https://ntp.niehs.nih.gov/go/9834

Target Organs and Levels of Evidence for TR-527

Toxicology and Carcinogenesis Studies of Malachite Green Chloride and Leucomalachite Green (CASRNs 569-64-2 and 129-73-7) in F344/N Rats and B6C3F1 Mice (Feed Studies)

Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
Leucomalachite green
129-73-7		 02/17/2004 Dosed-Feed
R: 0, 91, 272, OR 543 PPM M: 0, 91, 204, OR 408 PPM		 National Center for Toxicological Research

Levels of Evidence

Male Rats: Equivocal Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Thyroid Gland Follicular Cell: ADENOMA OR CARCINOMA 0/47 2/47 1/48 3/46
  • Testis: INTERSTITIAL CELL ADENOMA 37/48 42/47 43/48 45/47 BILATERAL INTERSTITIAL CELL ADEMONA 22/48 30/47 38/48 39/47
Non-Neoplastic Lesions
  • THYROID GLAND: FOLLICLE CYST
  • LIVER: EOSINOPHILIC FOCUS; CYSTIC DEGENERATION
Other Considerations
  • MONONUCLEAR CELL LEUKEMIA: 29/48 16/47 19/48 7/47
  • PITUITARY GLAND: ADENOMA 30/45 19/46 21/48 13/45
Female Rats: Equivocal Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Thyroid Gland Follicular Cell: CARCINOMA OR ADENOMA 0/46 1/46 2/47 1/48
  • Liver: HEPATOCELLULAR ADENOMA 1/48 3/48 0/48 3/48
Non-Neoplastic Lesions
  • THYROID GLAND: FOLLICLE CYST
  • LIVER: EOSINOPHILIC FOCUS; VACUOLIZATION CYTOPLASMIC
Other Considerations
  • MONONUCLEAR CELL LEUKEMIA: 17/48 8/48 5/48 8/48
Female Mice: Some Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA OR CARCINOMA 3/47 6/48 6/47 11/47
Non-Neoplastic Lesions
  • URINARY BLADDER: INCLUSION BODY INTRACYTOPLASMIC
 
Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
Malachite green
569-64-2		 02/17/2004 Dosed-Feed
R: 0, 100, 300, OR 600 PPM M: 0, 100, 225, OR 450 PPM		 National Center for Toxicological Research

Levels of Evidence

Female Rats: Equivocal Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Thyroid Gland Follicular Cell: ADENOMA OR CARCINOMA 0/46 0/48 3/47 2/46
  • Liver: ADENOMA 1/48 1/48 3/48 4/48
  • Mammary Gland: CARCINOMA 2/48 2/48 1/48 5/48
Non-Neoplastic Lesions
  • THYROID GLAND: FOLLICLE CYST
  • LIVER: EOSINOPHILIC FOCUS
Other Considerations
  • MONONUCLEAR CELL LEUKEMIA: 19/48 17/48 10/48 1/48
Female Mice: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • URINARY BLADDER: INCLUSION BODY CYTOPLASMIC