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Annual Report for Fiscal Year 2017

Annual Report for Fiscal Year 2017
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https://ntp.niehs.nih.gov/go/838058

Organ System Toxicity Studies

NTP studies toxicity of environmental substances on development, reproduction, and on the nervous and immune systems. Organ systems toxicity studies Conducted during FY 2017 are listed below.

 
Neurotoxicity, Developmental Toxicity, and Reproductive Toxicity Studies During FY 2017
 
Click the green + for information on the study scientist.

Test Article CASRN* Species Testing Battery Length Route Status Study Scientist
2-((1-(4-Phenoxyphenoxy)propan-2-yl)oxy)pyridine 95737-68-1 Rabbit Conventional Teratology 3 weeks Gavage Scheduled Vicki Sutherland
2-((1-(4-Phenoxyphenoxy)propan-2-yl)oxy)pyridine 95737-68-1 Rabbit Conventional Teratology GD 7-28 Gavage Initiated Vicki Sutherland
2-((1-(4-Phenoxyphenoxy)propan-2-yl)oxy)pyridine 95737-68-1 Rabbit Teratology Pilot Studies -- Gavage Scheduled Vicki Sutherland
2-((1-(4-Phenoxyphenoxy)propan-2-yl)oxy)pyridine 95737-68-1 Rats Conventional Teratology GD 6-21 Gavage Initiated Vicki Sutherland
2-((1-(4-Phenoxyphenoxy)propan-2-yl)oxy)pyridine 95737-68-1 Rats Immunotoxicity 28 days Gavage Initiated Vicki Sutherland
2-Hydroxy-4-methoxybenzophenone 131-57-7 Rats Developmental Toxicity 35 days Dosed-Feed Completed Deborah Hansen
2-Hydroxy-4-methoxybenzophenone 131-57-7 Rats Developmental Toxicity GD 6 to PND 21 Dosed-Feed Ongoing Deborah Hansen
2-Hydroxy-4-methoxybenzophenone 131-57-7 Rats Developmental Toxicity GD 6 to GD 15 Dosed-Feed Ongoing Deborah Hansen
Acenaphthenequinone 82-86-0 Mice Immunotoxicity 28 days Gavage Initiated Cynthia Rider
Arsenic 7440-38-2 Rats Developmental Toxicity Pregnant dams through PND21 Gavage & Dosed-Water Initiated Sherry Ferguson
Benz(j)aceanthrylene 202-33-5 Mice Immunotoxicity 28 days Gavage Scheduled Cynthia Rider
Benzo(a)pyrene 50-32-8 Mice Immunotoxicity 28 days Gavage Ongoing Cynthia Rider
Benzo(b)fluoranthene 205-99-2 Mice Immunotoxicity 28 days Gavage Scheduled Dori Germolec
Benzo(c)fluorene 205-12-9 Mice Immunotoxicity 28 days Gavage Scheduled Dori Germolec
Benzo(k)fluoranthene 207-08-9 Mice Immunotoxicity 28 days Gavage Scheduled Dori Germolec
Bisphenol AF 1478-61-1 Rats Immunotoxicity GD 6 - PND 96 Dosed-Feed Ongoing Vicki Sutherland
Chrysene 218-01-9 Mice Immunotoxicity 28 days Gavage Initiated Cynthia Rider
Dibenz(a,h)anthracene 53-70-3 Mice Immunotoxicity 28 days Gavage Initiated Cynthia Rider
Dibenz(a,h)anthracene 53-70-3 Mice Immunotoxicity 8 GD - PND 42 Subcutaneous Injection Ongoing Cynthia Rider
Dibenzo(a,l)pyrene 191-30-0 Mice Immunotoxicity 28 days Gavage Initiated Cynthia Rider
Dibenzothiophene 132-65-0 Mice Immunotoxicity 28 days Gavage Initiated Cynthia Rider
Efavirenz (EFV) 154598-52-4 Mice Teratology Pilot Studies GD 5 - PND 21 Gavage Ongoing Anika Dzierlenga
Indeno(1,2,3-cd)pyrene 193-39-5 Mice Immunotoxicity 28 days Gavage Scheduled Cynthia Rider
N-Butylbenzenesulfonamide 3622-84-2 Mice Immunotoxicity 28 days Dosed-Feed Initiated Cynthia Rider
N-Butylbenzenesulfonamide 3622-84-2 Rats Immunotoxicity GD 6 - PND 42 Dosed-Feed Initiated Cynthia Rider
Phenanthrene 85-01-8 Mice Immunotoxicity 28 days Gavage Ongoing Cynthia Rider
Pyrene 129-00-0 Mice Immunotoxicity 28 days Gavage Ongoing Cynthia Rider
Sodium Metavanadate 13718-26-8 Mice Immunotoxicity 28 days Dosed-Water Ongoing Georgia Roberts
Sulfolane 126-33-0 Mice Immunotoxicity 13 weeks Gavage Ongoing Chad Blystone
Sulfolane 126-33-0 Rats Immunotoxicity 13 weeks Gavage Ongoing Chad Blystone
Tenofovir Disoproxil Fumarate (TDF) 202138-50-9 Mice Teratology Pilot Studies GD 5 - PND 21 Gavage Ongoing Anika Dzierlenga
Tricombination FTC:TDF:EFV (1:1.5:3) N/A Mice Maternal Transfer GD 5-15 Gavage Completed Barry McIntyre
Tricombination FTC:TDF:EFV (1:1.5:3) N/A Mice Teratology Pilot Studies GD 5 - GD 18 Gavage Completed Barry McIntyre
Tricombination FTC:TDF:EFV (1:1.5:3) N/A Mice Teratology Pilot Studies Gavage Scheduled Anika Dzierlenga
Tris(Chloropropyl)phosphate 13674-84-5 Rats Immunotoxicity GD 6 - PND 127 Dosed-Feed Initiated Kristen Ryan

*CASRN = Chemical Abstracts Service Registry Number
**GD = gestational day
***PND = postnatal day