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Annual Report for Fiscal Year 2016

Annual Report for Fiscal Year 2016
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https://ntp.niehs.nih.gov/go/807079

Toxicology and Carcinogenicity Studies

NTP performs toxicity studies to provide dose-setting information for chronic studies and address specific deficiencies in the toxicology database for the chemical. Toxicology and carcinogenicity studies fall into two categories: prechronic toxicity studies and chronic two-year toxicology and carcinogenicity studies. Studies are generally conducted in rats and mice. Each study type is performed according to the Specifications for the Conduct of Studies to Evaluate the Toxic and Carcinogenic Potential of Chemical, Biological, and Physical Agents in Laboratory Animals for the National Toxicology Program (January 2011). The tables below list prechronic and chronic toxicity studies and carcinogenicity studies, that were initiated, ongoing, or completed during FY 2016.

Prechronic Toxicology and Carcinogenicity Studies FY 2016

Click the green + for information on the study scientist.

Test Article CASRN* Species Length Route Status Study Scientist
1020 Long multiwalled carbon nanotube N/A Mice, rats 30 days Inhalation Initiated Morgan
2-Ethylhexyl diphenyl phosphate 1241-94-7 Rats 5 days Gavage Ongoing Auerbach
2-Ethyltoluene 611-14-3 Mice, rats 14 days Inhalation Initiated Roberts
2,2'-Dimorpholinodiethyl ether 6425-39-4 Mice 28 days Gavage Initiated Roberts
2,2',4,4'-Tetrabromodiphenyl ether 5436-43-1 Rats GD 6 to PND 21 Gavage Ongoing Dunnick
3-Ethyltoluene 620-14-4 Mice, rats 14 days Inhalation Initiated Roberts
3,3,4,4,5-Pentachlorobiphenyl 57465-28-8 Rats GD 6  to PND 21 Gavage Ongoing Dunnick
4-Ethyltoluene 622-96-8 Mice, rats 14 days Inhalation Ongoing Roberts
4-Methylcyclohexanemethanol 34885-03-5 Rats 5 days Gavage Completed Auerbach
5-Amino-o-cresol 2835-95-2 Mice, rats 13 weeks Topical Application Completed Dunnick
Aloin 1415-73-2 Rats 13 weeks Dosed-Water Ongoing Boudreau
alpha-Pinene 80-56-8 Mice, rats 14 days Inhalation Completed Rider
alpha-Pinene 80-56-8 Mice, rats 13 weeks Inhalation Completed Rider
Aspergillus versicolor mold N/A Mice 13 weeks Inhalation Completed Germolec
Bis(2-Chloroethoxy)methane 111-91-1 Mice 10 days, 3 days Gavage Ongoing Dunnick
Black cohosh 84776-26-1 Mice 90 days Gavage Ongoing Cora
4-Methylcyclohexanemethanol, crude N/A Rats 5 days Gavage Completed Auerbach
Cumene 98-82-8 Mice, rats 14 days Inhalation Ongoing Roberts
Dimethylamine borane 74-94-2 Mice, rats 2 weeks Dermal Ongoing Germolec
Ephedrine + caffeine combination N/A Mice 10 days, 3 days Gavage Ongoing Dunnick
Formaldehyde 50-00-0 Mice 2 weeks Inhalation Ongoing Morgan
Formaldehyde 50-00-0 Mice 8 weeks Inhalation Ongoing Morgan
Fumonisin B1 116355-83-0 Mice, rats 13 weeks Dosed-Feed Ongoing Walters
Garcinia cambogia extract 90045-23-1 Mice, rats 14 days Dosed-Feed Completed Rider
Ginkgo biloba extract 90045-36-6 Rats 5 days Gavage Initiated Rider
Goldenseal extract 84603-60-1 Rats 5 days Gavage Initiated Rider
Green tea extract N/A Rats 5 days Gavage Initiated Rider
Green tea extract N/A Mice, rats 13 weeks Gavage Completed Blystone
Hydroxyurea 127-07-1 Mice, rats 14 days, 13 weeks Intraperitoneal Injection Ongoing Ryan
Ionic Liquid: 1-butyl-1-methylpyrrolidinium chloride 479500-35-1 Mice, rats 90 days Dosed-Water Ongoing Ryan
Ionic Liquid: 1-butyl-3-methylimidazolium chloride 79917-90-1 Mice, rats 90 days Dosed-Water Ongoing Ryan
Ionic Liquid: 1-ethyl-3-methylimidazolium chloride 65039-09-0 Mice, rats 90 days Dosed-Water Ongoing Ryan
