________________________________________________________________|
Pharynx | + |
Developmental Malformation | |
__________________________________________________________________________|
Salivary Glands | + + + A + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + A + + + + + + + + |
Acanthosis | 3 3 2 |
Edema | 3 |
Erosion | 4 |
Hyperkeratosis | 3 |
Inflammation, Suppurative | 2 |
Mineralization | 3 |
Ulcer | 3 |
Muscularis, Hypoplasia | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + A + + + + + + + + |
Edema | 3 |
Inflammation, Suppurative | 2 |
Mineralization | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Polyarteritis, Diffuse | 4 |
Aorta, Mineralization | |
__________________________________________________________________________|
Heart | + + + A + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 82
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 4| 7| 3| 5| 6| 7| 5| 7| 7| 7| 7| 7| 6| 7| 4| 7| 4| 7|
DAY ON TEST | 0| 3| 3| 3| 1| 4| 3| 5| 3| 6| 6| 8| 3| 4| 1| 3| 0| 3| 0| 1| 3| 5| 3| 7| 3|
| 1| 1| 1| 1| 2| 7| 1| 8| 1| 5| 5| 0| 1| 1| 2| 1| 4| 1| 5| 1| 1| 8| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.05 PPM | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3|
| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Cardiomyopathy | 2 |
Mineralization | |
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + A + + + + + + + + |
Cytomegaly | 4 2 |
Hyperplasia | |
Metaplasia, Osseous | |
__________________________________________________________________________|
Adrenal Medulla | + + + A + + + + + + + + |
Hyperplasia | 3 2 4 |
Bilateral, Hyperplasia | 3 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + A + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | M + + M + + + + + + + + |
Hyperplasia | 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + A + + + + + + + + + + + + |
Cyst | X X |
Hemorrhage | 4 |
Necrosis | 4 |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + A + + + + + + + + |
Granuloma Sperm | 3 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + |
Cyst | |
__________________________________________________________________________|
Prostate | + + + A + + + + + + + + + + +|
Inflammation, Suppurative | 2 3 3 2 4 4 2 |
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + A + + + + + + + + + +|
Inflammation, Suppurative | 4 |
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + A + + + + + + + + + + + + + +|
Arteriole, Inflammation | 4 4|
Interstitial Cell, Hyperplasia | 2 3 3 2 |
Seminiferous Tubule, Atrophy | 3 4 4 3 4|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + A + + + + + + + + |
Myelofibrosis | 2 |
_____________________________________________________________________________________________________________________|
Page 83
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 4| 7| 3| 5| 6| 7| 5| 7| 7| 7| 7| 7| 6| 7| 4| 7| 4| 7|
DAY ON TEST | 0| 3| 3| 3| 1| 4| 3| 5| 3| 6| 6| 8| 3| 4| 1| 3| 0| 3| 0| 1| 3| 5| 3| 7| 3|
| 1| 1| 1| 1| 2| 7| 1| 8| 1| 5| 5| 0| 1| 1| 2| 1| 4| 1| 5| 1| 1| 8| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.05 PPM | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3|
| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node | + + + + + |
Pancreatic, Hemorrhage | 4 |
Renal, Hemorrhage | 4 |
Renal, Hyperplasia, Lymphoid | 4 |
Renal, Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + A + + + + + + + + + |
Hemorrhage | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + A + + + + + + + + |
Hyperplasia, Lymphoid | 3 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + A + + + + + + + + + |
Hemorrhage | 4 3 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + A + + + + + + + + |
__________________________________________________________________________|
Spleen | + + + + + + A + + + + + + + + + +|
Ectopic Tissue | |
Fibrosis | 3 3 3 3 3|
__________________________________________________________________________|
Thymus | + + + A + + + + + + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + A + + + + + + + + |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + |
Acanthosis | 4 |
Cyst Epithelial Inclusion | X X |
Hyperkeratosis | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + A + + + + + + + + |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + A + + + + + + + + + |
Compression | X X X X X |
Hemorrhage | 1 3 1 |
Hydrocephalus | 4 4 2 3 2 |
Mineralization | |
Necrosis | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + A + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
Inflammation, Suppurative | 3 |
Metaplasia, Squamous | 1 1 1 1 1 |
Mineralization | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 84
