National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m910070

Perfluorooctanoic Acid - M910070

CASRN: 335-67-1

Formula: C8-H-F15-O2

Synonyms/Common Names:

  • C8 CARBOXYLIC ACID
  • PENTADECAFLUOROOCTANOIC ACID (9CI)
  • PFOA

Known Uses:

Chemical used in production of fluoropolymers which impart properties of stain, oil, or water resistance in products.

Nomination Background

Short-Term Toxicity

  • 28 days (Gavage)  (C91070B)  On Test 
    • Rats: Harlan Sprague-Dawley
    • Dose: Males: 0, 0.625, 1.25, 2.5, 5, or 10 mg/kg; Females: 0, 6.25, 12.5, 25, 50, or 100 mg/kg.
  • 4 days (Gavage)  (C91070)  On Test 
    • Liver Targeted Testing study of Toxcast Chemicals
    • Rats: Harlan Sprague-Dawley
    • Dose: Male mice: 0, 15, 180 mg/kg/day.

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C20614B)  Histopath in progress 
    • Rats: Harlan Sprague-Dawley
    • Dose: MR: 0, 20, 40, 80, 300/0, 300/20, 300/40, or 300/80 ppm.
  • 2 years (Dosed-Feed)  (C20614)  Histopath in progress 
    • Rats: Harlan Sprague-Dawley
    • Dose: FR: 0, 300, OR 1000 PPM; MR: 0, 150, OR 300; 60/SEX.

Modified One-Generation

  • Dose Range Finding (Gavage)  (MOG91070)  Completed 
    • Dose Range Finding
    • Rats: Harlan Sprague-Dawley; Mice: CD-1 Reg.[Crl:CD1(ICR)]

Special Studies

  • Cell Proliferation (Gavage)  (S0174)  Completed 
    • Citation: Thottassery J, Winberg L, Youssef J, Cunningham M, Badr M. Regulation of perfluorooctanoic acid-induced peroxisomal enzyme activities and hepatocellular growth by adrenal hormones. Hepatology. 1992 Feb;15(2):316-22.
    • Male Rats: Sprague Dawley

Genetic Toxicology

  • Micronucleus  (G91070)  Completed 
    • Rats: Harlan Sprague-Dawley
    • Male Positive 
    • Female Negative 
  • Salmonella  (A98283)  Completed 
    •  Equivocal 

Organ Systems Toxicity

  • 6 GD to PND 21 Conventional Teratology (Gavage) Selected (R91070)  
    • Rats: Sprague Dawley

Toxicogenomics

  • 4 days Microarray Analysis (Gavage)  (T91070)  Completed 
    • Liver Targeted Testing study of Toxcast Chemicals
    • Rats: Harlan Sprague-Dawley
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