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Annual Report for Fiscal Year 2018

Annual Report for Fiscal Year 2018
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https://ntp.niehs.nih.gov/go/860671

ICCVAM Publishes 2016–2017 Biennial Report

ICCVAM published its 2016–2017 ICCVAM Biennial Report summarizing activities of member agencies in August 2018. ICCVAM is composed of representatives from 16 regulatory and research agencies, including NIEHS, that require, use, generate, or disseminate toxicological and safety testing information.

The report highlights member agency activities in 2016 and 2017 that supported toxicology innovation as well as regulatory agency initiatives to promote the 3Rs (replace, reduce, or refine animal use) and to provide information about the use of in vitro methods.
Compiled by NICEATM, the biennial report summarizes U.S. government activities to reduce and replace animal use for chemical safety testing. Key ICCVAM and NICEATM accomplishments summarized in the report include:
  • Publication of the "Strategic Roadmap for Establishing New Approaches to Evaluate the Safety of Chemicals and Medical Products in the United States"
  • Publication of guidance documents by EPA describing approaches to reduce animal use in the testing required for pesticide registration
  • Publication of notices by the U.S. Department of Agriculture describing approaches to reduce animal use for vaccine testing
  • Publication of the "Predictive Toxicology Roadmap" by FDA
  • Development of a non-animal defined approach by NICEATM and EPA that can identify substances that might interact with the androgen receptor
  • Development of a non-animal defined approach by NICEATM and ICCVAM to predict skin sensitization risk
  • Development of a proposed method in collaboration with international partners to evaluate non-animal approaches to identify skin sensitizers
  • Launch of the NICEATM Integrated Chemical Environment (ICE), an online e-resource that provides high-quality curated data and computational workflows for chemical safety assessment
Report cover with human head and illustration of computational toxicology