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 4| 7| 3| 5| 6| 7| 5| 7| 7| 7| 7| 7| 6| 7| 4| 7| 4| 7|
DAY ON TEST | 0| 3| 3| 3| 1| 4| 3| 5| 3| 6| 6| 8| 3| 4| 1| 3| 0| 3| 0| 1| 3| 5| 3| 7| 3|
| 1| 1| 1| 1| 2| 7| 1| 8| 1| 5| 5| 0| 1| 1| 2| 1| 4| 1| 5| 1| 1| 8| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.05 PPM | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3|
| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Congestion | 4 |
Thrombosis | |
Alveolar Epithelium, Hyperplasia | 1 1 |
Alveolus, Hemorrhage | 1 1 1 1 1 2 |
Alveolus, Infiltration Cellular, | |
Multifocal, Histiocyte | 3 |
Alveolus, Inflammation, Suppurative | 4 |
Artery, Mineralization | 1 |
Bronchiole, Pigmentation | |
Peribronchiolar, Pigmentation | |
__________________________________________________________________________|
Nose | + + + + + + + + + A + + + + + + + + + + + + + + +|
Foreign Body | 4 1 2 2 2 |
Hemorrhage | 3 3 |
Inflammation, Suppurative | 2 3 2 |
Pigmentation | 1 2 2 1 2 1 1 2 1 1 1 1 1 2 1 2 1 1 2 1 2 1 2|
Nasolacrimal Duct, Hemorrhage | 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 |
Respiratory Epithelium, Hyperplasia | 3 1 2 1 1 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + A + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + + |
Cataract | 2 2 |
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + A + + + + + + + + + + + +|
Cyst | X |
Mineralization | |
Nephropathy, Chronic | 4 3 1 4 3 3 2 4 3 3 4 3 3 4 3 4|
__________________________________________________________________________|
Urethra | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Urinary Bladder | + + + A + + + + + + + + |
Inflammation, Suppurative | 3 |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 85
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 5| 7| 6| 7| 7| 6| 7| | |
DAY ON TEST | 0| 3| 3| 3| 0| 3| 3| 3| 4| 3| | |
| 2| 1| 1| 5| 5| 5| 1| 1| 9| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
0.05 PPM | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| | L |
| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + | 28 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + | 25 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + | 24 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + + + + | 23 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + | 26 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + + + | 23 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + | 24 |
__________________________________________________________________________|____________|
Liver | + + + + + + | 36 |
Angiectasis | | 1 4.0|
Basophilic Focus | | 2 |
Clear Cell Focus | | 3 |
Hepatodiaphragmatic Nodule | | 1 |
Thrombosis | X | 1 |
Biliary Tract, Hyperplasia | | 1 4.0|
Hepatocyte, Hyperplasia | 4 | 4 4.0|
__________________________________________________________________________|____________|
Mesentery | + + | 8 |
Fat, Mineralization | 3 | 1 3.0|
Fat, Necrosis | 4 4 | 7 3.4|
__________________________________________________________________________|____________|
Pancreas | + + + + + + | 30 |
Acinus, Atrophy | 2 3 2 | 9 2.3|
Acinus, Hyperplasia | | 1 3.0|
Artery, Inflammation | 4 | 2 4.0|
__________________________________________________________________________|____________|
Pharynx | + | 3 |
Developmental Malformation | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + | 27 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + | 30 |
Acanthosis | 2 | 6 2.5|
Edema | | 1 3.0|
Erosion | | 1 4.0|
Hyperkeratosis | 2 | 3 2.0|
Inflammation, Suppurative | | 1 2.0|
Mineralization | 4 | 2 3.5|
Ulcer | | 2 3.0|
Muscularis, Hypoplasia | | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + | 30 |
Edema | | 1 3.0|
Inflammation, Suppurative | | 1 2.0|
Mineralization | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 86
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 5| 7| 6| 7| 7| 6| 7| | |
DAY ON TEST | 0| 3| 3| 3| 0| 3| 3| 3| 4| 3| | |
| 2| 1| 1| 5| 5| 5| 1| 1| 9| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
0.05 PPM | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| | L |
| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 2 |
Polyarteritis, Diffuse | | 1 4.0|
Aorta, Mineralization | 3 | 1 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + | 27 |
Cardiomyopathy | 3 2 | 4 2.3|
Mineralization | 4 | 1 4.0|
Thrombosis | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + | 27 |
Cytomegaly | | 4 2.3|
Hyperplasia | | 1 3.0|
Metaplasia, Osseous | 3 | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + | 28 |
Hyperplasia | 1 1 | 7 2.3|
