National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m970041

Toxic equivalency factor evaluation (PCB Mixture; PCB 126/PCB 118) - M970041

 

CASRN: TEFPCBMIX

Synonyms/Common Names

  • PCB Mixture (Toxic equivalency factor evaluation)
  • Toxic equivalency factor evaluation (PCB Mixture (PCB 126/PCB 118))

Secondary:

  • 31508-00-6 - 2,3',4,4',5-Pentachlorobiphenyl
  • 57465-28-8 - 3,3,4,4,5-Pentachlorobiphenyl (PCB 126)
  • 31508-00-6 - Toxic equivalency factor evaluation (PCB 118)
  • 57465-28-8 - TEF transgenics (PCB 126)
  • 57465-28-8 - Toxic equivalency factor evaluation ((PCB 126) 3,3',4,4',5-pentachlorobiphenyl)

Known Uses

One of 2 dioxin-like compounds plus mixtures being tested to determine if the TEFs for these chemicals would be predictive of rodent carcinogenicity. This mixture consists of PCB 118 (2,3',4,4',5- pentachlorobiphenyl) & PCB 126 (3,3',4,4',5- pentachlorobiphenyl) Mixtures were produced commercially before 1977 for the electric industry as dielectric insulating fluids for transformers & capacitors

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C96022)  Report Complete 
    • TR-531 (NIH Number: 07-4467; NTIS Number: PB2007-103748)  (Peer Review Approval 12/09/2004A )
      Toxicology and Carcinogenesis Studies of a Binary Mixture of 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) (CASRN 57465-28-8) and 2,3',4,4',5-Pentachlorobiphenyl (PCB 118) (CASRN 31508-00-6) in Female Harlan Sprague-Dawley Rats (Gavage Studies)
    • Rats: Harlan Sprague-Dawley
    • Carcinogenesis Results
      • Female Rats Clear Evidence 
    • Dose: Female rats only (PCB 118/PCB 126): 0, 7, 22, 72, 216, or 360 ng/kg; 50/dose.
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