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Annual Report for Fiscal Year 2017

Annual Report for Fiscal Year 2017
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https://ntp.niehs.nih.gov/go/838055

Toxicology and Carcinogenicity Studies

NTP performs toxicity studies to provide dose-setting information for chronic studies and to address specific deficiencies in the toxicology database for the chemical. Toxicology and carcinogenicity studies fall into two categories: prechronic toxicity studies and chronic two-year toxicology and carcinogenicity studies. Studies are generally conducted in rats and mice.

Each study type is performed according to the Specifications for the Conduct of Studies to Evaluate the Reproductive and Developmental Toxicity of Chemical, Biological and Physical Agents in Laboratory Animals for the National Toxicology Program (NTP) (May 2011). Prechronic and chronic toxicity studies and carcinogenicity studies, that were initiated, ongoing, or completed during FY 2017 are listed below.

Prechronic Toxicology and Carcinogenicity Studies FY 2017

Click the green + for information on the study scientist.

Test Article CASRN* Species Length Route Status Study Scientist
(+)-Usnic Acid 7562-61-0 Mice, Rats 2 weeks Dosed-Feed Ongoing Julian Leakey
(+)-Usnic Acid 7562-61-0 Mice, Rats 90 days Dosed-Feed Ongoing Julian Leakey
1,2,4-trimethylbenzene 95-63-6 Mice, Rats 13 weeks Inhalation Initiated Dan Morgan
1,2-Bis(2,4,6-tribromophenoxy)ethane 37853-59-1 Rats 5 days Gavage Initiated June Dunnick
1,2-bis(pentabromophenyl)ethane 84852-53-9 Rats 5 days Gavage Initiated June Dunnick
1,3,5,7,9,11-Hexabromocyclododecane 25637-99-4 Rats 5 days Gavage Initiated June Dunnick
1020 Long Multiwalled Carbon Nanotube  N/A Mice, Rats 2 years Inhalation Ongoing Dan Morgan
1020 Long Multiwalled Carbon Nanotube  N/A Mice, Rats 30 days Inhalation Ongoing Dan Morgan
2,2',4,4'-Tetrabromodiphenyl Ether 5436-43-1 Rats 5 days Gavage Initiated June Dunnick
2,2'-Dimorpholinodiethyl Ether 6425-39-4 Mice 28 days Gavage Ongoing Troy Hubbard
2-Ethylhexyl Diphenyl Phosphate 1241-94-7 Rats 5 days Gavage Ongoing Scott Auerbach
2-ethylhexyl-2,3,4,5-tetrabromobenzoate 183658-27-7 Rats 5 days Gavage Initiated June Dunnick
3,3',4,4'-Tetrachloroazobenzene 14047-09-7 Rats 5 days Gavage Initiated Mamta Behl
Acrylamide 79-06-1 Rats 5 days Gavage Initiated Frederick Beland
Aging Cohort Study: 12951/SvlmJ mouse N/A Mice 2 years N/A Ongoing June Dunnick
Aging Cohort Study: A/J mouse N/A Mice 2 years N/A Ongoing June Dunnick
Aging Cohort Study: B6C3F1J mouse N/A Mice 2 years N/A Ongoing June Dunnick
Aging Cohort Study: C3H/HeJ mouse N/A Mice 2 years N/A Ongoing June Dunnick
Aging Cohort Study: C57/BL/6J mouse N/A Mice 2 years N/A Ongoing June Dunnick