Bilateral, Hyperplasia | 3 | 3 2.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + | 29 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + | 25 |
Hyperplasia | 4 | 3 2.7|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + | 38 |
Cyst | | 3 |
Hemorrhage | | 1 4.0|
Necrosis | | 1 4.0|
Pars Distalis, Hyperplasia | 3 | 3 2.7|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + | 33 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + | 27 |
Granuloma Sperm | | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + | 30 |
Cyst | | 1 |
__________________________________________________________________________|____________|
Prostate | + + + + + | 30 |
Inflammation, Suppurative | 3 4 | 14 2.7|
Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + | 29 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 87
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 5| 7| 6| 7| 7| 6| 7| | |
DAY ON TEST | 0| 3| 3| 3| 0| 3| 3| 3| 4| 3| | |
| 2| 1| 1| 5| 5| 5| 1| 1| 9| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
0.05 PPM | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| | L |
| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Suppurative | 3 | 5 2.4|
Epithelium, Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 49 |
Arteriole, Inflammation | | 2 4.0|
Interstitial Cell, Hyperplasia | | 8 2.5|
Seminiferous Tubule, Atrophy | 4 4 4 4 | 10 3.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + | 27 |
Myelofibrosis | 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + | 11 |
Pancreatic, Hemorrhage | | 1 4.0|
Renal, Hemorrhage | | 1 4.0|
Renal, Hyperplasia, Lymphoid | | 1 4.0|
Renal, Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + + + + | 28 |
Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + | 30 |
Hyperplasia, Lymphoid | | 4 2.8|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + | 31 |
Hemorrhage | | 2 3.5|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + | 28 |
__________________________________________________________________________|____________|
Spleen | + + + + + + | 37 |
Ectopic Tissue | | 1 |
Fibrosis | 2 2 | 9 2.8|
__________________________________________________________________________|____________|
Thymus | + + + + + | 28 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + | 27 |
__________________________________________________________________________|____________|
Skin | + + + + + + | 34 |
Acanthosis | | 1 4.0|
Cyst Epithelial Inclusion | | 4 |
Hyperkeratosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + | 27 |
Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 88
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 5| 7| 6| 7| 7| 6| 7| | |
DAY ON TEST | 0| 3| 3| 3| 0| 3| 3| 3| 4| 3| | |
| 2| 1| 1| 5| 5| 5| 1| 1| 9| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
0.05 PPM | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| | L |
| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + | 29 |
Compression | X | 9 |
Hemorrhage | 3 | 5 2.4|
Hydrocephalus | 1 | 10 2.7|
Mineralization | | 1 3.0|
Necrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 57 |
Inflammation, Chronic | | 1 1.0|
Inflammation, Suppurative | | 2 2.5|
Metaplasia, Squamous | | 6 1.2|
Mineralization | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | | 1 4.0|
Thrombosis | X | 1 |
Alveolar Epithelium, Hyperplasia | | 6 2.0|
Alveolus, Hemorrhage | 2 1 1 | 24 1.3|
Alveolus, Infiltration Cellular, | | |
Multifocal, Histiocyte | 2 3 | 10 2.6|
Alveolus, Inflammation, Suppurative | | 1 4.0|
Artery, Mineralization | 3 1 | 7 1.3|
Bronchiole, Pigmentation | | 1 1.0|
Peribronchiolar, Pigmentation | | 2 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 59 |
Foreign Body | 2 | 8 2.1|
Hemorrhage | 2 | 7 2.4|
Inflammation, Suppurative | 2 3 | 6 2.2|
Pigmentation | 1 2 2 1 1 1 2 2 1 2 | 58 1.4|
Nasolacrimal Duct, Hemorrhage | | 7 2.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 2 2.0|
Respiratory Epithelium, Hyperplasia | 2 2 | 9 1.7|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 58 |
Inflammation, Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 89
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 5| 7| 6| 7| 7| 6| 7| | |
DAY ON TEST | 0| 3| 3| 3| 0| 3| 3| 3| 4| 3| | |
| 2| 1| 1| 5| 5| 5| 1| 1| 9| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
0.05 PPM | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| | L |
| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 7 |
Cataract | 2 | 5 2.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + | 36 |
Cyst | | 2 |
Mineralization | 4 | 1 4.0|
Nephropathy, Chronic | 4 2 3 2 4 4 | 33 2.9|
__________________________________________________________________________|____________|
Urethra | + | 1 |
