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Annual Report for Fiscal Year 2016

Annual Report for Fiscal Year 2016
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https://ntp.niehs.nih.gov/go/807130

Organ System Toxicity

NTP studies toxicity of environmental substances on organ systems for development, reproduction, and the immune system. NTP immunotoxicity studies address adverse effects on the immune system that may result from exposure to environmental chemicals, biological materials, or therapeutic agents. Identifying substances with the potential to alter immune system function is critical to the public health field as these substances may lead to increased incidence of hypersensitivity disorders, autoimmune disease, infectious disease, or neoplasia. The table below lists organ systems toxicity studies during FY 2016.

Neurotoxicity, Developmental Toxicity, and Reproductive Toxicity Studies During FY 2016

Click the green + for information on the study scientist.

Test Article CASRN* Species Testing Battery Length Route Status Study Scientist
Acrylamide 79-06-1 Rats Neurotoxicology assessment  Phase 1: 3 and 6 months; phase 2: 12 and 24 months Gavage Ongoing Beland
Autumn sunset true color concentrate N/A Mice Immunotoxicity 6 days Subcutaneous injection Ongoing Howard
Benzo(a)pyrene 50-32-8 Mice Immunotoxicity 28 days Gavage Ongoing Rider
Bisphenol AF 1478-61-1 Rats Immunotoxicity GD 6 - PND 96 Dosed-feed Initiated Sutherland
Dibenz(a,h)anthracene 53-70-3 Mice Immunotoxicity 8 GD - PND 42 Subcutaneous injection Ongoing Germolec
Diethylene glycol dimethyl ether 111-96-6 Mice Conventional teratology  11 GD (PLUG=GD0) Gavage Ongoing Hardin
Dimethylethanolamine 108-01-0 Rats Conventional teratology  GD 6 to GD 20 Gavage Completed McIntyre
Double dark fudge true color concentrate N/A Mice Immunotoxicity 7 days Subcutaneous injection Ongoing Howard
Double fudge concentrate N/A Mice Immunotoxicity 8 days Subcutaneous injection Ongoing Howard
Efavirenz 154598-52-4 Mice Teratology pilot studies  GD 5 - PND 21 Gavage Ongoing McIntyre
Ethylene oxide 75-21-8 Rabbit Conventional teratology  7 to 19 GD or 1 to 19 GD Inhalation Ongoing Hardin
2-Hydroxy-4-methoxybenzophenone 131-57-7 Rats Developmental toxicity  GD 6 to GD 15 Dosed-feed Ongoing Hansen
2-Hydroxy-4-methoxybenzophenone 131-57-7 Rats Developmental toxicity  GD 6 to GD 15 Dosed-feed Ongoing Hansen
2-Hydroxy-4-methoxybenzophenone 131-57-7 Rats Developmental toxicity  GD 6  to PND 21 Dosed-feed Ongoing Hansen
4-Methylcyclohexanemethanol 34885-03-5 Mice Immunotoxicity 7 days Topical application Completed Auerbach
4-Methylcyclohexanemethanol, crude N/A Mice Immunotoxicity 7 days Topical application Completed Auerbach
4-Methylcyclohexanemethanol, crude N/A Mice Immunotoxicity 7 days Topical application Completed Auerbach
Nonylphenol 84852-15-3 Rats Multigenerational screen 20 weeks Dosed-feed Ongoing Newbold, Delclos
Phenanthrene 85-01-8 Mice Immunotoxicity 28 days Gavage Ongoing Rider
Pyrene 129-00-0 Mice Immunotoxicity 28 days Gavage Initiated Germolec
Rosewood true color concentrate N/A Mice Immunotoxicity 6 days Subcutaneous injection Ongoing Howard
Sodium metavanadate 13718-26-8 Mice Immunotoxicity 28 days Dosed-water Initiated Roberts
Sulfolane 126-33-0 Mice Immunotoxicity 13 weeks Gavage Ongoing Blystone
Sulfolane 126-33-0 Rats Immunotoxicity 13 weeks Gavage Ongoing Blystone
Tenofovir disoproxil Ffmarate 202138-50-9 Mice Teratology pilot studies  GD 5 - PND 21 Gavage Initiated McIntyre
Tricombination  FTC:TDF:EFV (1:1.5:3) N/A Mice Maternal transfer  GD 5-15 Gavage Initiated McIntyre
Tricombination  FTC:TDF:EFV (1:1.5:3) N/A Mice Teratology pilot studies GD 5 - GD 18 Gavage Initiated McIntyre
Vinpocetine 42971-09-5 Rats Conventional teratology  GD 6 to GD 20 Gavage Completed Catlin
Vinpocetine 42971-09-5 Rabbit Conventional teratology GD 7 to GD 28 Gavage Completed Catlin
Vinyl toluene 25013-15-4 Rats Dominant lethal  5 consecutive days Intraperitoneal injection Ongoing Boorman
*CASRN = Chemical Abstracts Service Registry Number
**GD = gestational day
***PND = postnatal day