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Annual Report for Fiscal Year 2016

Annual Report for Fiscal Year 2016

ICCVAM Activities

NICEATM provided support for six teleconferences and two in-person meetings held by ICCVAM in FY 2016. NICEATM also supported three ad hoc ICCVAM working groups focused on acute systemic toxicity, skin sensitization, and identification and characterization of reference chemicals for validation of in vitro endocrine disruptor assays.

The second ICCVAM Communities of Practice webinar was held on January 26, 2016. The webinar focused on applications of methods that use chemical structure, properties, and toxicity data to predict characteristics of untested chemicals. Alex Tropsha, Ph.D., of the University of North Carolina at Chapel Hill discussed how quantitative structure-activity relationship models allow chemical compounds to be characterized mathematically, enabling statistical predictions about the properties of untested chemicals. Louis Scarano, Ph.D., of the U.S. Environmental Protection Agency explained how quantitative tools and models are used to generate predictions about toxic effects of new chemicals. These predictions are then used to conduct occupational risk assessments and identify where further testing might be needed. Slide presentations from the webinar are available on the NTP website.  

ICCVAM with NICEATM support held its third public forum on May 25, 2016, at NIH in Bethesda, Maryland. Representatives from 12 ICCVAM member agencies were joined by attendees representing stakeholder groups and over 100 webcast viewers. ICCVAM members provided information about their agency’s activities relevant to the development and validation of test methods and approaches that may replace, reduce, or refine animal use. A proposal for a roadmap to replace animal use in U.S. safety testing was highlighted. Representatives from stakeholder groups praised recent progress made by ICCVAM and its member agencies towards replacing required animal tests with non-animal alternatives, and suggested future activities and areas that should receive increased focus. The agenda and presentations are available on the NTP website.

The 15 member agencies of ICCVAM are engaged in additional activities that support replacing, reducing, and refining animal use. Summaries of these activities can be found on the NTP website.

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