National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-9002895

Polyvinyl alcohol - 9002895

 

CASRN: 9002-89-5

Formula: (C2-H4-O)x-

Synonyms/Common Names

  • HOMOPOLYMER ETHANOL (9CI)
  • VINYL ALCOHOL, POLYMERS (8CI)

Known Uses

PVA film for intravaginal administration of spermicides. Textile warp sizing and finishing. Adhesives. Pesticides. Pigment in TV picture tubes.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 4 weeks (Intravaginal)  (C88066)  Completed 
    • Mice: B6C3F1
    • Dose: 0, 20 UL OF 25% PVA - NO RESTRAINT, 20 UL OF 25% PVA WITH RESTRAINT; 50/GROUP.

Long-Term Carcinogenicity

  • 2 years (Intravaginal)  (C88066)  Report Complete 
    • TR-474 (NIH Number: 98-3964; NTIS Number: PB98-148869)  (Peer Review Approval 12/12/1996A )
      Toxicology and Carcinogenesis Studies of Polyvinyl Alcohol (CASRN 9002-89-5) in Female B6C3F1 Mice (Intravaginal Studies)
    • Mice: B6C3F1
    • Carcinogenesis Results
      • Female Mice No Evidence 
    • Dose: 25% PVA, VEHICLE, UNTREATED; 100/GROUP.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intravaginal; Intravenous)  (S0695)  Completed 
    • Citation: Sanders JM, Matthews HB. Vaginal absorption of polyvinyl alcohol in Fischer 344 rats. Hum Exp Toxicol. 1990 Mar;9(2):71-7.Pubmed Abstract
    • Male Rats: F344/N; Female Rats: F344/N; Male Rats: F344/N
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