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Annual Report for Fiscal Year 2016

Annual Report for Fiscal Year 2016
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https://ntp.niehs.nih.gov/go/807064

Completed NTP Reports

The results of NTP studies undergo peer review and are published in NTP report series. Long-term toxicology and carcinogenicity studies, generally two-years in length, are reported in the NTP Technical Report series. Toxicity reports are for shorter-term studies, generally up to 13 weeks. NTP Research Reports provide results of peer-reviewed NTP research and literature-analysis activitiesthat do not fall under the scope of existing NTP report series, such as research studies, rapid communications, and literature surveys. All peer reviewers are screened for conflict of interest prior to confirming their service. These reports are available on the NTP website and catalogued in PubMed. 

Technical Reports Published During FY 2016 Reporting Levels of Evidence of Carcinogenic Activity

NTP technical reports published in FY 2016 are listed in the table below. NTP used established criteria to evaluate the findings and determine the strength of the evidence for conclusions regarding the carcinogenic activity of each substance. The conclusions for level of evidence of carcinogenic activity are included in the table. NTP anticipates three draft technical reports will undergo peer review in FY 2017, as listed in the second table below.

Chemical Technical Report Number/CASRN* Use Male Rats Female Rats Male Mice Female Mice
Bromodichloroacetic Acid TR-583
71133-14-7
Forms when drinking water supplies containing natural organic matter are disinfected with chlorine-containing oxidizing compounds and when bromide is present in the source water. Clear evidence Clear evidence Clear evidence Clear evidence
Green Tea Extract TR-585
N/A
Nutraceutical supplements and medicinal uses containing green tea extract are commonly consumed for weight loss. Green tea extracts are popular ingredients in sunblocks, cream rinses, and other cosmetics. No evidence No evidence No evidence No evidence
Pentabromodiphenyl Ether Mixture [DE-71 (Technical Grade)] TR-589
32534-81-9
Flame retardant in furniture materials. Clear evidence Clear evidence Clear evidence Clear evidence

Technical Reports Expected to Undergo Peer Review in FY 2017

Chemical Technical Report Number/CASRN* Use
2,3 Butanedione TR-593
431-03-8
Artificial flavor formulations, such as cake mixes, flour, beer, wine, margarine, cheese, candy, crackers, cookies, ice cream, and many others food and beverage products.
p-Chloro-a,a,a-trifluorotoluene TR-594
98-56-6
Solvent used in paints and coatings, and as an industrial intermediate in the productions of other chemicals (e.g., herbicides, dyes, pharmaceuticals).
Zinc, dietary TR-592
5263-02-5
Used in wide range of industries including rubber production, animal feed supplement, fertilizer additive, cosmetics, drugs, paint pigment, dental cements, wood preservatives, batteries, galvanizing and metal work, textile production, television screens, watches, and smoke bombs.
 

Toxicity Reports Published During FY 2016

NTP Toxicity Reports evaluate and characterize the toxicologic potential of a substance under study conditions. NTP toxicity reports published in FY 2016 are listed in the table below.

Chemical Toxicity Report Number/
CASRN*
Use
Octahydro-tetramethyl-naphthalenyl-ethanone TOX-92
54464-57-2 (β-isomer)
68155-67-9 (α-isomer)
68155-66-8 (γ-isomer)
Perfume ingredient in soap, shampoo, cologne, liquid detergent compounds, and malodor-reducing compounds
p-Toluenesulfonamide TOX-88
70-55-3
Formed from chloramine-T, an antimicrobial agent used by the aquaculture industry to treat fish intended for human consumption. Chloramine-T is also widely used as a disinfectant in the medical, dental, veterinary, food processing, and agricultural industries.
alpha-Pinene TOX-81
80-56-8
Main component in turpentine and is used as a fragrance and flavoring ingredient.
Sodium thioglycolate TOX-80
367-51-1
Antioxidant, depilating agent, hair waving/straightening agent, and reducing agent ingredient in cosmetic industry.
 

Research Reports Published During FY 2016

The NTP research report series was launched in FY 2016 to promote transparency and reproducibility. The series also strengthens the science base and provide information useful for public health decision-makers. NTP research reports published in FY 2016 are listed in the table below.

Report Title Research Report Number
Systematic Literature Review on the Effects of Fluoride on Learning and Memory in Animal Studies RR-01
Organotin and Total Tin Levels in Danish Women of Reproductive Age RR-02

*CASRN = Chemical Abstracts Service Registry Number