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Annual Report for Fiscal Year 2018

Annual Report for Fiscal Year 2018

Report Substances Selected for Evaluation

 NTP Project Leader
Primary Uses/Exposures Status
Antimony trioxide
Amy Wang
This compound is used mainly as a synergist for halogenated flame retardants in plastics, rubber, and textiles, which are used in a diversity of plastics and other products.

It also can be used as a catalyst in polyethylene terephthalate production, as an additive in glass manufacturing and in pigments, or as an additive in paints and ceramics.
Peer-review meeting January 2018

Revised monograph released September 2018
Goldenseal root powder (Hydrastis canadensis)

ORoC staff
This herbal remedy (botanical product) is used to treat gastrointestinal disturbances; urinary disorders; hemorrhage; skin, mouth, and eye infections; and inflammation. Deferred
Haloacetic acids found as water disinfection byproducts
Gloria Jahnke 
This includes 13 individual haloacetic acids or a potential class or subclass of these haloacetic acids.

People are exposed to these haloacetic acids by ingestion of chlorinated drinking water and by inhalation and dermal contact during bathing or showering or when using swimming pools and spas that use chlorine for disinfection.
Final monograph published March 2018
Helicobacter pylori (H. pylori): Chronic infection
Ruth Lunn 
A gram-negative, multiflagellated bacterium, it colonizes the stomach and causes peptic ulcer. Bacterium is spread by person-to-person contact, especially among family members.

Routes of exposure include oral-oral, fecal-oral, and iatrogenic; exposure from contaminated water is also possible. Risk factors for infection include age, race, socioeconomic status such as crowded living conditions, and poor sanitation/hygiene.
Draft monograph released
May 2018

Revised monograph released
September 2018
Shift work at night, light at night, and circadian disruption
Ruth Lunn
Unnatural (e.g., ill-timed) electrical light, especially light at night, might disrupt sleep and biological processes controlled by endogenous circadian clocks. People, who by virtue of the nature of their work, lifestyle choices, or residence, are subjected to exposure to unnatural light.

Shift workers who work at night can experience an extreme type of exposure to light at night and changes in other activities, such as changes in daily activities, eating, sleeping, lifestyle factors, and social behavior.
Draft monograph released
August 2018

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