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Annual Report for Fiscal Year 2015

Annual Report for Fiscal Year 2015


The Scientific Advisory Committee on Alternative Toxicological Methods (SACATM) is a federally chartered advisory committee established January 9, 2002, in response to the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) Authorization Act of 2000 (42 U.S.C. 285l-3(d)). SACATM advises ICCVAM, the NTP Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM), and the director of NIEHS and NTP regarding statutorily mandated duties of ICCVAM and activities of NICEATM. SACATM provides advice on priorities and activities related to the development, validation, scientific review, regulatory acceptance, implementation, and national and international harmonization of new, revised, and alternative toxicological test methods. The SACATM charter and current roster are available on the NTP website. The table below provides the roster for FY 2015. SACATM typically meets once a year and members serve rotating terms of up to four years. Lori White, Ph.D., serves as the designated federal officer and manager of SACATM.

SACATM met once during FY 2015 on September 2, 2015, at NIEHS. At the meeting, ICCVAM and NICEATM updated SACATM on the activities since the last meeting, including information on (1) in vitro to in vivo extrapolation, (2) fit-for-purpose validation, (3) integrated analysis of data, (4) endocrine disruptor testing, (5) skin sensitization testing, and (6) acute toxicity testing. ICCVAM members provided an update on international activities and metrics for quantifying animal usage. SACATM heard a proposal for creating a 3Rs (replacement, reduction, or refinement of animal use in testing and research) roadmap and strategy. SACATM provided input on the reports from four federal agencies: the U.S. Department of Agriculture, FDA, EPA, and NIEHS.

Members of SACATM, ICCVAM, and staff from NIEHS and NTP at the September 2015 SACATM meeting

NTP SACATM Membership Roster FY 2015

Name and Title Affiliation Term Ends
Lauren E. Black, Ph.D.
Senior Scientific Advisor
Navigators Services
Charles River Laboratories
Reno, Nevada
Tracie E. Bunton, D.V.M., Ph.D.
Eicarte LLC
Gettysburg, Pennsylvania
Joy Cavagnaro, Ph.D., D.A.B.T., R.A.C., A.T.S., R.A.P.S.
President and Founder
Access BIO LC
Boyce, Virginia
Joan M. Chapdelaine, Ph.D.
Senior Immunologist and Director, Business Development
Calvert Laboratories, Inc.
Scott Township, Pennsylvania
Mark G. Evans, D.V.M., Ph.D., A.C.V.P.
Research Fellow
La Jolla Laboratories
San Diego, California
William P. Janzen (Chair starting December 2014)
Executive Director of Lead Discovery
Epizyme, Inc.
Cambridge, Massachusetts
Michael D. Kastello, D.V.M., Ph.D.
Vice President and Global Head
Animal Research and Welfare
Disposition, Safety and Animal Research
Bridgewater, New Jersey 
Safdar A. Khan, D.V.M., M.S., Ph.D., D.A.B.V.T.
Associate Director
Global Pharmacoavigilance
Kalamazoo, Michigan
Ricardo Ochoa, D.V.M., Ph.D., A.C.V.P.
President and Principal
Pre-Clinical Safety, Inc.
Niantic, Connecticut
Catherine E. Willett, Ph.D.
Regulatory Toxicology, Risk Assessment and Alternatives
The Humane Society of the United States
Gaithersburg, Maryland
Daniel M. Wilson, Ph.D., D.A.B.T. (Chair)
Mammalian Toxicology Consultant
Toxicology and Environmental Research and Consulting
The Dow Chemical Company
Midland, Michigan
Wei Xu, Ph.D.
Associate Professor
Department of Oncology
McArdle Laboratory for Cancer Research
University of Wisconsin at Madison
Madison, Wisconsin