National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10170-v

Tetrahydrofuran - 10170-V

CASRN: 109-99-9

Formula: C4-H8-O

Synonyms/Common Names:

  • 1,4-EPOXYBUTANE

Known Uses:

Reaction medium for grignard and metal hydride reactions. Packaging fabrication. Solvent for resins and plastics. Chemical intermediate. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Short-Term Toxicity

  • 14-Day (Gavage)  (C60560A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C60560A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13 weeks (Inhalation)  (C60560B)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0,66,200,600,1800,5000 PPM.

Long-Term Carcinogenicity

  • 2 years (Inhalation)  (C60560C)  Report Complete 
    • TR-475 (NIH Number: 98-3965; NTIS Number: PB98-164544)  (Peer Review Approval 12/11/1996A )
      Toxicology and Carcinogenesis Studies of Tetrahydrofuran (CASRN 109-99-9) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Some Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice Clear Evidence 
    • Dose: R&M: 0, 200, 600, OR 1800 PPM (50/SEX/SPECIES/GROUP).

Genetic Toxicology

  • Chromosome Aberrations  (720076)  Completed 
    • Mice
    •  Negative 
  • In Vitro Cytogenetics (CA/SCE)  (378945)  Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Drosophila  (442740)  Completed 
    • Citation: Valencia, R., Mason, J.M., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: III. Results of 48 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 325-348
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Micronucleus  (A34612)  Completed 
    • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
    • Mice: B6C3F1
    • Male Equivocal 
    • Female Negative 
  • Salmonella  (551903)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 
  • Salmonella  (620162)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 
  • Sister Chromatid Exchanges  (720076)  Completed 
    • Mice
    • Sister Chromatid  Positive (Nonstandard Protocol) 

Organ Systems Toxicity

  • 6 to 17 GD for mice Conventional Teratology (Inhalation)  (TER88047)  Completed 
    • NTIS Number: DE89001383
      Citation: Inhalation Developmental Toxicology Studies: Teratology Study of Tetrahydrofuran in Mice and Rats (August 1988)
    • Female Rats/Mice: Sprague Dawley/Swiss
    • Rats/Mice Maternal Positive 
    • Rats/Mice Fetal Positive 
    • Dose: 600, 1800, 5000 PPM.
  • 6 to 19 days GD Conventional Teratology (Inhalation)  (TER88139)  Completed 
    • NTIS Number: DE89001383
      Citation: Inhalation Developmental Toxicology Studies: Teratology Study of Tetrahydrofuran in Mice and Rats (August 1988)
    • Female Rats: Sprague Dawley
    • Dose: 0, 600, 1800, 5000 PPM.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.