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Annual Report for Fiscal Year 2016

Annual Report for Fiscal Year 2016


The Scientific Advisory Committee on Alternative Toxicological Methods (SACATM) is a federally chartered advisory committee established January 9, 2002, in response to the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) Authorization Act of 2000 (42 U.S.C. 285l-3(d)). SACATM advises ICCVAM, the NTP Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM), and the director of NIEHS and NTP regarding statutorily mandated duties of ICCVAM and activities of NICEATM. SACATM provides advice on priorities and activities related to the development, validation, scientific review, regulatory acceptance, implementation, and national and international harmonization of new, revised, and alternative toxicological test methods. The SACATM charter and current roster are available on the NTP website. The table below provides the roster for FY 2016. SACATM typically meets once a year and members serve rotating terms of up to four years. Lori White, Ph.D., served as the designated federal officer and manager of SACATM.

SACATM met once during FY 2016 on September 27, 2016, at NIEHS. At the meeting, ICCVAM and NICEATM updated SACATM on the activities since the last meeting. The focus of the meeting was a strategy for implementing the vision for regulatory toxicity testing in the 21st century. SACATM was updated on ICCVAM’s strategy for the six most commonly used acute animal tests and their roadmap for skin sensitization testing. Additional presentations included (1) moving away from animal models for toxicity testing, (2) impediments to adoption of alternative approaches, (3) coordinating activities between the federal government and stakeholders, (4) promoting adoption of alternative testing strategies, and (5) the next steps toward developing a strategy for implementing the vision for toxicity testing in the 21st century.

Members of SACATM, ICCVAM, and staff from NIEHS and NTP at the September 2016 SACATM meeting

SACATM Membership Roster FY 2016

Name and Title Affiliation Term End Date
Brian Berridge, D.V.M., Ph.D., D.A.C.V.P.
Director, WW Animal Research Strategy
King of Prussia, Pennsylvania
Lauren E. Black, Ph.D.
Senior Scientific Advisor
Navigators Services
Charles River Laboratories
Reno, Nevada
Tracie E. Bunton, D.V.M., Ph.D.
Eicarte LLC
Gettysburg, Pennsylvania
Joan M. Chapdelaine, Ph.D.
Senior Immunologist and Director, Business Development
Calvert Laboratories, Inc.
Scott Township, Pennsylvania
Mark G. Evans, D.V.M., Ph.D., A.C.V.P.
Research Fellow
La Jolla Laboratories
San Diego, California
Hisham Hamadeh, Ph.D., D.A.B.T., M.B.A.
Director, Comparative Biology and Safey Sciences
Amgen, Inc.
Thousand Oaks, California
William P. Janzen (Chair)
Executive Director of Lead Discovery
Epizyme, Inc.
Cambridge, Massachusetts
Safdar A. Khan, D.V.M., M.S., Ph.D., D.A.B.V.T.
Associate Director
Global Pharmacoavigilance
Kalamazoo, Michigan
Lawrence Milchak, Ph.D., D.A.B.T.
Senior Manager, Toxicology and Strategic Services
St. Paul, Minnesota
Pamela J. Spencer, Ph.D., D.A.B.T.
Director of Regulatory and Product Stewardship
ANGUS Chemical Company
Buffalo Grove, Illinois
Catherine E. Willett, Ph.D.
Regulatory Toxicology, Risk Assessment and Alternatives
The Humane Society of the United States
Gaithersburg, Maryland
Wei Xu, Ph.D.
Associate Professor
Department of Oncology
McArdle Laboratory for Cancer Research
University of Wisconsin at Madison
Madison, Wisconsin
Hao Zhu, Ph.D.
Assistant Professor
Department of Chemistry
Rutgers University at Camden
Camden, New Jersey