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Annual Report for Fiscal Year 2015

Annual Report for Fiscal Year 2015
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International Validation Activities

NICEATM and ICCVAM participate in international test method validation activities through the Organisation for Economic Co-operation and Development (OECD), and collaborate with countries that are members of the International Cooperation on Alternative Test Methods (ICATM), including the European Union, Japan, Korea, and Health Canada. ICATM collaborations address three critical areas of cooperation: test method validation studies, independent peer review of validation studies, and the development of formal recommendations on alternative testing methods.

In FY 2015, ICCVAM agencies commented on draft OECD documents through the U.S. National Coordinator for the OECD Test Guidelines Programme, who is an ex officio ICCVAM member. NICEATM and ICCVAM collaborated with international colleagues on drafting a proposal for a new test guideline describing an in vitro assay for measuring induction of human cytochrome P450. They are also participating in an OECD drafting group for a guidance document on integrated approaches to testing and assessment for skin sensitization. Representatives of NICEATM and ICCVAM attended a meeting of the drafting group in November 2014. 

The table below lists ongoing international validation studies led by ICATM member organizations that include NICEATM or ICCVAM participants. NICEATM and ICCVAM representatives attended an ICATM coordination meeting in June 2015 and attended a coordination meeting planned in November 2015.

Participation in International Validation Studies
Test Method Type of Test Lead Organization NICEATM-ICCVAM Involvement
IL-8 in vitro test for assessing skin sensitization potential Allergic contact dermatitis
 
JaCVAM*
 
NICEATM staff served on the validation management team and provided comments on study design, chemical selection, and test method protocols.
 
Vitrigel-SST assay for assessing skin sensitization potential
 
Allergic contact dermatitis
 
JaCVAM
 
NICEATM staff served on the validation management team.
 
Vitrigel-EIT assay for eye irritation testing
 
Ocular irritation
 
JaCVAM
 
NICEATM staff served on the validation management team.
 
Hand1-luc in vitro test for assessing reproductive toxicity potential
 
Reproductive toxicity
 
JaCVAM
 
NICEATM staff served on the validation management team.
 
SIRC-CVS assay for eye irritation testing
 
Ocular irritation
 
JaCVAM
 
NICEATM staff served on the validation management team.
 

*Japanese Center for the Validation of Alternative Methods

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