The Tox21 research initiative aims to improve regulatory hazard assessment of substances potentially harmful to humans and the environment. Tox21 uses in vitro high-throughput screening assays to evaluate the biological activity of compounds in a 10,000 compound library and to map the observed activities to toxicity pathways.
One goal of Tox21 is to incorporate in vitro assay data into models that can be used to predict toxic (or adverse) effects in humans resulting from chemical exposures. NICEATM provides support to the Tox21 effort primarily through its computational toxicology group. Specific NICEATM projects in support of Tox21 are included in the Tox21 Projects section.