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Annual Report for Fiscal Year 2018

Annual Report for Fiscal Year 2018


The Scientific Advisory Committee on Alternative Toxicological Methods (SACATM) is a federally chartered advisory committee established on January 9, 2002, in response to the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) Authorization Act of 2000 (42 U.S.C. 285l-3[d]). SACATM advises ICCVAM, the NTP Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM), and the director of NIEHS and NTP regarding statutorily mandated duties of ICCVAM and activities of NICEATM. SACATM provides advice on priorities and activities related to the development, validation, scientific review, regulatory acceptance, implementation, and national and international harmonization of new, revised, and alternative toxicological test methods. The SACATM charter and current roster are available on the NTP website, and the roster for FY 2018 is listed below. SACATM typically meets once a year and members serve rotating terms of up to 4 years. Elizabeth Maull, Ph.D., served as the FY 2018 designated federal officer and manager of SACATM.

SACATM met on September 5–6, 2018, at the NIEHS Rodbell Auditorium in Research Triangle Park, North Carolina. In January 2018, ICCVAM published the Strategic Roadmap for Establishing New Approaches to Evaluate the Safety of Chemicals and Medical Products in the United States. The SACATM meeting focused on implementation efforts for the three strategic goals required for its progress:

  • Connect new test method developers with end users.
  • Promote flexible approaches for establishing confidence in new methods.
  • Ensure that new methods will be used by federal agencies and regulated industries once validated.

Members of SACATM and ICCVAM and staff from NIEHS and NTP at the September 2018 SACATM meeting

SACATM Membership Roster FY 2018

Name and Title Affiliation Term End Date
Michael B. Bolger, Ph.D.
Chief Scientist
Simulations Plus, Inc.
Lancaster, California
Kelly P. Coleman, Ph.D., D.A.B.T., R.A.C.
Distinguished Scientist and Technical Fellow
Medtronic PLC
Minneapolis, Minnesota
Hisham Hamadeh, Ph.D., D.A.B.T., M.B.A. Director, Comparative Biology and Safety Sciences Amgen, Inc.
Thousand Oaks, California
William P. Janzen
Executive Director of Lead Discovery
Epizyme, Inc.
Cambridge, Massachusetts
Lawrence Milchak, Ph.D., D.A.B.T.
Senior Manager, Toxicology and Strategic Services
St. Paul, Minnesota
Pamela J. Spencer, Ph.D., D.A.B.T.
Committee Chair
Director of Regulatory and Product Stewardship
ANGUS Chemical Company
Buffalo Grove, Illinois
ClarLynda Williams-Devane, Ph.D.
Director, Bioinformatics, Genomics, and Computational Chemistry
Biotechnology Biomedical Research Institute
North Carolina Central University
Durham, North Carolina
Wei Xu, Ph.D.
Associate Professor, Department of Oncology
McArdle Laboratory for Cancer Research
University of Wisconsin at Madison
Madison, Wisconsin
Hao Zhu, Ph.D.
Assistant Professor, Department of Chemistry
Rutgers University
Camden, New Jersey