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Annual Report for Fiscal Year 2015

Annual Report for Fiscal Year 2015
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https://ntp.niehs.nih.gov/go/792722

Organ System Toxicity

NTP studies toxicity of environmental substances on organ systems for development, reproduction, and the immune system. NTP immunotoxicity studies address adverse effects on the immune system that may result from exposure to environmental chemicals, biological materials, or therapeutic agents. Identifying substances with the potential to alter immune system function is critical to the public health field as these substances may lead to increased incidence of hypersensitivity disorders, autoimmune disease, infectious disease, or neoplasia. The table below lists organ systems toxicity studies during FY 2015.

Neurotoxicity, Developmental Toxicity, and Reproductive Toxicity Studies During FY 2015
Test Article CASRN* Species Testing Battery Length Route Study Scientist Status
Acrylamide 79-06-1 Rats Neurotoxicology assessment 3, 6, 12 and 24 months Gavage Beland Ongoing
Benzo(a)pyrene 50-32-8 Mice Immunotoxicity 28 days Gavage Rider Initiated
Dimethylethanolamine 108-01-0 Rats Conventional teratology GD** 6 to GD 20 Gavage McIntyre Completed
2-Hydroxy-4-methoxybenzophenone 131-57-7 Rats Developmental toxicity GD 6 to GD 15 Feed Hansen Ongoing
2-Hydroxy-4-methoxybenzophenone 131-57-7 Rats Developmental toxicity GD 6 to PND*** 21 Feed Hansen Ongoing
4-Methylcyclohexanemethanol 34885-03-5 Rats Conventional teratology GD 6 to GD 20 Gavage Auerbach Completed
4-Methylcyclohexanemethanol 34885-03-5 Mice Immunotoxicity 7 days Topical application Auerbach Initiated
4-Methylcyclohexanemethanol, crude N/A Mice Immunotoxicity 7 days Topical application Auerbach Initiated
4-Methylcyclohexanemethanol, crude N/A Mice Immunotoxicity 7 days Topical application Auerbach Initiated
Phenanthrene 85-01-8 Mice Immunotoxicity 28 days Gavage Rider Initiated
Sulfolane 126-33-0 Mice Immunotoxicity 13 weeks Gavage Blystone Initiated
Sulfolane 126-33-0 Rats Immunotoxicity 13 weeks Gavage Blystone Initiated
Vinpocetine 42971-09-5 Rats Teratology pilot studies GD 6 to GD 20 Gavage Catlin Completed
Vinpocetine 42971-09-5 Rats Conventional teratology GD 6 to GD 20 Gavage Catlin Initiated
Vinpocetine 42971-09-5 Rabbits Conventional teratology GD 7 to GD 28 Gavage Catlin Initiated

*CASRN = Chemical Abstracts Service Registry Number