Aging Cohort Study: CAST/EiJ mouse N/A Mice 2 years N/A Ongoing June Dunnick
Aging Cohort Study: NOD. B10Sn-H2(b)/J N/A Mice 2 years N/A Ongoing June Dunnick
Aging Cohort Study: NZO/HiLtJ mouse N/A Mice 2 years N/A Ongoing June Dunnick
Aging Cohort Study: PWK/PhJ mouse N/A Mice 2 years N/A Ongoing June Dunnick
Aging Cohort Study: WSB/EIJ mouse N/A Mice 2 years N/A Ongoing June Dunnick
Aloin 1415-73-2 Rats 13 weeks Dosed-Water Ongoing Mary Boudreau
alpha/beta Thujone mixture 76231-76-0 Rats 5 days Gavage Initiated William Gwinn
alpha-Pinene 80-56-8 Mice, Rats 2 years Inhalation Ongoing Cynthia Rider
Antimony Trioxide 1309-64-4 Mice, Rats 2 weeks Inhalation Ongoing Matt Stout
Antimony Trioxide 1309-64-4 Mice, Rats 2 years Inhalation Ongoing Matt Stout
AZT/Drug Combinations Transplacental/Neonatal Study  N/A Mice 2 years Gavage Ongoing Frederick Beland
Bis(2-chloroethoxy)methane 111-91-1 Mice 10 days, 3 days Gavage Completed June Dunnick
Bis(2-ethylhexyl) tetrabromophthalate 26040-51-7 Rats 5 days Gavage Initiated June Dunnick
Bisphenol AF 1478-61-1 Rats 5 days Gavage Initiated Vicki Sutherland
Bisphenol S 80-09-1 Mice 14 days Dosed-Feed Initiated Vicki Sutherland
Black Cohosh 84776-26-1 Mice 90 days Gavage Ongoing Michelle Cora
Black Cohosh 84776-26-1 Mice, Rats 2 years Gavage Ongoing Chad Blystone
Brominated Vegetable Oil 8016-94-2 Rats 90 days -- Initiated Gamboa da Costa
Cell Phone Radiation: CDMA N/A Mice, Rats 2 years Whole Body Exposure Ongoing Michael Wyde
Cell Phone Radiation: GSM N/A Mice, Rats 2 years Whole Body Exposure Ongoing Michael Wyde
Coumarin 91-64-5 Rats 5 days Gavage Initiated June Dunnick
Crumbrubber various N/A Mice 14 days  N/A Initiated Georgia Roberts
Cumene 98-82-8 Mice, Rats 14 days Inhalation Ongoing Georgia Roberts
Decabromodiphenyl Ether 1163-19-5 Rats 5 days Gavage Initiated June Dunnick
Di(2-ethylhexyl) Phthalate 117-81-7 Rats 2 years Dosed-Feed Ongoing Troy Hubbard
Di(2-ethylhexyl) Phthalate 117-81-7 Rats 5 days Gavage Initiated Troy Hubbard
Di(2-ethylhexyl) Phthalate 117-81-7 Rats Perinatal + 2 years Dosed-Feed Ongoing Troy Hubbard
Dibutyl Phthalate 84-74-2 Mice, Rats 2 years Dosed-Feed Ongoing Chad Blystone
Dimethylamine Borane 74-94-2 Mice, Rats 2 weeks Dermal Ongoing Dori Germolec
Ephedrine + caffeine combination N/A Mice 10 days, 3 days Gavage Completed June Dunnick
Ethinyl estradiol 57-63-6 Rats 2 weeks Subcutaneous Injection Ongoing Todd Auman
Ethinyl estradiol 57-63-6 Rats 5 days Gavage Initiated Todd Auman
Fenofibrate 49562-28-9 Rats 5 days Gavage Initiated Barry McIntyre
Formaldehyde 50-00-0 Mice 2 weeks Inhalation Ongoing Dan Morgan
Formaldehyde 50-00-0 Mice 8 weeks Inhalation Ongoing Dan Morgan
Furan 110-00-9 Rats 5 days Gavage Initiated Frederick Beland