Inflammation, Suppurative | 4 | 1 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + | 27 |
Inflammation, Suppurative | 3 | 3 2.7|
Transitional Epithelium, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 90
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
_____________________________________________________________________________________________________________________
| 7| 5| 6| 6| 7| 4| 5| 7| 4| 6| 5| 5| 5| 7| 1| 4| 4| 7| 5| 6| 4| 7| 6| 7| 6|
DAY ON TEST | 3| 0| 0| 9| 3| 8| 8| 3| 5| 2| 8| 4| 3| 3| 8| 7| 5| 3| 8| 3| 5| 0| 1| 3| 6|
| 0| 0| 0| 5| 0| 5| 5| 0| 8| 8| 2| 2| 4| 0| 0| 4| 8| 0| 9| 9| 8| 9| 2| 0| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0.2_PPM | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7|
| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + A + + + + + + + + + + + + + +|
Mineralization | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 4 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + A + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X |
Clear Cell Focus | X X|
Granuloma, Multifocal | |
Hepatodiaphragmatic Nodule | |
Hyperplasia | |
Vacuolization Cytoplasmic | 4 4 |
Biliary Tract, Hyperplasia | 1 |
__________________________________________________________________________|
Mesentery | + + + + + + + |
Inflammation, Granulomatous | |
Fat, Necrosis | 3 4 2 3 3 3 |
__________________________________________________________________________|
Oral Mucosa | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
Acinus, Atrophy | 3 1 2 1 3 2 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 4 3 3 3 |
Edema | |
Hyperkeratosis | 3 |
Inflammation, Suppurative | 3 3 |
Mineralization | |
Ulcer | |
Muscularis, Hypoplasia | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Erosion | |
Inflammation, Suppurative | 3 3 |
Mineralization | |
Serosa, Fibrosis | 2 |
__________________________________________________________________________|
Tooth | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
_____________________________________________________________________________________________________________________|
Page 91
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
_____________________________________________________________________________________________________________________
| 7| 5| 6| 6| 7| 4| 5| 7| 4| 6| 5| 5| 5| 7| 1| 4| 4| 7| 5| 6| 4| 7| 6| 7| 6|
DAY ON TEST | 3| 0| 0| 9| 3| 8| 8| 3| 5| 2| 8| 4| 3| 3| 8| 7| 5| 3| 8| 3| 5| 0| 1| 3| 6|
| 0| 0| 0| 5| 0| 5| 5| 0| 8| 8| 2| 2| 4| 0| 0| 4| 8| 0| 9| 9| 8| 9| 2| 0| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0.2_PPM | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7|
| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Atherosclerosis, Diffuse | |
Mineralization, Diffuse | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 2 1 2 2 2 2 2 2 2 1 |
Mineralization | |
Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytomegaly | 3 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 2 3 4 1 |
Bilateral, Hyperplasia | 3 4 4 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + + + + + + + + + + + + M +|
Hyperplasia | 1 2 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
Hemorrhage | 4 |
Pars Distalis, Hyperplasia | 2 2 3 |
Pars Intermedia, Hyperplasia | 4 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | X X X |
C-Cell, Hyperplasia | 2 3 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 2 2 2 3 2 |
Epithelium, Hyperplasia | 1 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 1 1 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Arteriole, Inflammation | 3 4 |
Interstitial Cell, Hyperplasia | 1 2 |
Seminiferous Tubule, Atrophy | 3 3 4 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 92
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
_____________________________________________________________________________________________________________________
| 7| 5| 6| 6| 7| 4| 5| 7| 4| 6| 5| 5| 5| 7| 1| 4| 4| 7| 5| 6| 4| 7| 6| 7| 6|
DAY ON TEST | 3| 0| 0| 9| 3| 8| 8| 3| 5| 2| 8| 4| 3| 3| 8| 7| 5| 3| 8| 3| 5| 0| 1| 3| 6|
| 0| 0| 0| 5| 0| 5| 5| 0| 8| 8| 2| 2| 4| 0| 0| 4| 8| 0| 9| 9| 8| 9| 2| 0| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0.2_PPM | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7|
| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 3 3 |
__________________________________________________________________________|
Lymph Node | + + + + |
Renal, Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + M + + + + + + + M + + + + + + + +|
Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Lymphoid | 3 |
Inflammation, Chronic | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + M + + + + + + + + + + + +|
