National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/sa-39

Chemicals Associated with Site-Specific Tumor Induction in Mammary Gland

Chemicals Associated with Site-Specific Tumor Induction in Mammary Gland
 Levels of Evidence of Carcinogenicity May Have Been Related
TRChemicalSalmonella ResultsRouteMale RatsFemale RatsMale MiceFemale MiceSex/SpeciesMultiple Tumor Sites
TR-049Acronycine Intraperitoneal InjectionP(P)ISIS    Yes
TR-575Acrylamide-,W+Dosed-WaterCE(CE)CE(CE)    Yes
TR-289Benzene-GavageCECECE(CE)    Yes
TR-4522,2-bis(Bromomethyl)-1,3-propanediol+,+,-Dosed-Feed(CE)(CE)CECE   (FM)Yes
TR-2881,3-Butadiene+Inhalation  CE(CE)    Yes
TR-4341,3-Butadiene+Inhalation  CE(CE)    Yes
TR-3792-Chloroacetophenone (CN)-InhalationNE(EE)NENE    No
TR-467Chloroprene-InhalationCE(CE)CE(CE)    Yes
TR-405C.I. Acid red 114+Dosed-WaterCECE   (FR)  Yes
TR-285C.I. Basic red 9 monohydrochloride+Dosed-FeedCECECECE (FR)  Yes
TR-091Clonitralid Dosed-FeedN(E)ISN    Yes
TR-207Cytembena+Intraperitoneal InjectionP(P)NN    Yes
TR-1622,4-Diaminotoluene (2,4-toluene diamine)+Dosed-FeedP(P)NP    Yes
TR-0281,2-Dibromo-3-chloropropane+GavageP(P)PP    Yes
TR-2101,2-Dibromoethane+InhalationP(P)P(P)    Yes
TR-4002,3-Dibromo-1-propanol+Topical ApplicationCE(CE)CECE    Yes
TR-0661,1-Dichloroethane-GavageN(E)NE    Yes
TR-0551,2-Dichloroethane+GavageP(P)P(P)    Yes
TR-2631,2-Dichloropropane (propylene dichloride)W+,W+GavageNE(EE)SESE    Yes
TR-342Dichlorvos+GavageSE(EE)SECE    Yes
TR-3723,3'-Dimethoxybenzidine dihydrochloride Dosed-WaterCE(CE)      Yes
TR-3903,3'-Dimethylbenzidine dihydrochloride+Dosed-WaterCE(CE)      Yes
TR-0542,4-Dinitrotoluene+Dosed-FeedP(P)NN    Yes
TR-548Endocrine disruptor (Ethinyl estradiol)
(F3T21)
 Dosed-FeedEEEE  (MR)   Yes
TR-545Endocrine disruptor (Genistein) Dosed-Feed     (FR)   
TR-326Ethylene oxide Inhalation  CE(CE)    Yes
TR-356Furosemide-,-Dosed-FeedEENENE(SE)    Yes
TR-374Glycidol+,+Gavage(CE)(CE)CE(CE)    Yes
TR-092Hydrazobenzene+Dosed-FeedP(P)NP    Yes
TR-499Indium phosphide InhalationCECECECE (FR)  Yes
TR-551Isoeugenol-,-GavageEENECEEE(MR)   Yes
TR-032Isophosphamide Intraperitoneal InjectionN(P)NP    Yes
TR-486Isoprene-Inhalation(CE)(SE)      Yes
TR-527Malachite green-Dosed-Feed (EE) NE    Yes
TR-306Methylene chloride+,+,-Inhalation(SE)(CE)CECE    Yes
TR-491Methyleugenol-Gavage(CE)CECECE    Yes
TR-146Nithiazide+Dosed-FeedN(P)PE    Yes
TR-1185-Nitroacenaphthene+Dosed-FeedP(P)NP    Yes
TR-337Nitrofurazone+Dosed-FeedEE(CE)NECE    Yes
TR-461Nitromethane-InhalationNE(CE)CECE    Yes
TR-504o-Nitrotoluene-,-Dosed-Feed(CE)(CE)CECE    Yes
TR-358Ochratoxin A-GavageCE(CE)      Yes
TR-060Phenesterin-,-GavageN(P)PP    Yes
TR-019Procarbazine hydrochloride-Intraperitoneal Injection(P)(P)PP    Yes
TR-193Reserpine-Dosed-FeedPNP(P)    Yes
TR-115Sulfallate+Dosed-FeedP(P)P(P)    Yes
TR-2512,4- & 2,6-Toluene diisocyanate+GavageP(P)NP    Yes
TR-153o-Toluidine hydrochloride+,-Dosed-FeedP(P)PP    Yes
TR-3841,2,3-Trichloropropane+,+GavageCE(CE)CECE    Yes
TR-510Urethane+,EDosed-Water  CE(CE)    Yes
TR-510Urethane + ethanol (combination) Dosed-Water  CE(CE)    Yes
TR-549Water disinfection byproducts (Bromochloroacetic acid) Dosed-WaterCE(CE)CECE    Yes
TR-583Water disinfection byproducts (Bromodichloroacetic acid) Dosed-WaterCE(CE)CECE    Yes
 Totals942015 
The number of chemicals causing tumors in Mammary Gland is 52.

Levels of Evidence of Carcinogenicity: CE or P = Clear Evidence, SE = Some Evidence, EE or E = Equivocal Evidence, NE or N = No Evidence, IS = Inadequate Experiment

Salmonella Results: + = Positive, +W = Weakly Positive, ? = Inconclusive, - = Negative

Parentheses indicate the animal group in which a tumor occurred in the organ specified.

Sex/Species: MR = Male Rats, FR = Female Rats, MM = Male Mice, FM = Female Mice

Totals include positive, equivocal and may-have-been-related responses where a tumor occurred in the organ specified.

NOTE: Blank space under the animal groups indicates no experiments were done.

NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.