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Annual Report for Fiscal Year 2015

Annual Report for Fiscal Year 2015
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https://ntp.niehs.nih.gov/go/791011

NICEATM Support of Tox21

NICEATM conducted the following Tox21 projects. Full descriptions of those projects.

  • Use of high throughput assays and computational models to replace current Tier 1 Endocrine Disruptor Screening Program (EDSP) tests.
  • Validation of high throughput screening estrogen receptor transactivation assay.
  • Development of a reference database for estrogenic and androgenic activity.
  • In vitro to in vivo extrapolation using Tox21 data.
  • Evaluation of Tox21 data for predicting acute oral toxicity.
  • Development of domain-specific, quantitative structure-activity relationship (QSAR) models to predict estrogen receptor binding and activity.
  • Development of a computational model for androgen receptor pathway activity.
  • Development of QSAR models to predict androgen receptor binding and activity.
  • Development of a bioactivity-based read-across approach.
  • Analysis of the NTP-provided 52 compounds in the EPA ToxCast Phase II program.

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