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Annual Report for Fiscal Year 2017

Annual Report for Fiscal Year 2017

ICCVAM Meetings

NICEATM supported six teleconferences and three in-person meetings held by ICCVAM in FY 2017. These included one in-person meeting and three teleconferences of ICCVAM representatives developing "A Strategic Roadmap for Establishing New Approaches to Evaluate the Safety of Chemicals and Medical Products in the United States."

NICEATM also supported seven ad hoc ICCVAM workgroups focused on acute systemic toxicity, ocular and dermal irritation, developmental and reproductive toxicity, skin sensitization, use of read-across in toxicity testing applications, in vitro-to-in vivo extrapolation, and identification and characterization of reference chemicals for validation of in vitro endocrine disruptor assays.

The third ICCVAM Communities of Practice webinar was held on January 24, 2017. The webinar emphasized the importance of understanding the structural and functional diversity of chemical sets used in developing and validating alternative approaches to traditional in vivo toxicology test methods. Denis Fourches, Ph.D., of North Carolina State University described chemoinformatics methods for predicting toxicity. Kamel Mansouri, Ph.D., of the Environmental Protection Agency (EPA) presented case studies on how such methods have been successfully applied. Slide presentations from the webinar are available on the NTP website.

ICCVAM, with NICEATM support, held its fourth public forum on May 23, 2017, at the National Institutes of Health (NIH) in Bethesda, Maryland. Representatives from 10 ICCVAM member agencies were joined by attendees representing stakeholder groups and over 100 webcast viewers. ICCVAM members provided information about their agency activities on the development and validation of test methods and approaches that could replace, reduce, or refine animal use. Stakeholder groups suggested areas to be addressed and encouraged development of the strategic roadmap. The agenda and presentations are available on the NTP website.

Related Annual Report Pages:
ICCVAM Test Method Evaluation Activities
ICCVAM International Validation Activities
Strategic Roadmap for New Approaches to Evaluate the Safety of Chemicals and Medical Products