The nomination and selection for study of chemicals and other substances with the highest potential for adversely impacting public health are essential to the success of the program. From its inception, NTP has had an open nomination process. Nominations are solicited from sources in academia, federal and state regulatory and health agencies, industry, and unions, as well as from advocacy groups and the general public. Particular assistance is sought with the selection of studies that address issues such as testing of hypotheses to enhance the predictive ability of NTP studies, mechanisms of toxicity, or filling significant gaps in knowledge of the toxicity of chemicals or classes of chemicals.
Substances are studied for a variety of health-related effects, including but not limited to, reproductive and developmental toxicity, genotoxicity, immunotoxicity, metabolism and disposition, and carcinogenicity. The possible public health consequences of exposure remain the over-riding factor in the decision to study a particular substance. Selections for government testing are based on the principle that responsible industries will evaluate their own products for health and environmental effects as mandated by Congress under legislative authorities. Nominations to NTP should be based on one or more of the principles listed below.
NTP is an interagency program whose mission is to evaluate chemical, biological, and physical agents (collectively referred to as "substances") of public health concern by developing and applying tools of modern toxicology and molecular biology. NTP operates under the general principle that industry will evaluate substances for health and environmental effects as intended and mandated by Congress under legislative authorities. Therefore NTP, acting to carry out its mission, solicits nominations for NTP studies from the following categories:
Prior to committing to specific studies, NTP assesses the needs for studies by: evaluating existing literature and testing data, assessing ongoing evaluations in the government and private sector, and determining how the nomination fits into an overall plan for improving current test methods. The selection of a substance or issue for study by NTP does not automatically commit NTP to its evaluation. NTP considers priorities for nominated studies at many phases: when the nomination is reviewed and evaluated for possible study, when the study is being designed, and again when NTP considers the most appropriate intramural or extramural mechanism to conduct the study. NTP may defer a study during any of these phases if suitable data become available, if higher priority studies are identified, or if the study proves to be impractical.
Nominations should be addressed to:
Nominations may also be submitted using the Online Nomination Form.
Member agencies of the National Toxicology Program (FDA, NIEHS, and NIOSH) and other sources (including other federal agencies, state agencies, the public, labor, and industry) submit nominations of substances and issues to NTP for toxicological testing.
All nominating sources are asked to identify when possible: the particular toxicological information needed; the rationale for the nomination; any available background data on production, use, exposure, environmental occurrence; and the extent of available toxicological information (see "Nomination Elements" below). However, it is recognized that all potential nomination sources do not have the resources to obtain all the requested information. Therefore, all nominations are considered regardless of the extent of the information submitted.