Ginkgo biloba extract 90045-36-6 Rats 5 days Gavage Ongoing Cynthia Rider
Goldenseal extract 84603-60-1 Rats 5 days Gavage Ongoing Cynthia Rider
Green Tea Extract N/A Rats 5 days Gavage Ongoing Cynthia Rider
Hexachlorobenzene 118-74-1 Rats 5 days Gavage Initiated Michael DeVito
Hexachlorocyclopentadienyl-dibromocyclooctane 51936-55-1 Rats 5 days Gavage Initiated June Dunnick
Indole-3-carbinol 700-06-1 Mice, Rats 2 years Gavage Completed Michael Wyde
Insertional Mutagenesis - Definitive Vector Study N/A Mice 14 months Intravenous Ongoing Dori Germolec
Ionic Liquid: 1-Butyl-1-methylpyrrolidinium Chloride 479500-35-1 Mice, Rats 90 days Dosed-Water Ongoing Kristen Ryan
Ionic Liquid: 1-Butyl-3-methylimidazolium Chloride 79917-90-1 Mice, Rats 90 days Dosed-Water Completed Kristen Ryan
Ionic Liquid: 1-Ethyl-3-methylimidazolium Chloride 65039-09-0 Mice, Rats 90 days Dosed-Water Ongoing Kristen Ryan
Ionic Liquid: N-Butylpyridinium Chloride 1124-64-7 Mice, Rats 90 days Dosed-Water Ongoing Kristen Ryan
Isodecyl Diphenyl Phosphate 29761-21-5 Rats 5 days Gavage Ongoing Scott Auerbach
Isopropylated Phenol Phosphate 68937-41-7 Mice 2 weeks Dosed-Feed Ongoing Mamta Behl
Isopropylated Phenol Phosphate 68937-41-7 Rats 5 days Gavage Ongoing Scott Auerbach
Melamine + Cyanuric Acid combination N/A Rats 90 days Gavage Ongoing Gamboa da Costa
Melamine + Cyanuric Acid combination N/A Rats 90 days + recovery Gavage Ongoing Gamboa da Costa
Metal Working Fluids: TRIM® VX N/A Mice, Rats 13 weeks Inhalation Completed Kristen Ryan
Metal Working Fluids: TRIM® VX N/A Mice, Rats 2 years Inhalation Completed Kristen Ryan
Methyleugenol 93-15-2 Rats 5 days Gavage Initiated Michael DeVito
Microbiome N/A -- -- N/A Ongoing Carl Cerniglia
Milk thistle extract 84604-20-6 Rats 5 days Gavage Initiated June Dunnick
Nanoscale Silver 7440-22-4 Rats 13 weeks Gavage Completed Mary Boudreau
N-Butylbenzenesulfonamide 3622-84-2 Mice 14 days Dosed-Feed Ongoing Cynthia Rider
ortho-Phthalaldehyde 643-79-8 Mice, Rats 90 days Inhalation Ongoing Michael Wyde
Pentabromodiphenyl Ether Mixture [DE-71 (Technical Grade)] 32534-81-9 Rats 5 days Gavage Initiated June Dunnick
Perfluorohexane sulfonate potassium salt (PFHSKslt) 3871-99-6 Rats 28 days Gavage Completed Chad Blystone
Perfluorohexanoic acid (PFHXA) 307-24-4 Rats 28 days Gavage Completed Chad Blystone
Perfluorooctanoic Acid 335-67-1 Rats 2 years Dosed-Feed Ongoing Chad Blystone
Perfluorooctanoic Acid 335-67-1 Rats 28 days Gavage Completed Chad Blystone
Perfluorooctanoic Acid 335-67-1 Rats 5 days Gavage Initiated Chad Blystone
Phenolic Benzotriazoles (2-(2H-benzotriazol-2-yl)-4,6-bis(1-methyl-1-phenylethyl)phenol) 70321-86-7 Rats 14 days Gavage Ongoing Chad Blystone
