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Annual Report for Fiscal Year 2017

Annual Report for Fiscal Year 2017
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https://ntp.niehs.nih.gov/go/838034

Disposition, Metabolism, and Toxicokinetic Studies

Complete dosimetry of a chemical or physical agent describes its absorption, distribution, metabolism, and excretion in the body of both humans and test animals at differing levels of exposure, of all ages, via several routes of exposure, and under varying genetic backgrounds. Substances evaluated during FY 2017 are listed below.

Disposition, Metabolism, and Toxicokinetics Studies During FY 2017 

Test Article CASRN* Species Route Status Study Scientist
2-((1-(4-Phenoxyphenoxy)propan-2-yl)oxy)pyridine 95737-68-1 Rabbit Gavage Initiated Vicki Sutherland
2-((1-(4-Phenoxyphenoxy)propan-2-yl)oxy)pyridine 95737-68-1 Rats Gavage Initiated Vicki Sutherland
2-Ethylhexyl p-Methoxycinnamate 5466-77-3 Mice, Rats Dermal, Gavage, Intravenous Completed Barry McIntyre
2-Ethylhexyl p-Methoxycinnamate 5466-77-3 Rats Dosed-Feed, Gavage, Intravenous Ongoing Barry McIntyre
Bisphenol AF 1478-61-1 Mice, Rats Gavage, Intravenous Ongoing Vicki Sutherland
Bisphenol S 80-09-1 Mice, Rats Gavage, Intravenous Completed Vicki Sutherland
Efavirenz (EFV) 154598-52-4 Mice Gavage Ongoing Barry McIntyre
Emtricitabine (FTC) 143491-57-0 Mice Gavage Ongoing Barry McIntyre
Hydroquinone 123-31-9 Mice, Rats Gavage, Intravenous, Topical Application Completed Vicki Sutherland
Nanoscale Silver 7440-22-4 Rats Gavage Ongoing Nigel Walker
Nanoscale Silver 7440-22-4 Rats Intravenous Ongoing Nigel Walker
N-Butylbenzenesulfonamide 3622-84-2 Mice, Rats Gavage, Intravenous Completed Cynthia Rider
Resveratrol 501-36-0 Mice, Rats Gavage, Intravenous Ongoing Dori Germolec
Sodium arsenite 7784-46-5 Mice, Monkey, Rats Dosed-Feed, Dosed-Water, Gavage Ongoing Daniel Doerge
Sulfolane 126-33-0 Mice, Rats Gavage, Intravenous Completed Chad Blystone
Tenofovir Disoproxil Fumarate (TDF) 202138-50-9 Mice Gavage Ongoing Barry McIntyre
Triclocarban 101-20-2 Mice, Rats Dermal, Gavage Completed Vicki Sutherland
Triclosan 3380-34-5 Mice Topical Application Ongoing Vicki Sutherland
Triclosan 3380-34-5 Mice Topical Application Ongoing Jia-Long Fang
Tris(4-chlorophenyl)methane 27575-78-6 Mice, Rats Gavage, Intravenous Completed Natasha Catlin
Tris(4-chlorophenyl)methanol 3010-80-8 Mice, Rats Gavage, Intravenous Completed Natasha Catlin
Tris(Chloropropyl)phosphate 13674-84-5 Mice, Rats Gavage, Intravenous Ongoing Kristen Ryan
Vinpocetine 42971-09-5 Rats Gavage Ongoing Natasha Catlin

*CASRN = Chemical Abstracts Service Registry Number