Pigmentation | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Tissue | X X |
Fibrosis | 3 2 4|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | X |
Hyperplasia | |
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 2 |
Cyst Epithelial Inclusion | X X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
Mineralization | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X |
Hemorrhage | 3 1 1 3 |
Hydrocephalus | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | M + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 93
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
_____________________________________________________________________________________________________________________
| 7| 5| 6| 6| 7| 4| 5| 7| 4| 6| 5| 5| 5| 7| 1| 4| 4| 7| 5| 6| 4| 7| 6| 7| 6|
DAY ON TEST | 3| 0| 0| 9| 3| 8| 8| 3| 5| 2| 8| 4| 3| 3| 8| 7| 5| 3| 8| 3| 5| 0| 1| 3| 6|
| 0| 0| 0| 5| 0| 5| 5| 0| 8| 8| 2| 2| 4| 0| 0| 4| 8| 0| 9| 9| 8| 9| 2| 0| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0.2_PPM | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7|
| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Chronic | 1|
Inflammation, Suppurative | 3 1 2 |
Metaplasia, Squamous | 2 1|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | 3 |
Alveolus, Hemorrhage | 1 2 2 4 1 1 1 2 |
Alveolus, Infiltration Cellular, | |
Multifocal, Histiocyte | 3 1 2 3 3|
Alveolus, Inflammation, Suppurative | 2 |
Artery, Mineralization | |
Bronchiole, Pigmentation | 1 1 1 2 2 1 1 1 1 1 1 1 1 2 1 1 2 2 1 1 1 2 2 1|
Peribronchiolar, Pigmentation | 1 2 1 1 2 2 3 1 |
Pleura, Fibrosis | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 2 |
Hemorrhage | 2 3 3 3 2 4 |
Inflammation, Suppurative | 1 3 |
Pigmentation | 2 2 2 2 2 1 2 2 1 2 2 2 2 1 2 2 1 2 2 2 3 1|
Nasolacrimal Duct, Hemorrhage | 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 2 |
Respiratory Epithelium, Hyperplasia | 2 1 1 1 2 |
Respiratory Epithelium, Metaplasia, | |
Squamous | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pigmentation | 1 1 1 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + + + |
Cataract | 2 |
Anterior Chamber, Hemorrhage | 2 |
Choroid, Iris, Inflammation, Chronic | 3 |
Cornea, Inflammation | |
__________________________________________________________________________|
Harderian Gland | |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Mineralization | 1 2 |
Nephropathy, Chronic | 3 2 4 3 4 3 4 4 2 4 3 3 3 4 1 2 2 2 4 2 4 2 3 2|
Pelvis, Dilatation | 2 |
Pelvis, Transitional Epithelium, | |
_____________________________________________________________________________________________________________________|
Page 94
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
_____________________________________________________________________________________________________________________
| 7| 5| 6| 6| 7| 4| 5| 7| 4| 6| 5| 5| 5| 7| 1| 4| 4| 7| 5| 6| 4| 7| 6| 7| 6|
DAY ON TEST | 3| 0| 0| 9| 3| 8| 8| 3| 5| 2| 8| 4| 3| 3| 8| 7| 5| 3| 8| 3| 5| 0| 1| 3| 6|
| 0| 0| 0| 5| 0| 5| 5| 0| 8| 8| 2| 2| 4| 0| 0| 4| 8| 0| 9| 9| 8| 9| 2| 0| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0.2_PPM | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7|
| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Hyperplasia | |
Renal Tubule, Hyperplasia | 4 4 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 95
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
_____________________________________________________________________________________________________________________
| 6| 4| 4| 2| 7| 4| 7| 6| 6| 6| 7| 4| 4| 6| 6| 6| 7| 7| 7| 7| 4| 6| 7| 7| 5|
DAY ON TEST | 2| 5| 5| 2| 3| 5| 0| 1| 8| 8| 2| 5| 5| 0| 3| 2| 3| 3| 0| 3| 5| 2| 3| 2| 4|
| 8| 8| 8| 0| 0| 8| 4| 7| 3| 1| 3| 8| 8| 0| 9| 1| 0| 0| 4| 0| 8| 0| 0| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.2_PPM | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3|
| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 4 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X |
Clear Cell Focus | X X |
Granuloma, Multifocal | 1 2 |
Hepatodiaphragmatic Nodule | X |
Hyperplasia | 4 4 3|
Vacuolization Cytoplasmic | 2 |
Biliary Tract, Hyperplasia | 3 |
__________________________________________________________________________|
Mesentery | + + + + |
Inflammation, Granulomatous | 4 4 |
Fat, Necrosis | 4 3 4 3 |
__________________________________________________________________________|
Oral Mucosa | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Acinus, Atrophy | 2 1 3 3 2 2 3 3 2 2|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Edema | 4|
Hyperkeratosis | |
Inflammation, Suppurative | |
Mineralization | 4 |
