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Annual Report for Fiscal Year 2016

Annual Report for Fiscal Year 2016
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https://ntptest.niehs.nih.gov/go/807171

RoC Activities

NTP submitted the 14th RoC to the U.S. Department of Health and Human Services (HHS) Secretary for review and approval in FY 2016 and HHS released the 14th RoC on November 3, 2016. This cumulative report contains 248 listings, of which seven were newly reviewed. The newly reviewed listings, include trichloroethylene, Epstein-Barr virus, human immunodeficiency virus type-1, human T cell lymphotropic virus type-1, Kaposi sarcoma-associated herpesvirus, and Merkel cell polyomavirus, all listed as known to be a human carcinogen; and the class cobalt and cobalt compounds that release cobalt in vivo, listed as reasonably anticipated to be a human carcinogen.

Other RoC activities in FY 2016 were primarily related to conducting the cancer hazard evaluations of several substances that were newly reviewed for the 14th RoC. The RoC Monograph on Cobalt and Cobalt Compounds that Release Cobalt In Vivo was finalized following the December 2015 NTP Board of Scientific Counselors’ meeting. On December 17, 2015, NTP convened a panel of experts to peer review five draft RoC monographs on Epstein-Barr Virus, human immunodeficiency virus type-1, human T cell lymphotropic virus type-1, Kaposi sarcoma-associated herpesvirus, and Merkel cell. The monographs for these five viruses were finalized following the June 2016 NTP Board of Scientific Counselors’ meeting.

Literature-based cancer hazard evaluations are being prepared for (1) shift work at night, light at night, and circadian disruption, (2) haloacetic acids found as disinfection by-products, and (3) Helicobacter pylori: Chronic infection. Concepts documents for haloacetic acids and H. pylori were presented to the NTP Board of Scientific Counselors at their April 11, 2016 meeting. Goldenseal Root Powder has also selected for review for the RoC. For a table listing RoC ongoing evaluations, go to RoC Substances Selected for Evaluation.

The Office of the Report on Carcinogens, in partnership with the Office of Health Assessment and Translation, convened a workshop titled Shiftwork at Night, Artificial Light at Night and Circadian Disruption and held on March 10-11, 2016. The purpose of the workshop was to obtain external scientific input on topics important for informing the literature-based health hazard assessments, including strategies for integrating data across evidence streams and exposure scenarios, data gaps, and research needs.

Additional Links for the RoC