National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m200033

Tetrabromobisphenol A - M200033

CASRN: 79-94-7

Formula: C15-H12-Br4-O2

Synonyms/Common Names:

  • PHENOL, 4,4'-(1-METHYLETHYLIDENE)BIS(2,6-DIBROMO (9CI)
  • TBBPA

Known Uses:

Flame retardant for plastics, paper, and textiles.

Nomination Background

Short-Term Toxicity

  • 13 weeks (Gavage)  (C20033)  Completed 
    • Toxicogenomics
    • Rats: Wistar Han
    • Dose: 0, 23, 250, or 1000 mg/kg.
  • 13 weeks (Gavage)  (C20320)  Completed 
    • Rats: F344/NTac; Mice: B6C3F1
    • Dose: R&M: 0, 10, 50, 100, 500, OR 1000 MG/KG; R: 20/SEX/DOSE; M: 10/SEX/DOSE.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C20320)  Report Draft 
    • TR-587   (Peer Review Approval 10/29/2013A )
      Toxicology and Carcinogenesis Studies of Tetrabromobisphenol A (CASRN 79-94-7) in F344/NTac Rats and B6C3F1/N Mice (Gavage Studies)
    • Rats: Wistar Han; Mice: B6C3F1
    • Dose: R&M: 0, 250, 500, OR 1000 MG/KG; 50/SEX/SPECIES/DOSE.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous)  (S0897)  Completed 
    • Citation: Chemical Disposition in Mammals. FINAL REPORT ON: TETRABROMOBISPHENOL A (TBBPA). October 1, 2004 - December 31, 2004.
    • Male Rats: F344/N

Genetic Toxicology

  • Micronucleus  (A13260)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (968573)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 
  • Salmonella  (G20033)  Completed 
    •  Negative 

Toxicogenomics

  • Microarray Analysis (Gavage) Selected (T20033)  
    • Microarray and RT-PCR
    • Rats: Wistar Han
The NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.