Ulcer | |
Muscularis, Hypoplasia | 4 4 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 4|
Erosion | 4|
Inflammation, Suppurative | |
Mineralization | 4 |
Serosa, Fibrosis | |
__________________________________________________________________________|
Tooth | + |
Inflammation, Suppurative | 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + |
_____________________________________________________________________________________________________________________|
Page 96
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
_____________________________________________________________________________________________________________________
| 6| 4| 4| 2| 7| 4| 7| 6| 6| 6| 7| 4| 4| 6| 6| 6| 7| 7| 7| 7| 4| 6| 7| 7| 5|
DAY ON TEST | 2| 5| 5| 2| 3| 5| 0| 1| 8| 8| 2| 5| 5| 0| 3| 2| 3| 3| 0| 3| 5| 2| 3| 2| 4|
| 8| 8| 8| 0| 0| 8| 4| 7| 3| 1| 3| 8| 8| 0| 9| 1| 0| 0| 4| 0| 8| 0| 0| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.2_PPM | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3|
| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Atherosclerosis, Diffuse | X |
Mineralization, Diffuse | 4 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 2 |
Mineralization | 4 |
Thrombosis | X X|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytomegaly | 2 1 2 3 3 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + M +|
Hyperplasia | 2 3 2 3 |
Bilateral, Hyperplasia | 3 3 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + M + + + + + + + + + +|
Hyperplasia | 4 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Hemorrhage | |
Pars Distalis, Hyperplasia | 2 4 |
Pars Intermedia, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 1 1 3 1 1|
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + M + + + + + + + + + + + + + + + M +|
Cyst | X X X |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 2 2 3 3 4 |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Arteriole, Inflammation | 3 3 3 |
Interstitial Cell, Hyperplasia | 1 2 2 3 2 2 |
Seminiferous Tubule, Atrophy | 4 3 4 3 3 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 97
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
_____________________________________________________________________________________________________________________
| 6| 4| 4| 2| 7| 4| 7| 6| 6| 6| 7| 4| 4| 6| 6| 6| 7| 7| 7| 7| 4| 6| 7| 7| 5|
DAY ON TEST | 2| 5| 5| 2| 3| 5| 0| 1| 8| 8| 2| 5| 5| 0| 3| 2| 3| 3| 0| 3| 5| 2| 3| 2| 4|
| 8| 8| 8| 0| 0| 8| 4| 7| 3| 1| 3| 8| 8| 0| 9| 1| 0| 0| 4| 0| 8| 0| 0| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.2_PPM | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3|
| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 1 2 |
__________________________________________________________________________|
Lymph Node | + + +|
Renal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Bronchial | + M M M + + + + + + + + M + + + + + + + + + + + +|
Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Hyperplasia, Lymphoid | 4 |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + M + + + + + + + + + + + + + + +|
Pigmentation | 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Tissue | X |
Fibrosis | 2 3 1 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + M + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | X |
Hyperplasia | 2 3 |
Inflammation, Suppurative | 3 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Cyst Epithelial Inclusion | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + |
Mineralization | 4 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X |
Hemorrhage | 1 4 |
Hydrocephalus | 3 2 2 |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 98
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
_____________________________________________________________________________________________________________________
| 6| 4| 4| 2| 7| 4| 7| 6| 6| 6| 7| 4| 4| 6| 6| 6| 7| 7| 7| 7| 4| 6| 7| 7| 5|
DAY ON TEST | 2| 5| 5| 2| 3| 5| 0| 1| 8| 8| 2| 5| 5| 0| 3| 2| 3| 3| 0| 3| 5| 2| 3| 2| 4|
| 8| 8| 8| 0| 0| 8| 4| 7| 3| 1| 3| 8| 8| 0| 9| 1| 0| 0| 4| 0| 8| 0| 0| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.2_PPM | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3|
| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Chronic | |
Inflammation, Suppurative | 1 |
Metaplasia, Squamous | 1 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | 2 3 2 |
Alveolus, Hemorrhage | 2 1 1 2 2 1 2 3 2 2 1 |
Alveolus, Infiltration Cellular, | |
Multifocal, Histiocyte | 4 1 3 3 4 4 4 4 |
Alveolus, Inflammation, Suppurative | |
Artery, Mineralization | 2 4 |
Bronchiole, Pigmentation | 1 1 1 1 2 1 1 1 1 2 2 1 1 2 2 1 2 2 2 2 1 1 2 1 1|
