NTP Logo

Annual Report for Fiscal Year 2016

Annual Report for Fiscal Year 2016
Menu
https://ntp.niehs.nih.gov/go/807088

Modified One-Generation Reproduction Studies

NTP modified one-generation study design emphasizes a full evaluation of the first generation offspring animals, and uses fewer animals than the classical multigenerational study design. These studies generate information on the effects of substances on prenatal development, postnatal development, and reproduction. The table below lists planned or ongoing modified one-generation studies.

Modified One-Generation Studies in FY 2016

Test Article CASRN* Species Planned Cohorts Route Status Study Scientist
2,2'-Dimorpholinodiethyl ether 6425-39-4 Rats Repeated dose Gavage Initiated Roberts
Ethylene glycol 2-ethylhexyl ether 1559-35-9 Rats Dose range finding Gavage Initiated Blystone
Isopropylated phenol phosphate 68937-41-7 Rats Dose range finding Dosed-feed Ongoing Behl
Resveratrol 501-36-0 Rats F0 generation Gavage Ongoing Germolec
Simvastatin 79902-63-9 Rats Dose range finding Gavage Ongoing McIntyre
Triphenyl phosphate 115-86-6 Rats Dose range finding Dosed-feed Ongoing Behl
Valerian (Valeriana officinalis L.) root extract 8057-49-6 Rats Dose range finding Gavage Ongoing Roberts
*CASRN = Chemical Abstracts Service Registry Number
[1] Dose range-finding: to find the ideal dose for toxicological studies.