Ionic Liquid: N-butylpyridinium chloride 1124-64-7 Mice, rats 90 days Dosed-Water Ongoing Ryan
Isodecyl diphenyl phosphate 29761-21-5 Rats 5 days Gavage Ongoing Auerbach
Isopropylated phenol phosphate 68937-41-7 Mice 2 weeks Dosed-Feed Ongoing Behl
Isopropylated phenol phosphate 68937-41-7 Rats 5 days Gavage Ongoing Auerbach
Melamine + cyanuric acid combination N/A Rats 90 days Gavage Ongoing Gamboa
Melamine + cyanuric acid combination N/A Rats 90 days Gavage Ongoing Gamboa
Melamine + cyanuric acid combination N/A Rats 90 days + recovery Gavage Initiated Gamboa
TRIM VX N/A Mice, rats 13 weeks Inhalation Ongoing Ryan
Microbiome N/A N/A 14 days N/A Ongoing Cerniglia
N-Butylbenzenesulfonamide 3622-84-2 Mice 14 days Dosed-Feed Ongoing Rider
N,N-Dimethyl-p-toluidine 99-97-8 Rats 5 days Gavage Ongoing Dunnick
Nanoscale silver 7440-22-4 Rats 13 weeks Gavage Ongoing Boudreau
p-Toluidine 106-49-0 Rats 5 days Gavage Ongoing Dunnick
Pentabromodiphenyl ether mixture [DE-71 (Technical Grade)] 32534-81-9 Mice, rats 13 weeks Gavage Completed Dunnick
Pentabromodiphenyl ether mixture [DE-71 (Technical Grade)] 32534-81-9 Rats GD 6  to PND 21 Gavage Ongoing Dunnick
Pentachlorophenol, purified 87-86-5 Mice 4 weeks Dosed-Feed Ongoing Goldstein
Perfluorohexane sulfonate potassium salt 3871-99-6 Rats 28 days Gavage Ongoing Blystone
Perfluorohexanoic acid 307-24-4 Rats 28 days Gavage Ongoing Blystone
Perfluorooctanoic acid 335-67-1 Rats 28 days Gavage Ongoing Blystone
Phenolic benzotriazoles  (2-(2H-benzotriazol-2-yl)-4,6-bis(1-methyl-1-phenylethyl)phenol) 70321-86-7 Rats 14 days Gavage Initiated Blystone
Phenolic benzotriazoles (2-(2H-benzotriazol-2-yl)-4-tert-butylphenol) 3147-76-0 Rats 14 days Gavage Initiated Blystone
Phenolic benzotriazoles (2-(2H-benzotriazol-2-yl)-4,6-bis(1,1-dimethylpropyl)phenol) 25973-55-1 Rats 14 days Gavage Initiated Blystone
Phenolic benzotriazoles (2-(2H-benzotriazol-2-yl)phenol) 10096-91-0 Rats 14 days Gavage Initiated Blystone
Phenolic benzotriazoles (2-(5-chloro-2H-benzotriazol-2-yl)-4,6-bis(1,1-dimethylethyl)phenol) 3864-99-1 Rats 14 days Gavage Initiated Blystone
Phenolic benzotriazoles (3-(2H-benzotriazol-2-yl)-5-(1,1-dimethylethyl)-4-hydroxybenzenepropanoic acid, octyl ester) 84268-23-5 Rats 14 days Gavage Initiated Blystone
Phenolic benzotriazoles (bumetrizole) 3896-11-5 Rats 14 days Gavage Initiated Blystone
Phenolic benzotriazoles (drometrizole) 2440-22-4 Rats 14 days Gavage Initiated Blystone
Phenolic benzotriazoles (octrizole) 3147-75-9 Rats 14 days Gavage Initiated Blystone
Propylene glycol phenyl ether 770-35-4 Rats 5 days Gavage Completed Auerbach
Sodium metavanadate 13718-26-8 Mice, rats 90 days Dosed-Water Initiated Roberts
Sodium thioglycolate 367-51-1 Mice, rats 2 weeks Topical Application Completed Mercado-Feliciano
Sodium thioglycolate 367-51-1 Mice, rats 13 weeks Topical Application Completed Mercado-Feliciano
tert-Butylphenyl diphenyl phosphate 56803-37-3 Rats 5 days Gavage Ongoing Auerbach
Tetrabromobisphenol A 79-94-7 Rats 13 weeks Gavage Ongoing Dunnick
Triclosan 3380-34-5 Mice 90 days Dermal Ongoing Fang
Tricresyl phosphate 1330-78-5 Rats 5 days Gavage Ongoing Auerbach
Trimethylsilyldiazomethane 18107-18-1 Mice, rats 10 days Inhalation Initiated Gwinn
Triphenyl phosphate 115-86-6 Mice 2 weeks Dosed-Feed Ongoing Behl
Usnea lichen N/A Mice, rats 2 weeks Dosed-Feed Ongoing Leakey
(+)-Usnic acid 7562-61-0 Mice, rats 2 weeks Dosed-Feed Ongoing Leakey
(+)-Usnic acid 7562-61-0 Mice, rats 90 days Dosed-Feed Ongoing Leakey
Valerian (Valeriana officinalis L.) root extract 8057-49-6 Mice 90 days Gavage Ongoing Roberts
Vanadyl sulfate 27774-13-6 Mice, rats 90 days Dosed-Water Initiated Roberts

