NTP Logo

Annual Report for Fiscal Year 2015

Annual Report for Fiscal Year 2015
Menu
https://ntp.niehs.nih.gov/go/792732

Toxicology and Carcinogenicity Studies

NTP performs toxicity studies to provide dose-setting information for chronic studies and address specific deficiencies in the toxicology database for the chemical. Toxicology and carcinogenicity studies fall into two categories: prechronic toxicity studies and two-year toxicology and carcinogenicity studies. Studies are generally conducted in rats and mice. Each study type is performed according to the Specifications for the Conduct of Studies to Evaluate the Toxic and Carcinogenic Potential of Chemical, Biological, and Physical Agents in Laboratory Animals for the National Toxicology Program (January 2011). The tables below list toxicity studies, and chronic toxicity and carcinogenicity studies, that were initiated, ongoing, or completed during FY 2015.

Study Tables Below:
  • Prechronic Studies
  • Chronic Studies
Prechronic Toxicology and Carcinogenicity Studies FY 2015
Test Article CASRN* Species Length Route Study Scientist Status
AZT drug combinations, transplacental/neonatal study N/A Mice 28 days Gavage Beland Ongoing
N-Butylbenzenesulfonamide 3622-84-2 Mice 14 days Feed Rider Ongoing
1-Butyl-3-methylimidazolium chloride 79917-90-1 Mice, Rats 90 days Water Ryan Ongoing
1-Butyl-1-methylpyrrolidinium chloride 479500-35-1 Mice, Rats 90 days Water Ryan Ongoing
N-Butylpyridinium chloride 1124-64-7 Mice, Rats 90 days Water Ryan Ongoing
Cobalt 7440-48-4 Mice, Rats 2 weeks, 13 weeks Inhalation Behl Completed
4-Methylcyclohexanemethanol, crude N/A Rats 5 days Gavage Auerbach Ongoing
Cumene 98-82-8 Mice, Rats 14 days Inhalation Roberts Initiated
Dimethylamine borane 74-94-2 Mice, Rats 2 weeks Dermal Germolec Ongoing
N,N-Dimethyl-p-toluidine 99-97-8 Rats 5 days Gavage Dunnick Ongoing
1-Ethyl-3-methylimidazolium chloride 65039-09-0 Mice, Rats 90 days Water Ryan Ongoing
2-Ethyltoluene 611-14-3 Mice, Rats 14 days Inhalation Roberts Scheduled
3-Ethyltoluene 620-14-4 Mice, Rats 14 days Inhalation Roberts Scheduled
4-Ethyltoluene 622-96-8 Mice, Rats 14 days Inhalation Roberts Initiated
Garcinia cambogia extract 90045-23-1 Mice, Rats 14 days Feed Rider Ongoing
Glycidamide 5694-00-8 Mice, Rats 14 days, 90 days Water Beland Completed
Isopropylated phenol phosphate 68937-41-7 Mice 2 weeks Feed Behl Initiated
Carbon nanotube, 1020 long multiwalled  N/A Mice, Rats 30 days Inhalation Germolec Scheduled
Melamine and cyanuric acid combination N/A Rats 90 days Gavage Gamboa Ongoing
4-Methylcyclohexanemethanol 34885-03-5 Rats 5 days Gavage Auerbach Ongoing
Nanoscale silver 7440-22-4 Rats 13 weeks Gavage Boudreau Ongoing
Pentabromodiphenyl oxide (technical) (DE-71) 32534-81-9 Rats GD** 6 to PND*** 21 Gavage Dunnick Ongoing
3,3,4,4,5-Pentachlorobiphenyl (PCB 126) 57465-28-8 Rats GD 6 to PND 21 Gavage Dunnick Initiated
Perfluorodecanoic acid 335-76-2 Rats 28 days Gavage Blystone Completed
Perfluorohexane sulfonate potassium salt 3871-99-6 Rats 28 days Gavage Blystone Ongoing
Phenobarbital 50-06-6 Rats 13 weeks, GD 6 to PND 21 Gavage Dunnick Initiated
Propylene glycol phenyl ether 770-35-4 Rats 5 days Gavage Auerbach Ongoing
Sodium metavanadate 13718-26-8 Mice, Rats 14 days Water Roberts Completed
Sulfolane 126-33-0 Guinea Pigs, Mice, Rats 28 days Gavage Blystone Completed
2,2',4,4'-Tetrabromodiphenyl ether (BDE-47) 5436-43-1 Rats GD 6 to PND 21, GD 6 to GD 20, GD 6 to PND 21 Gavage Dunnick Ongoing
p-Toluidine 106-49-0 Rats 5 days Gavage Dunnick Ongoing
Triclosan 3380-34-5 Mice 90 days Dermal Fang Ongoing
Triphenyl phosphate 115-86-6 Mice 2 weeks Feed Behl Initiated
Tungsten 7440-33-7 Rats 28 days Intratracheal Behl Ongoing
Tungsten suboxide fibers N/A Rats 28 days Intratracheal Behl Ongoing
Usnea lichen N/A Mice, Rats 2 weeks Feed Leakey Ongoing
(+)-Usnic acid 7562-61-0 Mice, Rats 2 weeks, 90 days Feed Leakey Ongoing
Valerian (Valeriana officinalis L.) root extract 8057-49-6 Mice 14 days Gavage Roberts Initiated
Vanadyl sulfate 27774-13-6 Mice, Rats 14 days Water Roberts Completed
Vinylidene chloride 75-35-4 Mice, Rats 2 weeks, 13 weeks Inhalation Wyde Completed

