The Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) is a permanent interagency committee of NIEHS under NICEATM. Established by the ICCVAM Authorization Act of 2000 (42 U.S.C. 285i-3), its purpose is “to establish, wherever feasible, guidelines, recommendations, and regulations that promote the regulatory acceptance of new or revised scientifically valid toxicological tests that protect human and animal health and the environment, while reducing, refining, or replacing animal tests and ensuring human safety and product effectiveness.”
ICCVAM is composed of representatives from 15 U.S. federal regulatory and research agencies that generate or use toxicological and safety testing information. Warren Casey, Ph.D., serves as administrative director of ICCVAM.
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