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Annual Report for Fiscal Year 2018

Annual Report for Fiscal Year 2018
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https://ntp.niehs.nih.gov/go/860784

Report Activities

Activities in FY 2018 primarily focused on carrying out cancer hazard evaluations and preparing monographs for several substances under consideration for possible listing in the RoC.

  • Antimony trioxide. On January 24, 2017, the draft monograph was peer reviewed by a panel of experts. The panel agreed with NTP’s preliminary recommendations to list antimony trioxide in the RoC as reasonably anticipated to be a human carcinogen based on sufficient evidence from studies in experimental animals and supporting mechanistic data.
  • Helicobacter pylori: Chronic infection. Following its release for public comment, the draft monograph on H. pylori was reviewed by letter by three substance-specific experts. The reviewers agreed with NTP’s preliminary recommendations to list H. pylori in the RoC as known to be a human carcinogen based upon sufficient evidence from studies in humans.
  • Shift work at night, light at night, and circadian disruption. On October 5, 2018, NTP convened an external panel to peer review the draft monograph on shift work and light at night. The panel agreed with NTP’s preliminary recommendation to list persistent night shift work that causes circadian disruption as known to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in humans. The panel also accepted NTP’s preliminary recommendation that certain lighting conditions that cause circadian disruption should be listed as reasonably anticipated to be a human carcinogen. The panel recommended that the supporting evidence should refer to "certain lighting conditions" and not "light at night."

For a list of ongoing evaluations, see Report Substances Selected for Evaluation. Preparations are ongoing for the 15th RoC. In addition, ORoC is conducting scoping activities to identify substances for review for future editions of the report.

Additional Links for the Report on Carcinogens:
Report on Carcinogens
About the Report on Carcinogens
Report Substances Selected for Evaluation