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Annual Report for Fiscal Year 2018

Annual Report for Fiscal Year 2018
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https://ntp.niehs.nih.gov/go/860808

Scientific Panels

NTP convenes ad hoc scientific panels, referred to as special emphasis panels, to provide independent scientific peer review and advice on targeted issues, such as agents of public health concern, new and revised toxicological test methods, and others. All panel reviews provide the opportunity for public comment. These panels help ensure that NTP receives transparent, unbiased, and scientifically rigorous input for its use in making credible decisions about human health hazards, setting research and testing priorities, and evaluating test methods for toxicity screening.

NTP Technical Reports Peer Reviewed in FY 2018

NTP technical reports are published results of long-term studies, generally 2-year rodent toxicology and carcinogenesis studies. For each technical report, the panel is charged with reviewing the scientific and technical elements and presentation of the study and determining whether the study’s experimental design and conduct support NTP conclusions regarding the carcinogenic activity of the substance tested.

The draft technical reports, listed below, underwent peer review in FY 2018. Additional information about past technical reports’ peer-review meetings can be found on the NTP Technical Reports Peer-Review Panels web page.

Topic Technical Report Number Use Peer-Review Information
Studies in Rats Exposed to Whole-body Radio Frequency Radiation at a Frequency (900 MHz) Used by Cell Phones TR-595 Utilized in cell phones to transmit between the devices and the network. Actions
Peer-Review Report
Studies in Mice Exposed to Whole-body Radio Frequency Radiation at a Frequency (1,900 MHz) Used by Cell Phones TR-596 Utilized in cell phones to transmit between the devices and the network. Actions
Peer-Review Report

NTP Research Reports Peer Reviewed in FY 2018

Research report peer-review panels are technical, scientific advisory bodies established on an as-needed basis to review drafts reports.

The draft research reports, listed below, underwent peer review in FY 2018. Additional information about past research reports’ peer-review meetings can be found on the NTP Research Reports Peer-Review Panels web page.

Topic Research Report Number Aim Peer-Review Information
National Toxicology Program Approach to Genomic Dose-Response Modeling
RR-05 With expert input, outline NTP’s approach for in vivo and in vitro genomic dose-response studies. Actions
Peer-Review Report
The CLARITY-BPA Core Study: A Perinatal and Chronic Extended-Dose-Range Study of Bisphenol A in Rats RR-09 Characterize the toxicological potential of bisphenol A (BPA) following perinatal-only or a chronic exposure in rats exposed to BPA. Peer-Review Report

NTP Report on Carcinogens Monographs Peer-Reviewed in FY 2018

The Report on Carcinogens monographs are prepared for each candidate substance selected for review and consist of a cancer evaluation component and a substance profile. For each monograph, the panel is charged with commenting on whether the draft cancer evaluation component is technically correct and clearly stated, whether NTP objectively presents and assesses the scientific evidence, and whether the scientific evidence is adequate for applying the listing criteria. For the draft substance profile, the panel is charged with commenting on whether the scientific justification presented supports the preliminary NTP policy decision on the Report on Carcinogens listing status.

The draft Report on Carcinogens monographs, listed below, underwent peer review in FY 2018. Additional information about past Report on Carcinogens monographs’ peer-review meetings can be found on the NTP Report on Carcinogens Monographs Peer-Review Panels web page.

Chemical/Topic CASRN* Use/Aim Peer-Review Information
Antimony Trioxide
1309-64-4 Used as a flame retardant in canvas, textiles, paper, and plastics; also used in batteries, enamels, paint pigment, ceramics, and fiberglass. Actions
Peer-Review Report
Night Shift Work and Light at Night

Evaluate potential carcinogenic hazard from working night shifts and being exposed to ambient lighting conditions at night. Actions
Peer-Review Report
*CASRN = Chemical Abstracts Service Registry Number