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Annual Report for Fiscal Year 2017

Annual Report for Fiscal Year 2017
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https://ntp.niehs.nih.gov/go/837925

Completed NTP Reports

The findings of NTP studies and research projects are published in three types of NTP reports.

  • NTP Technical Reports document long-term toxicology and carcinogenicity studies, generally of 2 years’ duration.
  • Toxicity Reports document shorter-term studies, generally up to 13 weeks’ duration.
  • NTP Research Reports provide the results of research studies, rapid communications, and literature surveys that do not fall under the scope of the first two report series.
All published NTP reports are peer reviewed by experts who are screened for conflicts of interest prior to their service. NTP reports completed in FY 2017, and in prior years, are available on the NTP website and catalogued in PubMed.

Technical Reports Published During FY 2017 Reporting Levels of Evidence of Carcinogenic Activity

NTP Technical Reports published in FY 2017 are listed below. NTP used established criteria to evaluate the findings and determine the strength of evidence for conclusions regarding the carcinogenic activity of each substance. The conclusions for level-of-evidence of carcinogenic activity are included.

Chemical Technical Report Number (CASRN*) Use Evidence of Carcinogenic Activity
Male Rats Female Rats Male Mice Female Mice
Indole-3-Carbinol TR-584
(700-06-1)
Natural component of brassica vegetables; marketed as a dietary supplement and cancer preventive agent No evidence Some evidence Clear evidence No evidence
TRIM® VX TR-591
(NA)
Metalworking fluid used as a lubricant and coolant liquid and for cleaning tools and parts during cutting, drilling, milling, and grinding Equivocal evidence Equivocal evidence Clear evidence Clear evidence

*CASRN = Chemical Abstracts Service Registry Number

Technical Reports that Underwent Peer Review in FY 2017

Three draft technical reports, listed below, underwent peer review in FY 2017. The NTP website provides further information about these and other past technical reports peer review meetings.

Chemical Technical Report Number (CASRN*) Use

Report Conclusions as Written and Panel Vote

2,3-Butanedione TR-593
(431-03-8)

Used in artificial flavor formulations, such as microwave popcorn, cake mixes, flour, beer, wine, margarine, cheese, candy, crackers, cookies, ice cream, and many others food and beverage products.

"Exposure to 2,3-butanedione resulted in increased incidences of nonneoplastic lesions of the nose, larynx, trachea, lung, and eye in male and female rats and mice."


4 yes, 2 no, 0 abstentions

Panelists who voted "no" recommended clear evidence of carcinogenic activity for male rats and some evidence of carcinogenic activity for female mice.

p-Chloro-α,α,α-trifluorotoluene TR-594
(98-56-6)
Solvent used in paints and coatings and as an industrial intermediate in the production of other chemicals (e.g., herbicides, dyes, pharmaceuticals). "Exposure to p-chloro-α,α,α-trifluorotoluene caused increased incidences of nonneoplastic lesions in the lung and liver of male and female rats and mice, in the nose of male rats, in the adrenal medulla and uterus of female rats, in the forestomach of male and female mice, and in the larynx in male mice. Exposure to p-chloro-α,α,α-trifluorotoluene caused increased severity of nonneoplastic lesions in the kidney of male rats."


6 yes, 0 no, 0 abstentions

Zinc, dietary TR-592
(5263-02-5)
Used in a wide range of industries including rubber production, animal feed supplement, fertilizer additive, cosmetics, drugs, paint pigment, dental cements, wood preservatives, batteries, galvanizing and metal work, textile production, television screens, watches, and smoke bombs. "Exposure to diets containing excess zinc resulted in increased incidences of nonneoplastic lesions of the pancreas in male and female rats. Exposure to diets deficient in zinc resulted in increased incidences of nonneoplastic lesions of the testes in male rats."


6 yes, 0 no, 0 abstentions

*CASRN = Chemical Abstracts Service Registry Number

Toxicity Reports Published During FY 2017

NTP Toxicity Reports evaluate and characterize the toxicological potential of a substance under study conditions. NTP Toxicity Reports published in FY 2017 are listed below.

Chemical Toxicity Report Number (CASRN*) Use
o-Chloropyridine TOX-83
(109-09-1)
Intermediate in synthetic organic, pharmaceutical, and agricultural chemical (fungicides, herbicides) manufacture. Also used as a catalyst for phase transfer and is a key intermediate in the manufacture of pyrithione-based biocides for use in cosmetics and various pharmaceutical products.
Tetrabromobisphenol A-bis(2,3-dibromopropyl ether) TOX-85
(21850-44-2)
Flame retardant in electronics, building and construction materials, and automotive materials.
 
*CASRN = Chemical Abstracts Service Registry Number

Research Reports Published During FY 2017

The NTP Research Report series was launched in FY 2016 to promote transparency and reproducibility. The series strengthens the science base and provides information useful for public health decision-makers. NTP Research Reports published in FY 2017 are listed below.

Report Title Research Report Number
Absence of Formaldehyde-Induced Neoplasia in Trp53 Haploinsufficient Mice Exposed by Inhalation RR-03