National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10477-n

5-Nitro-o-anisidine - 10477-N

CASRN: 99-59-2

Formula: C7-H8-N2-O3

Synonyms/Common Names:

  • 2-METHOXY-5-NITROBENZENAMINE (9CI)

Known Uses:

Dye intermediate

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C01934)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C01934)  Completed 
    • Rats: F344/N; Mice: B6C3F1

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C01934)  Report Complete 
    • TR-127 (NIH Number: 78-1382; NTIS Number: PB287411)  (Peer Review Approval 06/29/1978A )
      Bioassay of 5-Nitro-o-anisidine for Possible Carcinogenicity (CASRN 99-59-2)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Positive 
      • Female Rats Positive 
      • Male Mice Equivocal 
      • Female Mice Positive 

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (509998)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Drosophila  (168140)  Completed 
    • Citation: Valencia, R., Mason, J.M., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: III. Results of 48 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 325-348
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Drosophila  (241914)  Completed 
    • Citation: Zimmering, S., Mason, J.M., and Valencia, R. Chemical mutagenesis testing in Drosophila. VII. Results of 22 coded compounds tested in larval feeding experiments. Environ. Molec. Mutagen. Vol. 14 (1989) 245-252
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Positive 
  • Drosophila  (313175)  Completed 
    • Citation: Valencia, R., Mason, J.M., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: III. Results of 48 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 325-348
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Positive 
  • Salmonella  (116557)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Positive 
The NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.