Chronic Toxicity and Carcinogenicity Studies Ongoing During FY 2016

Test Article CASRN* Species Length Routes Status Study Scientist

Aging cohort study, mouse strains:

  • 129S1/SvImJ
  • B6C3F1 (Jackson)
  • C3H/HeJ
  • C57BL/6J (Jackson)
  • CAST/EiJ (M. m. castaneus)
  • NZO/HiLtJ
  • PWK/PhJ
  • WSB/EiJ (M. m. domesticus)
  • A/J
  • NOD. B10Sn-H2(b)/J
N/A Mice 2 years N/A Ongoing Dunnick
alpha-Pinene 80-56-8 Mice, rats 2 years Inhalation Ongoing Rider
Antimony trioxide 1309-64-4 Mice, rats 2 years Inhalation Ongoing Stout
AZT drug combinations, transplacental/carcinogenesis study N/A Mice 2 years In utero Ongoing Beland
AZT drug combinations, transplacental/neonatal study N/A Mice 2 years Gavage Ongoing Beland
Bisphenol A 80-05-7 Rats 2-years Gavage Ongoing Delclos
Black cohosh 84776-26-1 Mice, rats 2 years Gavage Ongoing Blystone
1,3-Butadiene 106-99-0 Mice 2 years Inhalation Ongoing Bucher
2,3-Butanedione 5263-02-5 Rats 2 years Dosed-feed Ongoing Catlin
2,3-Butanedione 335-67-1 Rats 2 years Dosed-feed Ongoing Blystone
2,3-Butanedione 431-03-8 Mice, rats 2 years Inhalation Ongoing Morgan
Cell phone radiation: code division multiple access N/A Mice, rats 2 years Whole body exposure Ongoing Wyde
Cell phone radiation: global system for mobile communication N/A Mice, rats 2 years Whole body exposure Ongoing Wyde
Di(2-ethylhexyl) phthalate 117-81-7 Rats Perinatal + 2 years Dosed-feed Ongoing Foster
Di(2-ethylhexyl) phthalate 117-81-7 Rats 2 years Dosed-feed Ongoing Foster
Dibutyl phthalate 84-74-2 Mice, rats 2 years Dosed-feed Ongoing Blystone
Furan 110-00-9 Rats 2 years Gavage Ongoing Beland
2-Hydroxy-4-methoxybenzophenone 131-57-7 Mice, rats 2 years Dosed-feed Ongoing McIntyre
Insertional mutagenesis, definitive vector study N/A Mice 14 months Intravenous Ongoing Germolec
1020 Long multiwalled carbon nanotube N/A Mice, rats 2 years Inhalation Initiated Morgan
TRIM VX N/A Mice, rats 2 years Inhalation Ongoing Ryan
Nitrofurazone 59-87-0 Mice 2 years Dosed-feed Ongoing Davis
p-Chloro-a,a,a-trifluorotoluene 98-56-6 Mice, rats 2 years Inhalation Ongoing Stout
Perfluorooctanoic acid 335-67-1 Rats 2 years Dosed-feed Ongoing Blystone
Resveratrol 501-36-0 Mice, rats 2 years Gavage Ongoing Germolec
Sodium fluoride 7681-49-4 Rats 2 years Dosed-water Ongoing Irwin
Sodium tungstate dihydrate 10213-10-2 Mice, rats 2 years Dosed-water Ongoing Behl
Sulfolane 126-33-0 Mice, rats 2 years Dosed-water Ongoing Blystone
Triclosan 3380-34-5 Mice 2 years Dermal Ongoing Fang
Tris(chloropropyl)phosphate 13674-84-5 Mice, rats 2 years Dosed-feed Ongoing Ryan
*CASRN = Chemical Abstracts Service Registry Number
**GD: gestational day
***PND: postnatal day