*CASRN = Chemical Abstracts Service Registry Number
**GD: gestational day
***PND: postnatal day

 

Chronic Toxicity and Carcinogenicity Studies Ongoing During FY 2015

Test Article CASRN* Species Length Route Study Scientist Status

Aging cohort study, mouse strains:

  • 129S1/SvImJ
  • B6C3F1 (Jackson)
  • C3H/HeJ
  • C57BL/6J (Jackson)
  • CAST/EiJ (M. m. castaneus)
  • NZO/HiLtJ
  • PWK/PhJ
  • WSB/EiJ (M. m. domesticus)
  • A/J
  • NOD. B10Sn-H2(b)/J
N/A Mice 2 years N/A Dunnick Ongoing
alpha-Pinene 80-56-8 Mice, Rats 2 years Inhalation Rider Initiated
Antimony trioxide 1309-64-4 Mice, Rats 2 years Inhalation Stout Ongoing
AZT drug combinations, transplacental/neonatal study N/A Mice 2 years Gavage Beland Ongoing
AZT drug combinations, transplacental/carcinogenesis study N/A Mice 2 years In utero Beland Ongoing
Bisphenol A 80-05-7 Rats 2-years Gavage Delclos Ongoing
Black cohosh 84776-26-1 Mice, Rats 2 years Gavage Blystone Ongoing
2,3-Butanedione 431-03-8 Mice, Rats 2 years Inhalation Morgan Ongoing
Cell phone radiation: CDMA** N/A Mice, Rats 2 years Whole body exposure Wyde Ongoing
Cell phone radiation: GSM*** N/A Mice, Rats 2 years Whole body exposure Wyde Ongoing
p-Chloro-a,a,a-trifluorotoluene 98-56-6 Mice, Rats 2 years Inhalation Stout Ongoing
Dibutyl phthalate 84-74-2 Mice, Rats 2 years Feed Blystone Ongoing
Di(2-ethylhexyl) phthalate 117-81-7 Rats Perinatal and 2 years Feed Foster Ongoing
Furan 110-00-9 Rats 2 years Gavage Beland Ongoing
2-Hydroxy-4-methoxybenzophenone 131-57-7 Mice, Rats 2 years Feed McIntyre Ongoing
Insertional mutagenesis, definitive vector study N/A Mice 14 months Intravenous Germolec Ongoing
Trim VX N/A Mice, Rats 2 years Inhalation Ryan Ongoing
Pentabromodiphenyl oxide (technical) (DE-71) 32534-81-9 Mice, Rats 2 years Gavage Dunnick Ongoing
Perfluorooctanoic Acid 335-67-1 Rats 2 years Feed Blystone Ongoing
Resveratrol 501-36-0 Mice, Rats 2 years Gavage Germolec Ongoing
Sodium tungstate dihydrate 10213-10-2 Mice, Rats 2 years Water Behl Ongoing
Sulfolane 126-33-0 Mice, Rats 2 years Water Blystone Initiated
Triclosan 3380-34-5 Mice 2 years Dermal Fang Ongoing
Tris(chloropropyl)phosphate 13674-84-5 Mice, Rats 2 years Feed Ryan Ongoing
Zinc carbonate, basic 5263-02-5 Rats 2 years Feed Wyde Ongoing
*CASRN = Chemical Abstracts Service Registry Number
**CDMA: code division multiple access
***GSM: global system for mobile communication