National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10022-h

Hydroquinone - 10022-H

CASRN: 123-31-9

Formula: C6-H6-O2

Synonyms/Common Names:

  • 1,4-BENZENEDIOL (9CI)

Known Uses:

Photographic developer. In manufacture of dyes, rubber antioxidants. Polymerization inhibitor, stabilizer. In skin-lightening creams; hair dyes. Found in coal tar effluent. An antioxidant in the rubber industry & as a developing agent in photography. Also an intermediate in the manufacture of rubber & food antioxidants & monomer inhibitors. Used as depigmenting agents to lighten skin. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Nomination Background

Short-Term Toxicity

  • 13-Week (Gavage)  (C55834B)  Completed 
    • Rats: F344/N; Mice: B6C3F1

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C55834B)  Report Complete 
    • TR-366 (NIH Number: 89-2821; NTIS Number: PB90-240839)  (Peer Review Approval 10/03/1988A )
      Toxicology and Carcinogenesis Studies of Hydroquinone (CASRN 123-31-9) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Some Evidence 
      • Female Rats Some Evidence 
      • Male Mice No Evidence 
      • Female Mice Some Evidence 
    • Dose: R: 0,25,50, M: 0,50,100 MG/KG/65 PER GROUP.

Modified One-Generation

  • Dose Range Finding  (MOG10022)   
    • Developmental Toxicity (Gavage) Selected (MOG10022B)  
      • Rats: Harlan Sprague-Dawley
    • F0 Generation (Gavage) Selected (MOG10022B)  
      • Rats: Harlan Sprague-Dawley
    • Fertility Assessment (Gavage) Selected (MOG10022B)  
      • Rats: Harlan Sprague-Dawley
    • Neurotoxicology Assessment (Gavage)  (MOG10022B)   
      • Rats: Harlan Sprague-Dawley

    Special Studies

    • Absorption Disposition Metabolism Elimination (Gavage; Intravenous; Topical Application)  (K10022)  On Test 
      • Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1; Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1; Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1

    Genetic Toxicology

    • In Vitro Cytogenetics (CA/SCE)  (886668)  Completed 
      • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
      • Sister Chromatid Exchange Positive 
      • Chromosome Aberrations Positive 
    • Drosophila  (814626)  Completed 
      • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63
      • Reciprocal Translocation/Sex-Linked Recessive Lethal Equivocal 
    • Mouse Lymphoma  (327913)  Completed 
      • Citation: McGregor, D.B., Brown, A., Cattanach, P., Edwards, I., McBride, D., and Caspary, W.J. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay to coded chemicals. II. 18 coded chemicals. Environ. Molec. Mutagen. Vol. 11 (1988) 91-118
      • Mice
      •  Positive 
    • Micronucleus  (A06686)  Completed 
      • Mice: B6C3F1
      • Male Positive 
    • Salmonella  (296791)  Completed 
      • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
      •  Negative 
    The NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.