National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10890-x

4,4'-Sulfonyldianiline (Dapsone) - 10890-X

CASRN: 80-08-0

Formula: C12-H12-N2-O2-S

Synonyms/Common Names:

  • DAPSONE
  • DAPSONE (AIDS)
  • 4,4'-SULFONYBISBENZENAMINE (9CI)

Known Uses:

Hardening agent for epoxy resins; topical antibacterial agent; treatment of gynecologic neoplasms; antibacterial/antiprotozoal in veterinary medicine, used in treatment of leprosy

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C01718)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C01718)  Completed 
    • Rats: F344/N; Mice: B6C3F1

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C01718)  Report Complete 
    • TR-020 (NIH Number: 77-820; NTIS Number: PB274394)  (Peer Review Approval 07/25/1977A )
      Bioassay of Dapsone for Possible Carcinogenicity (CASRN 80-08-0)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Positive 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (954704)  Completed 
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Weakly Positive 
  • In Vitro Cytogenetics (CA/SCE)  (962654)  Completed 
    • Sister Chromatid Exchange Not a Valid Test 
    • Chromosome Aberrations Weakly Positive 
  • Mouse Lymphoma  (001410)  Completed 
    • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
    • Mice
    •  Negative 
  • Salmonella (NCI)  (CV-204)  Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248
    • Salmonella
    • Salmonella-NCI  Negative 
  • Salmonella  (318705)  Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 

Organ Systems Toxicity

  • Immunotoxicity (Gavage)  (IMM90015)  Completed 
  • 1 to 31 Repro/Dev Gen Tox (28-Day) (Gavage)  (RACB93157)  Completed 
    • Male and Female Mice: Swiss
    • Dose: N/A; N/A; N/A; N/A.
The NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.