Webinar Series: Using Informatics to Improve Data Analysis of Chemical Screening Assays Conducted in Zebrafish
NICEATM presented a webinar series in February and March 2017 as part of the NTP Systematic Evaluation of the Application of Zebrafish in toxicology initiative. Zebrafish is a useful vertebrate model for toxicological screening studies because of its small size and rapid development, but a lack of harmonization in several key protocol components hinders the model’s broader adoption. This webinar series examined how variability in protocols for toxicological screening studies using zebrafish might be addressed by implementing standardized nomenclature systems or ontologies.
The webinar series was open to the public and viewed by over 100 participants. The webinars also provided information on an April 2017 meeting at NIEHS where expert investigators and data scientists discussed how to improve zebrafish screening data analysis by implementing ontologies. A report from the meeting describing recommendations on best practices and identifying technology development and other needs is planned for publication in FY 2018.
Presentations from the webinar series are available on the NTP website.
NICEATM and the Human Toxicology Project Consortium organized a June 2017 workshop, BioMed21 – A Human Pathway-based Approach to Disease and Medicine.
Recognition is growing for the need for greater focus on human-relevant data to increase the success rate of drug development. Such data will support implementation of methods to assess chemical toxicity that are based on human biological pathways. Several international projects are underway to mine literature, collect data, and organize data into adverse outcome pathways. This workshop assembled representatives from several of these projects to identify barriers and opportunities for improvement and to recommend support for implementation of a human systems biology platform to understand disease and improve interventions.
More information about the workshop is available on the NTP website.