National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10105-j

Turmeric, oleoresin (curcumin) - 10105-J

CASRN: 8024-37-1

Related: CURCURMIN (458-37-7)

Formula: C21-H20-O6

Synonyms/Common Names:

  • CURCUMA LONGA OILS
  • CURCUMA OIL
  • Curcumin
  • TURMERIC OIL

Known Uses:

Condiment. Color for ointments.

Short-Term Toxicity

  • 13-Week (Dosed-Feed)  (C60015)  Completed 
    • Rats: F344/N; Mice: B6C3F1

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C60015)  Report Complete 
    • TR-427 (NIH Number: 93-3158; NTIS Number: PB94-184173)  (Peer Review Approval 06/23/1992A )
      Toxicology and Carcinogenesis Studies of Turmeric Oleoresin (CASRN 8024-37-1) (Major Component 79% Curcumin, CASRN 458-37-7) in F344/N Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats Equivocal Evidence 
      • Male Mice Equivocal Evidence 
      • Female Mice Equivocal Evidence 
    • Dose: R & M: 0, .2, 1.0, AND 5.0%.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (001566)  Completed 
    • Sister Chromatid Exchange Weakly Positive 
    • Chromosome Aberrations Weakly Positive 
  • Salmonella  (857432)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 

Organ Systems Toxicity

  • Continuous Breeding (Legacy) (Dosed-Feed)  (RACB85001)  Completed 
    • Male and Female Rats/Mice: F344/N & B6C3F1
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