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Annual Report for Fiscal Year 2016

Annual Report for Fiscal Year 2016
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https://ntp.niehs.nih.gov/go/807180

Newly Reviewed Listings for the 14th RoC

Candidate
CASRN*
Study Scientist
Primary Uses/Exposures Listing Status and Rationale
Trichloroethylene
79-01-6
Lunn
Industrial solvent best known for its use as a metal degreaser. Today it is mainly used for the synthesis of hydrofluorocarbon refrigerant. Known to be a human carcinogen

Linked to kidney cancer and possibly non-Hodgkin lymphoma
Epstein-Barr virus
N/A
Jahnke
Herpesvirus that causes infectious mononucleosis. Infects nine of 10 people worldwide and is transmitted via saliva. Known to be a human carcinogen

Linked to six types of cancer in humans: four types of lymphoma, nasopharyngeal and gastric cancer 
Human immunodefencity virus, type-1
N/A
Jahnke
Retrovirus that causes AIDS. Infects 1.2 million people. Transmitted via blood and body fluids.  Known to be a human carcinogen

Linked (or potentially linked) to 12 types of cancers 
Human T cell lymphotropic virus, type-1
N/A
Jahnke
Retrovirus that is usually asymptomatic. Transmitted via body fluids and blood. Known to be a human carcinogen

Linked to adult T-cell leukemia/lymphoma 
Kaposi sarcoma-associated virus
N/A
Jahnke
Herpesvirus usually causing asymptomatic infections. Transmitted via salvia and from mother to child Known to be a human carcinogen

Linked to Kaposi sarcoma and two types of lymphoma in humans 
Merkel cell polyomavirus
N/A
Jahnke
Polyomavirus whose route of transmission is not clear, but may be transmitted through skin shedding.
 
Known to be a human carcinogen

Linked to Merkel cell carcinoma
Cobalt and cobalt compounds that release cobalt in vivo
7440-48-4
Lunn
Naturally occurring metallic element that exists in different forms. Used to make alloys for industrial, medical, and military purposes; cemented carbides; as pigments; and for electronics and green energy. Reasonably anticipated to be a human carcinogen

Sufficient evidence of carcinogencity from studies in experimental animals and supporting mechanistic data

* Chemical Abstracts Service Registry Number

Additional Links for the RoC