National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/14836

Target Organs and Levels of Evidence for TR-494

Toxicology and Carcinogenesis Studies of Anthraquinone (CASRN 84-65-1) in F344/N Rats and B6C3F1 Mice (Feed Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Anthraquinone
84-65-1
12/09/2004Intermediate in manufacture of dyes and other organics. Organic inhibitor. Catalyst. Accelerator in nickel electroplating. Improving adhesion and heat stability of tire cord. (NTP executive summary). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Dosed-Feed
R: 0, 469, 938, 1875, OR 3750 PPM M: 0, 833, 2500, OR 7500 PPM
Battelle Columbus Laboratory

Levels of Evidence

Male Rats: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Kidney Tubular Cell: ADENOMA 1/50 3/50 9/50 5/50 3/50
  • Kidney Transitional Cell: PAPILLOMA 0/50 0/50 2/50 0/50 1/50
  • Urinary Bladder: TRANSITIONAL EPITHELIAL PAPILLOMA 0/50 1/50 3/50 7/50 3/49
May Have Been Related
  • Liver: ADENOMA OR CARCINOMA 1/50 3/50 4/50 5/50 3/50
Non-Neoplastic Lesions
  • KIDNEY: HYALINE DROPLET ACCUMULATION; INCREASED SEVERITY OF NEPHROPATHY; PIGMENTATION; MEDULLA MINERALIZATION; TRANSITIONAL EPITHELIAL HYPERPLASIA
  • LIVER: CENTRILOBULAR HYPERTROPHY; CYSTIC DEGENERATION; INFLAMMATION; EOSINOPHILIC FOCUS; MIXED CELL FOCUS; CYTOPLASMIC VACUOLIZATION
  • SPLEEN: CONGESTION; PIGMENTATION; HEMATOPOIETIC CELL PROLIFERATION
  • BONE MARROW: HYPERPLASIA
Other Considerations
  • HEMATOPOIETIC SYSTEM: MONONUCLEAR CELL LEUKEMIA 25/50 2/50 1/50 5/50 7/50
Female Rats: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Kidney Tubular Cell: ADENOMA 0/50 4/50 9/50 7/50 12/49; ADENOMA OR CARCINOMA 0/50 6/50 9/50 8/50 14/49
  • Urinary Bladder: TRANSITIONAL EPITHELIAL PAPILLOMA OR CARCINOMA 0/49 0/49 0/49 1/50 2/49
  • Liver: ADENOMA 0/50 2/50 6/50 4/50 3/50
Non-Neoplastic Lesions
  • KIDNEY: HYALINE DROPLET ACCUMULATION; NEPHROPATHY; PIGMENTATION; MEDULLA MINERALIZATION; TUBULAR CELL HYPERPLASIA; TRANSITIONAL EPITHELIAL HYPERPLASIA
  • LIVER: CENTRILOBULAR HYPERTROPHY; CYSTIC DEGENERATION; INFLAMMATION; EOSINOPHILIC FOCUS; MIXED CELL FOCUS; ANGIECTASIS
  • SPLEEN: CONGESTION; PIGMENTATION; HEMATOPOIETIC CELL PROLIFERATION
  • BONE MARROW: HYPERPLASIA; ATROPHY
Other Considerations
  • HEMATOPOIETIC SYSTEM: MONONUCLEAR CELL LEUKEMIA 18/50 1/50 1/50 2/50 0/50
Male Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 21/50 32/50 38/50 41/49 OR CARCINOMA 8/50 13/50 17/50 21/49 OR HEPATOBLASTOMA 1/50 6/50 11/50 37/49 COMBINED 26/50 35/50 43/50 48/49
May Have Been Related
  • Thyroid Gland Follicular Cell: ADENOMA 0/50 0/50 2/49 2/46
Non-Neoplastic Lesions
  • LIVER: CENTRILOBULAR HYPERTROPHY; FOCAL DEGENERATION; HEPATOCYTE ERYTHROPHAGOCYTOSIS; EOSINOPHILIC FOCUS; FOCAL NECROSIS
  • URINARY BLADDER: INTRACYTOPLASMIC INCLUSION BODY
  • THYROID GLAND: FOLLICULAR CELL HYPERPLASIA
  • SPLEEN: HEMATOPOIETIC CELL PROLIFERATION
  • KIDNEY: PIGMENTATION
Female Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 6/49 28/50 27/50 40/49 OR CARCINOMA 2/49 3/50 8/50 8/49 COMBINED 6/49 30/50 30/50 41/49
May Have Been Related
  • Thyroid Gland Follicular Cell: ADENOMA 1/45 1/48 2/48 2/48 OR CARCINOMA 0/45 0/48 0/48 2/48 COMBINED 1/45 1/48 2/48 4/48
Non-Neoplastic Lesions
  • LIVER: CENTRILOBULAR HYPERTROPHY; FOCAL DEGENERATION; EOSINOPHILIC FOCUS
  • URINARY BLADDER: INTRACYTOPLASMIC INCLUSION BODY
  • SPLEEN: HEMATOPOIETIC CELL PROLIFERATION


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