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Annual Report for Fiscal Year 2017

Annual Report for Fiscal Year 2017

Interagency Agreements

In FY 2017, NIEHS provided support for NTP activities through interagency agreements with other federal agencies.


Under an interagency agreement, NIEHS and FDA conduct toxicology studies on FDA-regulated agents nominated to NTP at the National Center for Toxicological Research. These studies are designed to provide FDA and other regulatory agencies with hazard identification and dose-response data to support risk assessment and risk management decisions that could affect public health. The interagency agreement supports studies on endocrine active agents, dietary supplements, food contaminants, AIDS therapeutics, pediatric medicines, electromagnetic radiation, cosmetics, and nanoscale materials. Studies in these areas have produced 18 published NTP Technical Reports and over 250 peer-reviewed journal publications. The studies have led to an increased understanding of the pharmacokinetics, mode of action, and dose-response relationships of the substances and to refinements of risk assessment models. Further information about NTP at the National Center for Toxicological Research and current research can be found in the Partner Agency Research section of this annual report.


NIEHS/NTP has two interagency agreements with the National Institute for Occupational Safety and Health (NIOSH). Studies under the interagency agreement on "Immunotoxicity of Workplace Xenobiotics" assess the potential toxicity of exposures to substances such as fungi, mycotoxins, volatile organic compounds, lead, latex, nickel, isocyanates, nanomaterials, and beryllium in occupationally exposed populations such as miners, farmers, health care workers, autoworkers, and firefighters. A second interagency agreement between NIEHS and NIOSH supports development of methods to assess complex mixtures, such as asphalt fumes, welding fumes, and tungsten fibers, and to conduct occupational exposure assessments to identify toxicologically relevant exposures. Research under these agreements in FY 2017 evaluated occupational exposure to bisphenol A, alternative flame retardants, and polycyclic aromatic hydrocarbons in coal tar sealants. For more information, see the Partner Agency Research section of the Annual Report.


This interagency agreement supports ongoing and anticipated studies conducted at the National Center for Advancing Translational Sciences/Division of Pre-Clinical Innovation to evaluate high-throughput and high-content screening assays in support of Tox21. Tox21 is a collaboration among federal agencies to characterize the potential toxicity of chemicals by using cells and isolated molecular targets instead of laboratory animals. This interagency agreement between NIEHS/NTP and the division produces data for information-poor substances to help prioritize them for further studies, including toxicological evaluation, mechanisms of action investigation, and development of predictive modeling for biological response.

Additional Agreements

NTP also established several smaller interagency agreements to conduct research, listed below.

Additional Interagency Agreements in FY 2017

Study—Agency Description
Development of Tools for Evaluating NTP’s Effectiveness—U.S. Department of Energy Research and develop tools, such as publication mining tools, that NTP can use to evaluate the use and impact of its work across the agencies and stakeholders to whom the work is disseminated and extract and organize data (e.g., potential outcomes and impacts) from NTP’s large inventory of documents (e.g., publications and progress reports).
Accelerating Development and Use of Computational Methods and Models—Environmental Protection Agency Accelerate development and use of methods/models for quantitative and qualitative risk assessments of environmental chemicals.