Peribronchiolar, Pigmentation | 1 1 1 3 2 1 1 1 1 |
Pleura, Fibrosis | 4 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 3 4 3 |
Hemorrhage | 2 2 |
Inflammation, Suppurative | 1 2 2 3 2 3 3 |
Pigmentation | 2 1 1 1 2 2 3 2 1 2 1 2 2 2 2 2 1 2 2 1 2 1 1|
Nasolacrimal Duct, Hemorrhage | 2 2 2 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | |
Respiratory Epithelium, Hyperplasia | 4 3 1 2 3 |
Respiratory Epithelium, Metaplasia, | |
Squamous | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pigmentation | 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + +|
Cataract | 2 |
Anterior Chamber, Hemorrhage | |
Choroid, Iris, Inflammation, Chronic | |
Cornea, Inflammation | 4 |
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Mineralization | |
Nephropathy, Chronic | 3 2 2 1 3 1 3 3 3 4 4 2 1 3 3 4 4 3 4 3 1 4 4 4 2|
Pelvis, Dilatation | |
Pelvis, Transitional Epithelium, | |
_____________________________________________________________________________________________________________________|
Page 99
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
_____________________________________________________________________________________________________________________
| 6| 4| 4| 2| 7| 4| 7| 6| 6| 6| 7| 4| 4| 6| 6| 6| 7| 7| 7| 7| 4| 6| 7| 7| 5|
DAY ON TEST | 2| 5| 5| 2| 3| 5| 0| 1| 8| 8| 2| 5| 5| 0| 3| 2| 3| 3| 0| 3| 5| 2| 3| 2| 4|
| 8| 8| 8| 0| 0| 8| 4| 7| 3| 1| 3| 8| 8| 0| 9| 1| 0| 0| 4| 0| 8| 0| 0| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.2_PPM | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3|
| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Hyperplasia | 3 |
Renal Tubule, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
Transitional Epithelium, Hyperplasia | 4 |
_____________________________________________________________________________________________________________________|
Page 100
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 4| 6| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 5| 3| 6| 5| 3| 1| 3| 1| 3| | |
| 0| 8| 0| 0| 3| 0| 2| 0| 9| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.2_PPM | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| | L |
| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 59 |
Mineralization | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 60 |
Ulcer | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Basophilic Focus | | 4 |
Clear Cell Focus | X | 5 |
Granuloma, Multifocal | | 2 1.5|
Hepatodiaphragmatic Nodule | | 1 |
Hyperplasia | | 3 3.7|
Vacuolization Cytoplasmic | | 3 3.3|
Biliary Tract, Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + | 14 |
Inflammation, Granulomatous | | 2 4.0|
Fat, Necrosis | 4 4 | 12 3.3|
__________________________________________________________________________|____________|
Oral Mucosa | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Fibrosis | | 1 3.0|
Acinus, Atrophy | 2 1 2 1 1 | 22 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Acanthosis | 2 3 | 6 3.0|
Edema | | 1 4.0|
Hyperkeratosis | | 1 3.0|
Inflammation, Suppurative | | 2 3.0|
Mineralization | | 1 4.0|
Ulcer | 3 | 1 3.0|
Muscularis, Hypoplasia | | 4 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Edema | | 1 4.0|
Erosion | 3 | 2 3.5|
Inflammation, Suppurative | | 2 3.0|
Mineralization | | 1 4.0|
Serosa, Fibrosis | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 101
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 4| 6| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 5| 3| 6| 5| 3| 1| 3| 1| 3| | |
| 0| 8| 0| 0| 3| 0| 2| 0| 9| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.2_PPM | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| | L |
| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Tooth | | 1 |
Inflammation, Suppurative | | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 2 |
Atherosclerosis, Diffuse | | 1 |
Mineralization, Diffuse | | 1 4.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy | 1 2 2 1 | 19 1.7|
Mineralization | | 1 4.0|
Thrombosis | | 3 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Cytomegaly | 1 1 | 10 2.1|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 59 |
Hyperplasia | 2 3 2 2 | 13 2.5|
Bilateral, Hyperplasia | | 6 3.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + M | 56 |
Hyperplasia | | 4 2.3|
__________________________________________________________________________|____________|
Pituitary Gland | + M + + + + + + + + | 59 |
Cyst | | 3 |
Hemorrhage | | 1 4.0|
Pars Distalis, Hyperplasia | 3 | 6 2.7|
Pars Intermedia, Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Ultimobranchial Cyst | | 3 |
C-Cell, Hyperplasia | 3 | 8 1.9|
