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Annual Report for Fiscal Year 2018

Annual Report for Fiscal Year 2018
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https://ntp.niehs.nih.gov/go/860735

Disposition, Metabolism, and Toxicokinetic Studies

Complete dosimetry of a chemical or physical agent describes its absorption, distribution, metabolism, and excretion in the body of both humans and test animals at differing levels of exposure, of all ages, via several routes of exposure, and under varying genetic backgrounds. Substances evaluated during FY 2018 are listed below.

Disposition, Metabolism, and Toxicokinetics Studies during FY 2018

Test Article CASRN* Species Route Status Study Scientist
2-Ethylhexyl p-methoxycinnamate 5466-77-3 Rats Dosed-feed, gavage, intravenous Ongoing Barry McIntyre
2-((1-(4-Phenoxyphenoxy)propan-2-yl)oxy)pyridine 95737-68-1 Rats, rabbit Gavage Ongoing Barry McIntyre
Bisphenol AF 1478-61-1 Mice, rats Gavage, intravenous Ongoing Veronica Godfrey Robinson
Efavirenz (EFV) 154598-52-4 Mice Gavage Completed Barry McIntyre
Emtricitabine (FTC) 143491-57-0 Mice Gavage Completed Barry McIntyre
Phenolic benzotriazoles (2-(2H-benzotriazol-2-yl)-4,6-bis(1-methyl-1-phenylethyl)phenol) 70321-86-7 Rats Gavage, intravenous Ongoing Chad Blystone
Phenolic benzotriazoles (2-(2H-Benzotriazol-2-yl)-4-tert-butylphenol) 3147-76-0 Rats Gavage, intravenous Ongoing Chad Blystone
Phenolic benzotriazoles (2-(2H-Benzotriazol-2-yl)phenol) 10096-91-0 Rats Gavage, intravenous Ongoing Chad Blystone
Phenolic benzotriazoles (2-(5-Chloro-2H-benzotriazol-2-yl)-4,6-bis(1,1-dimethylethyl)phenol) 3864-99-1 Rats Gavage, intravenous Ongoing Chad Blystone
Phenolic benzotriazoles (3-(2H-Benzotriazol-2-yl)-5-(1,1-dimethylethyl)-4-hydroxybenzenepropanoic acid, octyl ester) 84268-23-5 Rats Gavage, intravenous Ongoing Chad Blystone
Phenolic benzotriazoles (Bumetrizole) 3896-11-5 Rats Gavage, intravenous Ongoing Chad Blystone
Phenolic benzotriazoles (Drometrizole) 2440-22-4 Rats Gavage, intravenous Ongoing Chad Blystone
Polyethylene glycol monomethyl ether N/A Rats Subcutaneous injection Ongoing Nigel Walker
Sulfolane 126-33-0 Mice, rats Gavage, intravenous Ongoing Chad Blystone
Tenofovir disoproxil fumarate (TDF) 202138-50-9 Mice Gavage Completed Barry McIntyre
Tricombination FTC:TDF:EFV (1:1.5:3) N/A Mice Gavage, intravenous Completed Barry McIntyre
Tris(chloropropyl)phosphate 13674-84-5 Mice, rats Gavage, intravenous Completed Kristen Ryan
Vinpocetine 42971-09-5 Rats Gavage Completed Natasha Catlin

*CASRN = Chemical Abstracts Service Registry Number

Related Links:
Genetic Toxicity Studies 
Organ System Toxicity Studies 
Modified One-Generation Reproduction Studies
Toxicology and Carcinogenicity Studies
Toxicogenomic Studies