NTP Logo

Annual Report for Fiscal Year 2015

Annual Report for Fiscal Year 2015
Menu
https://ntp.niehs.nih.gov/go/790015

Completed Technical Reports

The results of NTP studies undergo peer review and are published in NTP report series. Long-term toxicology and carcinogenicity studies, generally two-years in length, are reported in the NTP Technical Report (TR) series. Toxicity (TOX) reports are for shorter-term studies, generally up to 13 weeks. All peer reviewers are screened for conflict of interest prior to confirming their service. These reports are available on the NTP website and catalogued in PubMed.  

NTP TRs published in FY 2015 are listed in the table below. NTP used established criteria to evaluate the findings and determine the strength of the evidence for conclusions regarding the carcinogenic activity of each substance. The conclusions for level of evidence of carcinogenic activity are included in the table. The final reports are available on the NTP website.

NTP anticipates two draft TRs will undergo peer review in FY 2015, as listed in the second table below.

Technical Reports Published During FY 2015 Reporting Levels of Evidence of Carcinogenic Activity
Chemical Technical Report Number/ CASRN Use Male Rats
 
Female Rats
 
Male Mice
 
Female Mice
 
Cobalt TR-581
7440-48-4
 
Used in the production of alloys, in nuclear medicine, and as a catalyst in organic reactions. Exposure to cobalt metal dust occurs in a variety of metalworking occupations. Associated with tobacco either as a natural component of tobacco, pyrolysis product in tobacco smoke, or additive for one or more types of tobacco products. Clear evidence Clear evidence Clear evidence Clear evidence
CIMSTAR 3800 TR-586 Semisynthetic metal working fluid. Equivocal evidence Equivocal evidence No evidence Some evidence
Glycidamide TR-588
5694-00-8
 
Metabolite of acrylamide. Associated with tobacco either as a natural component of tobacco, pyrolysis product in tobacco smoke, or additive for one or more types of tobacco products. Clear evidence Clear evidence Clear evidence Clear evidence
Vinylidene chloride TR-582
75-35-4
 
Copolymerized with vinylchloride or acrylonitrile for saran and saran fibers. A widely used chemical intermediate and monomer. Clear evidence Some evidence Clear evidence Clear evidence

Technical Reports Expected to Undergo Peer Review in FY 2016
Chemical Technical Report Number/CASRN Use
Antimony trioxide TR-590
1309-64-4
 
Flame retardant in fabrics, resins, and wood coatings; pigment and additive for opacity in glass, ceramics, and plastic; chemical intermediate for potassium antimony tartrate; raw material for manufacture of antimony metal.
Trim® VX TR-591 Soluble oil and metalworking fluid.