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Annual Report for Fiscal Year 2017

Annual Report for Fiscal Year 2017

Letter From the NIEHS and NTP Director

In fiscal year (FY) 2017, NTP continued to advance toxicology and inform public health policy by providing information to decision makers and the public about substances in our environment. Numerous studies were published on substances of public health concern, such as flame retardants, metals, and widely used industrial chemicals. Among these is the first study to investigate occupational exposure to bisphenol A by manufacturing workers in the United States.

NTP engaged in several activities to advance alternatives to animal testing. The NTP Interagency Center for the Evaluation of Alternative Toxicological Methods sponsored several venues to receive stakeholder input on a draft Strategic Roadmap toward new approaches to safety evaluation of chemicals and medical products. In addition, the "Tox21" initiative worked to develop high-throughput 3D tissue culture models that mimic the functionality of specific organ tissues to predict responses to environmental exposures.

The NTP Office of the Report on Carcinogens held a workshop to obtain external scientific input on topics important for informing their literature-based cancer hazard assessments for shift work at night, light at night, and circadian disruption.

The NTP Office of Health Assessment and Translation published the NTP Monograph on Immunotoxicity Associated with Exposure to Perfluorooctanoic Acid or Perfluorooctane Sulfonate. This evaluation was the first to reach hazard conclusions using the new systematic-review approach for study assessment and evidence integration.

I invite you to read this report to learn about what we accomplished in FY 2017 to safeguard public health by informing policy with the best science.

Linda S. Birnbaum, Ph.D., D.A.B.T., A.T.S.

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Dr. Linda Birnbaum

Dr. Birnbaum has served as the Director of the National Institute of Environmental Health Sciences (NIEHS) and the National Toxicology Program (NTP) since 2009. (Photo courtesy of Steve McCaw)