Phenolic Benzotriazoles (2-(2H-benzotriazol-2-yl)-4,6-bis(1,1-dimethylpropyl)phenol) 25973-55-1 Rats 14 days Gavage Ongoing Chad Blystone
Phenolic Benzotriazoles (2-(2H-Benzotriazol-2-yl)-4-tert-butylphenol) 3147-76-0 Rats 14 days Gavage Ongoing Chad Blystone
Phenolic Benzotriazoles (2-(2H-Benzotriazol-2-yl)phenol) 10096-91-0 Rats 14 days Gavage Ongoing Chad Blystone
Phenolic Benzotriazoles (2-(5-Chloro-2H-benzotriazol-2-yl)-4,6-bis(1,1-dimethylethyl)phenol) 3864-99-1 Rats 14 days Gavage Ongoing Chad Blystone
Phenolic Benzotriazoles (3-(2H-Benzotriazol-2-yl)-5-(1,1-dimethylethyl)-4-hydroxybenzenepropanoic acid, octyl ester) 84268-23-5 Rats 14 days Gavage Ongoing Chad Blystone
Phenolic Benzotriazoles (Bumetrizole) 3896-11-5 Rats 14 days Gavage Ongoing Chad Blystone
Phenolic Benzotriazoles (Drometrizole) 2440-22-4 Rats 14 days Gavage Ongoing Chad Blystone
Phenolic Benzotriazoles (Octrizole) 3147-75-9 Rats 14 days Gavage Ongoing Chad Blystone
p-Toluidine 106-49-0 Rats 5 days Gavage Ongoing June Dunnick
Pulegone 89-82-7 Rats 5 days Gavage Initiated Scott Auerbach
Resveratrol 501-36-0 Mice, Rats 13 weeks Gavage Ongoing Anika Dzierlenga
Resveratrol 501-36-0 Mice, Rats 2 weeks Gavage Ongoing Anika Dzierlenga
Resveratrol 501-36-0 Mice, Rats 2 years Gavage Ongoing Anika Dzierlenga
Sodium Tungstate Dihydrate 10213-10-2 Mice, Rats 2 years Dosed-Water Ongoing Mamta Behl
Sulfolane 126-33-0 Mice, Rats 2 years Dosed-Water Ongoing Chad Blystone
tert-Butylphenyl Diphenyl Phosphate 56803-37-3 Rats 5 days Gavage Ongoing Scott Auerbach
Tetrabromobisphenol A 79-94-7 Rats 13 weeks Gavage Ongoing June Dunnick
Tetrabromobisphenol A 79-94-7 Rats 5 days Gavage Initiated June Dunnick
Triclosan 3380-34-5 Mice 2 years Dermal Ongoing Jia-Long Fang
Triclosan 3380-34-5 Rats 5 days Gavage Initiated Vicki Sutherland
Tricresyl Phosphate 1330-78-5 Rats 5 days Gavage Ongoing Scott Auerbach
Trimethylsilyldiazomethane (TMSD) 18107-18-1 Mice, Rats 10 days Inhalation Ongoing William Gwinn
Triphenyl Phosphate 115-86-6 Mice 2 weeks Dosed-Feed Ongoing Mamta Behl
Triphenyl Phosphate 115-86-6 Rats 5 days Gavage Ongoing Scott Auerbach
Tris(Chloropropyl)phosphate 13674-84-5 Mice, Rats 2 years Dosed-Feed Ongoing Kristen Ryan
Tris(Chloropropyl)phosphate 13674-84-5 Mice, Rats 90 days Dosed-Feed Ongoing Kristen Ryan
Tris(Chloropropyl)phosphate 13674-84-5 Rats 5 days Gavage Initiated Kristen Ryan
Usnea Lichen N/A Mice, Rats 2 weeks Dosed-Feed Ongoing Julian Leakey
Valerian (Valeriana officinalis L.) root extract 8057-49-6 Mice 90 days Gavage Ongoing Troy Hubbard
Water disinfection byproducts (Bromodichloroacetic Acid) 71133-14-7 Rats 5 days Gavage Initiated Michael DeVito
*CASRN = Chemical Abstracts Service Registry Number
**GD: gestational day
***PND: postnatal day