Follicular Cell, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 58 |
Cyst | | 4 |
Inflammation, Suppurative | 4 | 3 2.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 102
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 4| 6| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 5| 3| 6| 5| 3| 1| 3| 1| 3| | |
| 0| 8| 0| 0| 3| 0| 2| 0| 9| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.2_PPM | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| | L |
| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 60 |
Inflammation, Suppurative | 2 | 13 2.5|
Epithelium, Hyperplasia | 2 | 3 1.3|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
Inflammation, Suppurative | | 5 1.2|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Arteriole, Inflammation | | 5 3.2|
Interstitial Cell, Hyperplasia | 2 3 2 | 11 2.0|
Seminiferous Tubule, Atrophy | 4 3 | 12 3.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Myelofibrosis | | 4 2.3|
__________________________________________________________________________|____________|
Lymph Node | + | 8 |
Renal, Hyperplasia, Lymphoid | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M + + M + + + + + | 52 |
Pigmentation | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 60 |
Hemorrhage | | 1 3.0|
Hyperplasia, Lymphoid | 3 | 3 3.3|
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 60 |
Hemorrhage | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + | 58 |
Pigmentation | 3 | 3 2.3|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Ectopic Tissue | | 3 |
Fibrosis | | 7 2.4|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
Galactocele | | 2 |
Hyperplasia | 4 | 3 3.0|
Inflammation, Suppurative | | 3 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Abscess | | 1 2.0|
Cyst Epithelial Inclusion | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 103
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 4| 6| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 5| 3| 6| 5| 3| 1| 3| 1| 3| | |
| 0| 8| 0| 0| 3| 0| 2| 0| 9| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.2_PPM | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| | L |
| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
Mineralization | | 1 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Compression | X | 8 |
Hemorrhage | | 6 2.2|
Hydrocephalus | 3 | 4 2.5|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 59 |
Inflammation, Chronic | | 1 1.0|
Inflammation, Suppurative | | 4 1.8|
Metaplasia, Squamous | | 4 1.5|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Alveolar Epithelium, Hyperplasia | | 4 2.5|
Alveolus, Hemorrhage | 1 1 2 | 22 1.7|
Alveolus, Infiltration Cellular, | | |
Multifocal, Histiocyte | 2 4 | 15 3.0|
Alveolus, Inflammation, Suppurative | | 1 2.0|
Artery, Mineralization | | 2 3.0|
Bronchiole, Pigmentation | 1 2 1 1 1 2 1 2 1 2 | 59 1.4|
Peribronchiolar, Pigmentation | 2 1 1 | 20 1.5|
Pleura, Fibrosis | | 1 4.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Foreign Body | 2 3 | 7 2.7|
Hemorrhage | 2 | 9 2.6|
Inflammation, Suppurative | 2 3 3 2 | 13 2.3|
Pigmentation | 2 2 2 2 1 2 1 2 1 2 | 55 1.7|
Nasolacrimal Duct, Hemorrhage | 2 | 6 2.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 2 2.0|
Respiratory Epithelium, Hyperplasia | 3 1 3 2 1 | 15 2.0|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 2 2 | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 104
NTP Experiment-Test: 05114-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:57:54
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 4| 6| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 5| 3| 6| 5| 3| 1| 3| 1| 3| | |
| 0| 8| 0| 0| 3| 0| 2| 0| 9| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.2_PPM | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| | L |
| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
Pigmentation | | 5 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 2 |
__________________________________________________________________________|____________|
Eye | | 7 |
Cataract | | 2 2.0|
Anterior Chamber, Hemorrhage | | 1 2.0|
Choroid, Iris, Inflammation, Chronic | | 1 3.0|
Cornea, Inflammation | | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Cyst | | 1 |
Mineralization | | 2 1.5|
Nephropathy, Chronic | 3 2 4 2 3 4 4 3 4 3 | 59 2.9|
Pelvis, Dilatation | | 1 2.0|
Pelvis, Transitional Epithelium, | | |
Hyperplasia | | 1 3.0|
Renal Tubule, Hyperplasia | | 2 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
Inflammation, Suppurative | | 1 2.0|
Transitional Epithelium, Hyperplasia | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
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